| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||
Net loss | ||||||
-54,121 | -36,726 | -18,898 | -28,643 | -24,850 | - | - |
Net loss | ||||||
- | - | - | - | - | -10,833 | -5,270 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
278 | 127 | 126 | 23 | 11 | - | - |
Depreciation | ||||||
- | - | - | - | - | 5 | 10 |
Stock-based compensation expense | ||||||
5,672 | 4,788 | 2,880 | 3,077 | 2,108 | 698 | 236 |
Amortization of discount on investments | ||||||
- | - | - | - | 2 | - | - |
Noncash interest on convertible notes payable | ||||||
- | - | - | - | - | - | 91 |
Change in fair value of warrant liability | ||||||
- | - | - | - | - | -1,192 | -153 |
Amortization of debt issuance costs | ||||||
- | - | - | - | - | -4 | - |
Loss on disposal of fixed assets | ||||||
-42 | - | - | - | - | - | - |
Noncash lease expense | ||||||
225 | - | - | - | - | - | - |
Noncash lease liability | ||||||
-131 | - | - | - | - | - | - |
Amortization of debt issuance costs | ||||||
- | - | 4 | 7 | 7 | - | - |
Amortization of discount on investments | ||||||
8 | 79 | 28 | - | - | - | - |
Changes in operating assets and liabilities: | ||||||
Prepaid expenses and other current assets | ||||||
1,480 | 237 | 779 | -1,396 | 947 | 1,344 | 1,731 |
Accounts payable and accrued expenses | ||||||
890 | 4,285 | -2,121 | -629 | 3,540 | 1,385 | 189 |
Net cash used in operating activities | ||||||
-48,633 | -27,842 | -18,816 | -24,769 | -20,129 | - | - |
Net cash used in operating activities | ||||||
- | - | - | - | - | -8,589 | -6,628 |
Cash flows from investing activities | ||||||
Maturities of short-term investments | ||||||
6,994 | 20,000 | 3,922 | 4,474 | 1,743 | - | - |
Purchases of short-term investments | ||||||
2,725 | - | 24,892 | 2,434 | 7,705 | - | - |
Purchases of property and equipment | ||||||
388 | 83 | 450 | 644 | 352 | 33 | - |
Net cash provided by investing activities | ||||||
3,881 | 19,917 | -21,420 | 1,396 | -6,314 | - | - |
Purchases of property and equipment | ||||||
- | - | - | - | - | - | 17 |
Net cash provided by investing activities | ||||||
- | - | - | - | - | -33 | -17 |
Cash flows from financing activities | ||||||
Proceeds from exercise of stock options | ||||||
97 | 14 | 96 | 124 | 373 | 128 | 18 |
Proceeds from equity offerings, net of offering costs | ||||||
67,871 | 42,300 | - | - | - | - | - |
Principal payments of notes payable | ||||||
- | - | 5,247 | 2,128 | - | - | - |
Proceeds from public offerings, net of offering costs | ||||||
- | - | - | - | - | 41,202 | - |
Principal payments of notes payable | ||||||
- | - | - | - | 28,278 | 6,975 | - |
Proceeds from equity offerings, net of offering costs | ||||||
- | - | 52,547 | -167 | -206 | - | - |
Proceeds from short-term bank borrowings | ||||||
- | - | 193 | - | - | - | - |
Repayments of short-term bank borrowings | ||||||
- | 193 | - | - | - | - | - |
Proceeds from investor deposit | ||||||
- | - | - | - | - | - | 500 |
Proceeds from issuance of common stock, net of issuance costs | ||||||
- | - | - | - | - | - | 7,530 |
Net cash provided by/(used in) financing activities | ||||||
67,968 | 42,121 | 47,589 | -2,171 | 28,445 | - | - |
Net decrease in cash and cash equivalents | ||||||
23,216 | 34,196 | 7,353 | -25,544 | - | - | - |
Net decrease in cash and cash equivalents | ||||||
- | - | - | - | 2,002 | - | - |
Net cash provided by (used in) financing activities | ||||||
- | - | - | - | - | 48,305 | 8,048 |
Net decrease in cash and cash equivalents | ||||||
- | - | - | - | - | 39,683 | 1,403 |
Supplemental disclosure of cash flow information | ||||||
Financing in accounts payable and accrued expenses | ||||||
195 | 153 | - | - | - | - | - |
Cash paid for interest | ||||||
- | - | 184 | 460 | 468 | - | - |
Accrued equity offering costs | ||||||
- | - | - | - | 142 | - | - |
Conversion of preferred stock to common stock | ||||||
- | - | - | - | - | 70,340 | - |
Issuance of Series C Preferred Stock | ||||||
- | - | - | - | - | 500 | - |
Conversion of notes principal and accrued interest to preferred stock | ||||||
- | - | - | - | - | - | 2,761 |
Cash paid for interest | ||||||
- | - | - | - | - | 89 | - |
Financing arrangement with third-party vendor | ||||||
- | - | - | - | 584 | - | - |
Property and equipment in accounts payable and accrued expenses | ||||||
- | - | - | 134 | - | - | - |
Operating lease liability | ||||||
3,357 | - | - | - | - | - | - |
Operating right-of-use asset | ||||||
2,458 | - | - | - | - | - | - |