| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||||||||||||||||||||||
Cash flows from operating activities | ||||||||||||||||||||||||||||
Net loss | ||||||||||||||||||||||||||||
-151,518 | -151,811 | -166,059 | -155,457 | -166,934 | -171,453 | -21,082 | -34,096 | -31,507 | -19,626 | -160,136 | -146,939 | -65,820 | -58,528 | -52,196 | -33,792 | -95,632 | -20,140 | -10,707 | 807 | 9,924 | -38,313 | -22,500 | -11,968 | -3 | -261 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||||||||
Depreciation and amortization expense | ||||||||||||||||||||||||||||
10,751 | 10,845 | 11,130 | 11,222 | 9,844 | 8,279 | 6,610 | 5,787 | 6,588 | 7,228 | 7,860 | 8,032 | 7,815 | 7,608 | 6,826 | 5,238 | 4,088 | 2,863 | 2,176 | 2,169 | 1,970 | 1,822 | 1,675 | 1,510 | 1,338 | 1,193 | 0 | 0 | 0 |
Stock-based compensation | ||||||||||||||||||||||||||||
20,263 | 19,571 | 18,433 | 17,608 | 16,887 | 16,520 | 15,848 | 15,276 | 14,715 | 14,744 | 14,103 | 13,104 | 12,625 | 12,165 | 11,342 | 10,438 | 9,217 | 7,847 | 6,626 | 5,384 | 4,263 | 3,244 | 2,717 | 1,998 | 1,329 | 862 | 0 | 0 | 0 |
Fair value adjustment of warrant liability | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 626 | 0 | 0 | 0 |
Changes in operating assets and liabilities: | ||||||||||||||||||||||||||||
Accounts receivable | ||||||||||||||||||||||||||||
5,691 | -16,839 | -11,467 | -12,224 | -1,166 | 15,941 | 18,776 | 15,845 | 5,188 | 10,878 | -814 | -76,384 | -418 | 1,540 | 264 | 74,041 | 792 | -1,711 | -2,571 | 1,689 | -27 | 931 | 3,034 | -1,508 | -575 | -42 | 0 | 0 | 0 |
Prepaid expenses | ||||||||||||||||||||||||||||
4,321 | 4,878 | 7,703 | 6,442 | 4,980 | 3,255 | 1,054 | -835 | -1,690 | -332 | 1,950 | 226 | 3,315 | 1,677 | -673 | 716 | -1,914 | -2,405 | -469 | 966 | 1,680 | 3,239 | 1,349 | 2,029 | 1,879 | 834 | 0 | 0 | 0 |
Other assets | ||||||||||||||||||||||||||||
-1,196 | 1,578 | -2,092 | 20,160 | 6,699 | 4,580 | 9,199 | 5,314 | -383 | -262 | -1,043 | -767 | -493 | -276 | 1,184 | 711 | 583 | 285 | 1,031 | 950 | -215 | 1,179 | 0 | 0 | 0 | - | - | - | 0 |
Accounts payable | ||||||||||||||||||||||||||||
1,032 | 787 | 2,106 | -360 | -8,792 | 1,554 | -871 | -202 | 8,494 | -1,544 | 227 | 561 | 397 | 2,232 | -1,168 | -702 | -326 | -163 | -1,847 | -2,124 | -3,689 | -1,500 | 2,590 | 1,858 | 2,338 | -570 | 0 | 0 | 0 |
Accrued expenses | ||||||||||||||||||||||||||||
-3,878 | -6,057 | -10,632 | -7,372 | -2,268 | 3,506 | 12,791 | 14,862 | 12,486 | 12,832 | 10,265 | 9,978 | 8,270 | 4,659 | 6,250 | 4,036 | 2,686 | 3,545 | 5,089 | 4,995 | 4,265 | 4,346 | 3,091 | 2,369 | 1,474 | 2,347 | 0 | 0 | 0 |
Lease liabilities | ||||||||||||||||||||||||||||
926 | 2,881 | 3,847 | 231 | 1,086 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Lease exit liability | ||||||||||||||||||||||||||||
- | - | - | - | - | - | 0 | 0 | 0 | - | 0 | 0 | -2,713 | - | -2,933 | -3,044 | -3,385 | -3,293 | -3,205 | -3,119 | -1,487 | -1,439 | -1,230 | -1,025 | -825 | -629 | 0 | 0 | 0 |
Deferred revenue | ||||||||||||||||||||||||||||
-17,687 | -20,869 | 12,098 | 5,915 | 9,410 | 13,405 | 3,392 | 5,028 | 6,163 | 6,533 | -1,937 | -2,878 | -3,363 | -4,191 | -5,475 | -7,590 | -10,167 | -12,223 | -15,617 | -21,688 | -10,055 | 3,317 | 4,559 | 7,289 | -7,591 | -16,676 | 0 | 0 | 0 |
Deferred rent | ||||||||||||||||||||||||||||
- | - | - | - | - | -971 | -1,105 | 6,254 | 6,129 | 6,115 | 6,194 | -1,226 | -1,180 | -1,134 | -798 | 4,537 | 4,394 | 4,650 | 4,564 | -533 | -152 | -234 | -180 | -101 | -21 | 103 | 0 | 0 | 0 |
