| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 |
|---|---|---|---|---|---|---|---|
Operating activities: | |||||||
Net loss | |||||||
-12,941 | -14,675 | -11,163 | -10,865 | -8,845 | -9,195 | -4,028 | -10,961 |
Adjustments to reconcile net loss to net cash used in operating activities: | |||||||
Non-cash stock-based compensation | |||||||
4,112 | 6,330 | 4,474 | 3,972 | 2,025 | 1,638 | 1,216 | 709 |
Amortization of Kissei upfront payment | |||||||
- | - | - | - | - | - | -3 | -802 |
Depreciation and amortization | |||||||
23 | 25 | 28 | 14 | 26 | 40 | 100 | 69 |
Tax benefit from fluctuations in other comprehensive income | |||||||
- | - | - | -1 | - | -9 | - | - |
Gain on disposal of assets | |||||||
- | - | - | - | - | - | 4 | -0 |
Change in joint venture investment | |||||||
- | 19 | -1 | -32 | -34 | 3 | 13 | - |
Changes in assets and liabilities: | |||||||
Receivables, prepaid expenses and other current and long-term assets | |||||||
514 | 111 | - | - | - | - | - | - |
Prepaid expenses and other assets | |||||||
- | - | -242 | -175 | 284 | -1,186 | 1,353 | -266 |
Receivables | |||||||
- | - | - | - | - | -6,008 | 6,008 | - |
Accounts payable, accrued liabilities and other liabilities | |||||||
194 | -663 | 1,246 | 127 | -109 | 1,152 | - | - |
Deferred tax liability, deferred revenue and other long-term liabilities | |||||||
- | - | -1,754 | - | - | - | - | - |
Accounts payable, accrued expenses and deferred rent | |||||||
- | - | - | - | - | - | -509 | -776 |
Accrued compensation and related expenses | |||||||
- | - | - | - | - | - | -41 | -370 |
Net cash used in operating activities | |||||||
-9,124 | -9,114 | -6,923 | -6,546 | -7,152 | 816 | -10,646 | -11,864 |
Investing activities: | |||||||
Proceeds from dissolution of joint venture | |||||||
- | 636 | - | - | - | - | - | - |
Acquisition of property and equipment | |||||||
11 | 10 | - | 84 | 2 | 3 | 41 | 83 |
Net cash used in investing activities | |||||||
-11 | 626 | - | -84 | -2 | -3 | -36 | -763 |
Financing activities: | |||||||
Investment in China Joint Venture | |||||||
- | - | - | - | - | - | - | 680 |
Proceeds from sales of property and equipment | |||||||
- | - | - | - | - | - | 4 | - |
Proceeds from issuance of common stock, exercise of common stock options and warrants, net of issuance costs | |||||||
10,588 | 42,757 | 10,719 | 8,577 | 17,473 | 4,101 | - | - |
Proceeds from issuance of equity under ESPP | |||||||
- | - | - | - | - | 60 | 13,363 | 1,486 |
Net proceeds from issuance of Treasury Stock under ESPP | |||||||
- | - | - | - | - | - | 6 | 58 |
Proceeds from issuance of equity awards under ESPP | |||||||
27 | 51 | 77 | 87 | 89 | - | - | - |
Net cash provided by financing activities | |||||||
10,615 | 42,808 | 10,797 | 8,665 | 17,563 | 4,162 | 13,370 | 1,545 |
Effect of exchange rate changes on cash and cash equivalents | |||||||
-0 | 0 | - | - | - | - | - | - |
Effect of exchange rate changes on cash and cash equivalents | |||||||
- | - | 0 | 6 | -1 | -6 | 2 | - |
Net change in cash and cash equivalents | |||||||
1,479 | 34,321 | 3,873 | 2,041 | 10,407 | 4,968 | 2,689 | -11,082 |
Supplemental disclosure of cash flow information: | |||||||
Income taxes paid | |||||||
11 | 6 | 9 | 6 | 7 | 5 | 6 | 10 |