| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 |
|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||
Net loss | ||||||||
-81,946 | -76,769 | -70,211 | -65,236 | -61,188 | -57,515 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||
Stock-based compensation expense | ||||||||
10,164 | 10,001 | 10,490 | 11,404 | 11,855 | 10,703 | 0 | 0 | 0 |
Depreciation and amortization expense | ||||||||
1,913 | 1,843 | 1,717 | 1,443 | 1,151 | 875 | 0 | 0 | 0 |
Net amortization (accretion) of premiums (discounts) on marketable securities | ||||||||
683 | 1,009 | 0 | 0 | 0 | - | - | - | - |
Changes in operating assets and liabilities: | ||||||||
Prepaid expenses and other current assets | ||||||||
-5,044 | 1,363 | 1,635 | 8,408 | 6,770 | 1,811 | 0 | 0 | 0 |
Accounts payable | ||||||||
1,938 | 145 | -233 | 1,075 | 636 | 2,500 | 0 | 0 | 0 |
Accrued expenses and other current liabilities | ||||||||
4,178 | 5,089 | 1,876 | 2,170 | 1,764 | 2,239 | 0 | 0 | 0 |
Deferred rent | ||||||||
-568 | -4,960 | 0 | 0 | 0 | - | - | - | - |
Net cash used in operating activities | ||||||||
-58,824 | -57,103 | -54,100 | -53,142 | -47,218 | -41,886 | 0 | 0 | 0 |
Cash flows from investing activities: | ||||||||
Purchases of property and equipment | ||||||||
1,940 | 3,060 | 7,258 | 9,203 | 8,762 | 7,672 | 0 | 0 | 0 |
Purchases of marketable securities | ||||||||
130,365 | 144,371 | 0 | 0 | 0 | - | - | - | - |
Maturities of marketable securities | ||||||||
171,963 | 148,963 | 0 | 0 | 0 | - | - | - | - |
Net cash provided by (used in) investing activities | ||||||||
39,658 | 1,532 | -81,139 | -147,422 | -104,273 | -91,703 | 0 | 0 | 0 |
Cash flows from financing activities: | ||||||||
Payments of public offering costs | ||||||||
- | - | - | - | - | 3,094 | 0 | 0 | 0 |
Payments of redeemable convertible preferred stock issuance costs | ||||||||
- | - | - | - | - | 88 | 0 | 0 | 0 |
Proceeds from exercise of common stock options | ||||||||
2,582 | 2,021 | 0 | 0 | 0 | - | - | - | - |
Net cash provided by financing activities | ||||||||
62,858 | 62,297 | 60,907 | 60,081 | 142,885 | 142,147 | 0 | 0 | 0 |
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||||
43,692 | 6,726 | -74,332 | -140,483 | -8,606 | 8,558 | 0 | 0 | 0 |
Supplemental disclosure of non-cash investing and financing activities: | ||||||||
Purchase of property and equipment included in accounts payable and accrued expenses | ||||||||
0 | - | - | 1,579 | 2,591 | 1,538 | 0 | 0 | 0 |
Deferred offering and redeemable convertible preferred share issuance costs included in accounts payable or accrued expenses | ||||||||
0 | - | - | - | 0 | - | - | - | - |
Deferred offering and redeemable convertible preferred share issuance costs included in accounts payable and accrued expenses | ||||||||
0 | - | - | 0 | 0 | - | - | 0 | 0 |