Other liabilities | ||||||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||||||||||
-148,412 | -134,270 | -123,454 | -143,046 | -151,939 | -153,234 | -14,161 | -8,535 | 18,441 | 14,405 | -125,769 | -44,629 | -47,100 | -43,679 | -39,505 | -96,925 | -89,164 | -13,661 | -9,670 | -16,367 | 4,948 | -32,759 | -13,779 | 1,359 | -4,437 | -14,172 | 0 | 0 | 0 |
Cash flows from investing activities | ||||||||||||||||||||||||||||
Cash flows from investing activities | ||||||||||||||||||||||||||||
Purchases of marketable securities | ||||||||||||||||||||||||||||
243,988 | 264,399 | 226,889 | 188,564 | 189,895 | 132,750 | 166,037 | 164,676 | 102,637 | 135,122 | 167,189 | 202,307 | 321,583 | 347,762 | 412,607 | 345,302 | 226,026 | 142,910 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Proceeds from sale and maturities of marketable securities | ||||||||||||||||||||||||||||
249,553 | 189,330 | 188,736 | 160,213 | 168,770 | 214,348 | 221,243 | 229,986 | 250,687 | 242,401 | 258,167 | 277,788 | 265,553 | 288,894 | 207,733 | 141,611 | 73,413 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Purchases of property and equipment | ||||||||||||||||||||||||||||
3,867 | 4,289 | 3,757 | 7,193 | 12,110 | 24,954 | 34,997 | 40,631 | 42,430 | 29,403 | 19,707 | 11,837 | 10,042 | 11,381 | 13,099 | 13,727 | 11,031 | 9,197 | 8,075 | 6,139 | 4,122 | 3,572 | 2,838 | 3,327 | 2,982 | 2,961 | 0 | 0 | 0 |
Net cash provided by (used in) investing activities | ||||||||||||||||||||||||||||
1,698 | -79,358 | -41,910 | -35,544 | -33,235 | 56,644 | 20,209 | 24,679 | 105,620 | 77,876 | 71,271 | 63,644 | -66,072 | -70,249 | -217,973 | -217,418 | -163,644 | -152,107 | -8,075 | -6,139 | -4,122 | -3,572 | -2,838 | -3,327 | -2,982 | -2,961 | 0 | 0 | 0 |
Cash flows from financing activities | ||||||||||||||||||||||||||||
Cash flows from financing activities | ||||||||||||||||||||||||||||
Proceeds from issuance of common stock, net of offering costs | ||||||||||||||||||||||||||||
0 | 118,657 | 118,657 | 118,657 | 221,916 | 103,259 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | 203,467 | 203,450 | 62,675 | 62,675 | 76,716 | 0 | 0 | 0 | - | - | 0 | 0 |
Proceeds from stock option exercises and ESPP purchases | ||||||||||||||||||||||||||||
1,129 | 1,315 | 1,753 | 1,848 | 1,711 | 1,992 | 1,706 | 1,602 | 1,665 | 1,144 | 1,226 | 2,209 | 1,777 | 1,893 | 1,641 | 837 | 880 | 911 | 890 | 863 | 931 | 744 | 0 | 0 | 0 | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||||||||||
1,129 | 119,972 | 120,150 | 120,245 | 223,367 | 104,991 | 104,875 | 105,890 | 35,869 | 35,348 | 35,481 | 35,345 | 1,738 | 1,854 | 1,612 | 141,583 | 141,626 | 204,349 | 204,321 | 63,519 | 63,587 | 77,441 | 162,239 | 162,201 | 162,615 | 85,871 | 0 | 0 | 0 |
Net change in cash and cash equivalents | ||||||||||||||||||||||||||||
-145,585 | -93,656 | -45,214 | -58,345 | 38,193 | 8,401 | 110,923 | 122,034 | 159,930 | 127,629 | -19,017 | 54,360 | -111,434 | -112,074 | -255,866 | -172,760 | -111,182 | 38,581 | 186,576 | 41,013 | 64,413 | 41,110 | 145,622 | 160,233 | 155,195 | 68,738 | 0 | 0 | 0 |
Supplemental Cash Flow Information [Abstract] | ||||||||||||||||||||||||||||
Right-of-use assets modified in exchange for operating lease obligations | ||||||||||||||||||||||||||||
4,420 | 6,408 | 6,408 | 1,988 | 1,988 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |