| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||||||||||||||||||||
Cash flows from operating activities | ||||||||||||||||||||||||||||
Net loss | ||||||||||||||||||||||||||||
-44,724 | -30,396 | -44,631 | -31,767 | -45,017 | -44,644 | -34,029 | -43,244 | -49,536 | 105,727 | -47,043 | -40,655 | -37,655 | -34,783 | -33,846 | 40,464 | -30,363 | -28,451 | -15,442 | -21,376 | 45,129 | -19,018 | -3,928 | -12,259 | -3,108 | -3,205 | 6,604 | -294 | -3,365 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||||||||
Depreciation and amortization expense | ||||||||||||||||||||||||||||
2,809 | 2,726 | 2,636 | 2,580 | 2,903 | 3,011 | 2,728 | 1,202 | 1,338 | 1,342 | 1,905 | 2,003 | 1,978 | 1,974 | 2,077 | 1,786 | 1,771 | 1,192 | 489 | 636 | 546 | 505 | 482 | 437 | 398 | 358 | 317 | 265 | 252 |
Stock-based compensation | ||||||||||||||||||||||||||||
4,491 | 5,490 | 5,398 | 4,884 | 3,799 | 4,352 | 4,573 | 4,163 | 3,432 | 3,680 | 4,001 | 3,602 | 3,461 | 3,039 | 3,002 | 3,123 | 3,001 | 2,216 | 2,098 | 1,902 | 1,631 | 995 | 856 | 781 | 612 | 468 | 137 | 112 | 144 |
Fair value adjustment of warrant liability | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 554 | 41 | 30 |
Changes in operating assets and liabilities: | ||||||||||||||||||||||||||||
Accounts receivable | ||||||||||||||||||||||||||||
-938 | 3,241 | 3,891 | -503 | -23,468 | 8,613 | 3,134 | 10,555 | -6,361 | 11,448 | 203 | -102 | -671 | -244 | -75,367 | 75,864 | 1,287 | -1,520 | -1,590 | 2,615 | -1,216 | -2,380 | 2,670 | 899 | -258 | -277 | -1,872 | 1,831 | 275 |
Prepaid expenses | ||||||||||||||||||||||||||||
1,345 | -734 | 2,403 | 1,307 | 1,902 | 2,091 | 1,142 | -155 | 177 | -110 | -747 | -1,010 | 1,535 | 2,172 | -2,471 | 2,079 | -103 | -178 | -1,082 | -551 | -594 | 1,758 | 353 | 163 | 965 | -132 | 1,033 | 13 | -80 |
Other assets | ||||||||||||||||||||||||||||
-695 | -1,043 | -18,470 | 19,012 | 2,079 | -4,713 | 3,782 | 5,551 | -40 | -94 | -103 | -146 | 81 | -875 | 173 | 128 | 298 | 585 | -300 | 0 | 0 | 1,331 | -381 | -1,165 | 1,394 | - | - | - | 0 |
Accounts payable | ||||||||||||||||||||||||||||
-2,286 | 1,700 | 1,685 | -67 | -2,531 | 3,019 | -781 | -8,499 | 7,815 | 594 | -112 | 197 | -2,223 | 2,365 | 222 | 33 | -388 | -1,035 | 688 | 409 | -225 | -2,719 | 411 | -1,156 | 1,964 | 1,371 | -321 | -675 | -944 |
Accrued expenses | ||||||||||||||||||||||||||||
-2,118 | -1,379 | -2,015 | 1,634 | -4,297 | -5,954 | 1,245 | 6,738 | 1,477 | 3,331 | 3,316 | 4,362 | 1,823 | 764 | 3,029 | 2,654 | -1,788 | 2,355 | 815 | 1,304 | -929 | 3,899 | 721 | 574 | -848 | 2,644 | -1 | -320 | 24 |
Lease liabilities | ||||||||||||||||||||||||||||
-869 | -966 | 3,616 | -855 | 1,086 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Lease exit liability | ||||||||||||||||||||||||||||
- | - | - | - | - | - | 0 | 0 | -298 | - | -405 | -392 | -379 | - | -339 | -1,646 | -488 | -460 | -450 | -1,987 | -396 | -372 | -364 | -355 | -348 | -163 | -159 | -155 | -151 |
Deferred revenue | ||||||||||||||||||||||||||||
-2,248 | -13,755 | 3,747 | -5,431 | -5,430 | 19,212 | -2,436 | -1,936 | -1,435 | 9,199 | -800 | -801 | -1,065 | 729 | -1,741 | -1,286 | -1,893 | -555 | -3,856 | -3,863 | -3,949 | -3,949 | -9,927 | 7,770 | 9,423 | -2,707 | -7,197 | -7,110 | 338 |
Deferred rent | ||||||||||||||||||||||||||||
