| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenue | ||||||||||
23,868 | 75,589 | 138,882 | 109,619 | 89,650 | 52,250 | 35,465 | 63,921 | 283,068 | 116,772 | 20,249 |
Operating expenses: | ||||||||||
Research and development | ||||||||||
144,542 | 124,004 | 149,226 | 119,880 | 126,033 | 106,482 | 103,999 | 80,345 | 64,657 | 51,712 | 60,612 |
General and administrative | ||||||||||
149,822 | 85,105 | 82,207 | 0 | 48,051 | 45,164 | 41,057 | 43,682 | 38,710 | 28,595 | 23,800 |
Restructuring | ||||||||||
110 | 17,807 | 0 | 0 | - | - | - | - | - | - | - |
Other operating expense | ||||||||||
41,205 | 30,000 | 0 | 64,466 | - | - | - | - | - | - | - |
Gain (Loss) on Termination of Lease | ||||||||||
13,720 | 0 | 0 | - | - | - | - | - | - | - | - |
Total operating expenses | ||||||||||
321,959 | 256,916 | 231,433 | 184,346 | 174,084 | 151,646 | 145,056 | 124,027 | 103,367 | 80,307 | 84,412 |
Operating loss | ||||||||||
-298,091 | -181,327 | -92,551 | -74,727 | -84,434 | -99,396 | -109,591 | -60,106 | 179,701 | 36,465 | -64,163 |
Other income (expense): | ||||||||||
Interest income | ||||||||||
9,206 | 6,194 | 4,427 | 2,226 | 808 | 548 | 950 | 1,238 | 746 | 176 | 825 |
Interest expense | ||||||||||
2,018 | 0 | 0 | - | - | - | - | - | 91 | 329 | 570 |
Other income (expense), net | ||||||||||
848 | -928 | 28 | 51,498 | 313 | 248 | 233 | 220 | - | 978 | -104 |
Other income, net | ||||||||||
8,036 | 5,266 | 4,455 | 53,724 | 1,121 | 796 | 1,183 | 1,458 | 655 | 825 | 151 |
Net loss | ||||||||||
-290,055 | -176,061 | -88,096 | -21,003 | -83,313 | -98,600 | -108,408 | -58,648 | 180,356 | 37,290 | -64,012 |
Earnings Per Share [Abstract] | ||||||||||
Basic and diluted net loss per share (in dollars per share) | ||||||||||
-2.92 | -2.26 | -1.20 | -0.31 | -1.32 | -1.91 | -2.13 | -1.16 | - | - | - |
Basic (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | - | 3.62 | 0.84 | -1.60 |
Diluted (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | - | 3.55 | 0.81 | -1.60 |
Weighted average shares outstanding: | ||||||||||
Weighted average shares used in computing basic and diluted net loss per share (in shares) | ||||||||||
99,339 | 77,845 | 73,136 | 68,656 | 63,130 | 51,664 | 50,907 | 50,411 | - | - | - |
Basic (in shares) | ||||||||||
- | - | - | - | - | - | - | - | 49,852 | 44,626 | 40,056 |
Diluted (in shares) | ||||||||||
- | - | - | - | - | - | - | - | 50,823 | 45,942 | 40,056 |
Comprehensive loss: | ||||||||||
Comprehensive loss: | ||||||||||
Net Income (Loss) Available to Common Stockholders, Basic | ||||||||||
-290,055 | -176,061 | -88,096 | -21,003 | -83,313 | -98,600 | -108,408 | -58,648 | 180,356 | 37,290 | -64,012 |
Net unrealized holding gain (loss) on available-for-sale debt securities | ||||||||||
383 | 53 | -226 | 82 | 20 | -41 | -86 | 192 | -65 | -9 | - |
Comprehensive loss | ||||||||||
-289,672 | -176,008 | -88,322 | -20,921 | -83,293 | -98,641 | -108,494 | -58,456 | 180,291 | 37,281 | - |
Product revenue | ||||||||||
Collaboration revenue | ||||||||||
19,115 | 39,684 | 66,803 | 74,648 | 48,503 | 19,963 | 16,701 | 54,772 | 270,473 | 96,625 | - |
Research and development revenue | ||||||||||
Collaboration revenue | ||||||||||
4,753 | 35,905 | 72,079 | 34,971 | 41,147 | 32,287 | 18,764 | 9,149 | 12,595 | 20,147 | 20,249 |