| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
License and milestone revenue | ||||||||||
- | - | - | - | - | - | - | - | 6,731 | 4,572 | 125,701 |
Cost sharing reimbursements, net | ||||||||||
- | - | - | - | - | - | - | - | - | 9,253 | 18,544 |
Total collaboration revenues | ||||||||||
- | - | - | - | - | - | - | - | 6,731 | 13,825 | 144,245 |
Grant revenue | ||||||||||
- | - | - | - | - | - | - | 147 | 853 | 978 | - |
Total revenues | ||||||||||
- | - | - | - | - | - | - | 147 | 7,584 | 14,803 | 144,245 |
Operating expenses: | ||||||||||
Research and development | ||||||||||
72,324 | 25,389 | 24,390 | 15,933 | 2,427 | 68,205 | 71,860 | 49,412 | 41,464 | 40,252 | 51,054 |
General and administrative | ||||||||||
22,648 | 15,293 | 7,672 | 9,290 | 805 | 15,746 | 15,699 | 11,676 | 11,552 | 11,449 | 12,651 |
Restructuring | ||||||||||
- | - | - | - | - | - | - | - | - | - | 1,236 |
Total operating expenses | ||||||||||
94,972 | 40,682 | 32,062 | 25,223 | 3,232 | 83,951 | 87,559 | 61,088 | 53,016 | 51,701 | 64,941 |
Loss from operations | ||||||||||
-94,972 | -40,682 | -32,062 | -25,223 | -3,232 | -83,951 | -87,559 | -60,941 | -45,432 | -36,898 | 79,304 |
Interest income (expense), net | ||||||||||
- | - | - | - | - | -2,210 | -2,633 | -1,849 | -1,948 | -569 | -216 |
Interest expense | ||||||||||
- | - | - | 1,213 | 3,611 | - | - | - | - | - | - |
Interest income | ||||||||||
11,024 | 7,671 | 558 | 48 | - | - | - | - | - | - | - |
Other income | ||||||||||
- | 200 | 350 | - | - | - | - | - | - | - | - |
Net loss | ||||||||||
-83,900 | -32,811 | -31,154 | -26,388 | -6,844 | -86,161 | -90,192 | -62,790 | -47,380 | -37,467 | 79,088 |
Net loss per common share: | ||||||||||
Basic and diluted net loss per common share (in dollars per share) | ||||||||||
-5.45 | -2.22 | -2.54 | -5.07 | -40.03 | -0.87 | -1.27 | -1.06 | -1.00 | -0.93 | - |
Basic and diluted weighted average number of common shares outstanding | ||||||||||
15,394 | 14,796 | 12,244 | 5,204 | 171 | 98,489 | 70,976 | 59,411 | 47,197 | 40,365 | - |
Basic (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | - | - | - | 2.33 |
Diluted (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | - | - | - | 2.32 |
Basic weighted average number of common shares outstanding (in shares) | ||||||||||
- | - | - | - | - | - | - | - | - | - | 33,887 |
Diluted weighted average number of common shares outstanding (in shares) | ||||||||||
- | - | - | - | - | - | - | - | - | - | 34,118 |