- | - | - | - | - | -233 | -222 | -204 | -312 | -367 | 7,137 | -329 | -326 | -288 | -283 | -283 | -280 | 48 | 5,052 | -426 | -24 | -38 | -45 | -45 | -106 | 16 | 34 | 34 | 18 |
Other liabilities | ||||||||||||||||||||||||||||
515 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||||||||||
-44,142 | -38,044 | -17,388 | -48,838 | -30,000 | -27,228 | -36,980 | -57,731 | -31,295 | 111,845 | -31,354 | -30,755 | -35,331 | -28,329 | 49,786 | -33,226 | -31,910 | -24,155 | -7,634 | -25,465 | 43,593 | -20,164 | -14,331 | -4,150 | 5,886 | -1,184 | 807 | -9,946 | -3,848 |
Cash flows from investing activities | ||||||||||||||||||||||||||||
Cash flows from investing activities | ||||||||||||||||||||||||||||
Purchases of marketable securities | ||||||||||||||||||||||||||||
61,186 | 50,221 | 71,873 | 60,708 | 81,597 | 12,711 | 33,548 | 62,039 | 24,452 | 45,998 | 32,187 | 0 | 56,937 | 78,065 | 67,305 | 119,276 | 83,116 | 142,910 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Proceeds from sale and maturities of marketable securities | ||||||||||||||||||||||||||||
73,003 | 59,094 | 66,281 | 51,175 | 12,780 | 58,500 | 37,758 | 59,732 | 58,358 | 65,395 | 46,501 | 80,433 | 50,072 | 81,161 | 66,122 | 68,198 | 73,413 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Purchases of property and equipment | ||||||||||||||||||||||||||||
1,253 | 1,247 | 780 | 587 | 1,675 | 715 | 4,216 | 5,504 | 14,519 | 10,758 | 9,850 | 7,303 | 1,492 | 1,062 | 1,980 | 5,508 | 2,831 | 2,780 | 2,608 | 2,812 | 997 | 1,658 | 672 | 795 | 447 | 924 | 1,161 | 450 | 425 |
Net cash provided by (used in) investing activities | ||||||||||||||||||||||||||||
10,564 | 7,626 | -6,372 | -10,120 | -70,492 | 45,074 | -6 | -7,811 | 19,387 | 8,639 | 4,464 | 73,130 | -8,357 | 2,034 | -3,163 | -56,586 | -12,534 | -145,690 | -2,608 | -2,812 | -997 | -1,658 | -672 | -795 | -447 | -924 | -1,161 | -450 | -425 |
Cash flows from financing activities | ||||||||||||||||||||||||||||
Cash flows from financing activities | ||||||||||||||||||||||||||||
Proceeds from issuance of common stock, net of offering costs | ||||||||||||||||||||||||||||
0 | 0 | 0 | 0 | 118,657 | 0 | 0 | 103,259 | 0 | - | - | - | - | - | - | - | - | 0 | 140,775 | 0 | 62,692 | -17 | 0 | 0 | 76,733 | - | - | 652 | 56 |
Proceeds from stock option exercises and ESPP purchases | ||||||||||||||||||||||||||||
162 | 297 | 37 | 633 | 348 | 735 | 132 | 496 | 629 | 449 | 28 | 559 | 108 | 531 | 1,011 | 127 | 224 | 279 | 207 | 170 | 255 | 258 | 180 | 238 | 68 | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||||||||||
162 | 297 | 37 | 633 | 119,005 | 475 | 132 | 103,755 | 629 | 359 | 1,147 | 33,734 | 108 | 492 | 1,011 | 127 | 224 | 250 | 140,982 | 170 | 62,947 | 222 | 180 | 238 | 76,801 | 85,020 | 142 | 652 | 56 |
Net change in cash and cash equivalents | ||||||||||||||||||||||||||||
-33,416 | -30,121 | -23,723 | -58,325 | 18,513 | 18,321 | -36,854 | 38,213 | -11,279 | 120,843 | -25,743 | 76,109 | -43,580 | -25,803 | 47,634 | -89,685 | -44,220 | -169,595 | 130,740 | -28,107 | 105,543 | -21,600 | -14,823 | -4,707 | 82,240 | 82,912 | -212 | -9,744 | -4,217 |
Supplemental Cash Flow Information [Abstract] | ||||||||||||||||||||||||||||
Right-of-use assets modified in exchange for operating lease obligations | ||||||||||||||||||||||||||||
0 | 0 | 4,420 | 0 | 1,988 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |