| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities: | ||||||||||||||||||||||||||||
Net loss | ||||||||||||||||||||||||||||
-86,655 | -72,376 | -54,273 | -45,695 | -40,912 | -28,272 | -27,568 | -27,869 | -14,709 | -17,895 | -16,350 | -18,339 | -17,846 | -19,722 | -19,421 | -22,061 | -21,914 | -18,417 | -18,741 | -15,446 | -11,940 | -10,387 | -8,617 | -11,038 | -13,656 | -11,233 | -29,397 | -8,012 | -4,217 |
Non-cash adjustments reconciling net loss to operating cash flows: | ||||||||||||||||||||||||||||
Depreciation | ||||||||||||||||||||||||||||
100 | 0 | 100 | 56 | 44 | 75 | 20 | 39 | 41 | 46 | 47 | 46 | 45 | 41 | 38 | 43 | 58 | 59 | 53 | 56 | 44 | 45 | 38 | 38 | 78 | 66 | 41 | 42 | 22 |
Accretion of discount on investments | ||||||||||||||||||||||||||||
520 | 603 | 854 | 1,047 | 917 | 563 | 381 | 214 | 162 | 34 | 54 | 107 | 71 | -1 | 19 | -11 | -14 | -657 | 69 | 152 | 99 | 95 | 126 | 146 | 167 | 0 | 0 | 0 | 0 |
Share-based compensation expense | ||||||||||||||||||||||||||||
21,567 | 16,711 | 15,106 | 12,589 | 11,131 | 4,262 | 4,058 | 3,874 | 3,660 | 1,318 | 1,479 | 2,223 | 1,766 | 2,538 | 2,760 | 2,288 | 3,038 | 2,342 | 2,804 | 2,792 | 2,316 | 2,228 | 2,591 | 1,285 | 946 | 726 | 852 | -217 | 462 |
Change in fair value of warrant liability | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -27 | -1,907 | 976 | 5,475 | 3,190 | 20,596 | 384 | -4,371 |
Change in restructuring costs | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 13 | 0 | 0 | 0 | 0 |
Lease incentive liability | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -19 | -16 | -18 |
Changes in operating assets and liabilities: | ||||||||||||||||||||||||||||
Other current assets | ||||||||||||||||||||||||||||
100 | -1,079 | 253 | 4,785 | 1,528 | 385 | 73 | -1,008 | -502 | 1,357 | -2 | 2,758 | -704 | 317 | 778 | -506 | -843 | 50 | 1,009 | -1,150 | -188 | 716 | 894 | -918 | 517 | -397 | 206 | 166 | -315 |
Other long-term assets | ||||||||||||||||||||||||||||
331 | 502 | -109 | 2,753 | 1,229 | 155 | 20 | 159 | 25 | -2,001 | 0 | -895 | -710 | 125 | 739 | 395 | 0 | - | - | - | - | -114 | 416 | 24 | 0 | - | - | - | - |
Accounts payable, accrued liabilities, deferred revenue and other liabilities | ||||||||||||||||||||||||||||
6,909 | 13,696 | 7,234 | 3,168 | -1,071 | 4,274 | 3,761 | 2,140 | 2,745 | 2,155 | -215 | 423 | -3,540 | 1,461 | -139 | 2,964 | 1,009 | -34 | 2,667 | 2,219 | -482 | 40 | -538 | 1,953 | -1,304 | -1,351 | 2,039 | -1,223 | 467 |
Cash flows used in operating activities | ||||||||||||||||||||||||||||
-59,004 | -41,902 | -32,874 | -38,468 | -34,482 | -20,795 | -20,172 | -21,181 | -7,948 | -13,766 | -15,091 | -17,617 | -18,232 | -16,123 | -18,298 | -16,644 | -16,952 | -16,030 | -15,870 | -9,039 | -9,775 | -8,587 | -9,617 | -5,746 | -8,798 | -7,712 | -5,195 | -9,208 | -7,340 |
Investing activities: | ||||||||||||||||||||||||||||
Purchases of short-term investments | ||||||||||||||||||||||||||||
230,384 | 72,113 | 245,449 | 85,208 | 127,458 | 100,020 | 4,439 | 48,516 | 102,820 | 5,455 | 8,679 | 23,114 | 63,310 | 3,008 | 17,581 | 27,883 | 21,797 | 63,930 | 0 | 5,045 | 35,979 | 1,500 | 3,027 | 1,518 | 4,423 | 42,683 | 3,334 | 6,370 | 16,021 |
Security deposit, restricted cash equivalents and marketable securities | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 9 | -33 | 56 |
Sales and maturities of short-term investments | ||||||||||||||||||||||||||||
108,381 | 66,506 | 117,534 | 79,350 | 92,250 | 36,423 | 33,237 | 22,750 | 17,742 | 16,500 | 22,450 | 30,938 | 22,100 | 21,785 | 31,157 | 34,248 | 21,530 | 19,250 | 17,300 | 13,100 | 4,880 | 11,480 | 9,000 | 7,550 | 7,043 | 2,251 | 6,432 | 14,358 | 16,097 |
Purchases of property, plant, and equipment | ||||||||||||||||||||||||||||
224 | 1,332 | 151 | 69 | 0 | - | - | - | - | - | - | - | - | 133 | 18 | 0 | 45 | 33 | -1 | 279 | 18 | 66 | 56 | 262 | 2 | 8 | 40 | 66 | 90 |
Cash flows used in investing activities | ||||||||||||||||||||||||||||
-122,227 | -6,939 | -128,066 | -5,927 | -35,208 | -63,683 | 28,762 | -25,766 | -85,078 | 11,044 | 13,771 | 7,744 | -41,210 | 18,644 | 13,558 | 6,365 | -312 | -44,713 | 17,301 | 7,776 | -31,117 | 9,914 | 5,917 | 5,770 | 2,618 | -40,404 | 3,049 | 7,955 | -70 |
Financing activities: | ||||||||||||||||||||||||||||
Proceeds from issuance of common stock, net of issuance costs | ||||||||||||||||||||||||||||
323,977 | 20 | 0 | 219,927 | 107,883 | 0 | 3 | 130,660 | 0 | 86,714 | 0 | 0 | 66,816 | 0 | 0 | 0 | 0 | 4 | 94,928 | 0 | 48,361 | 0 | 0 | 0 | 0 | - | - | - | - |
Proceeds from issuances under employee stock purchase plan | ||||||||||||||||||||||||||||
- | - | - | - | - | 240 | 0 | 202 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from exercise of common stock options and warrants | ||||||||||||||||||||||||||||
15,200 | 3,101 | 1,072 | 1,600 | 2,700 | 222 | 2,154 | 1,481 | 5,890 | 2,854 | 2,149 | 0 | 0 | 0 | 0 | 29 | 2,326 | 80 | 142 | 85 | 245 | 351 | 100 | 174 | 262 | 539 | 22 | 0 | 0 |
Proceeds from disgorgement of shareholders' short-swing profits | ||||||||||||||||||||||||||||
41 | 0 | 0 | 0 | 1,050 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Cash flows provided by financing activities | ||||||||||||||||||||||||||||
339,201 | 3,473 | 1,072 | 221,882 | 111,601 | 462 | 2,157 | 132,343 | 5,890 | 89,641 | 2,149 | 71 | 66,816 | 60 | 0 | 266 | 2,326 | 355 | 95,071 | 335 | 48,606 | 351 | 100 | 174 | 262 | 54,735 | 22 | 0 | 0 |
Increase in cash, cash equivalents and restricted cash | ||||||||||||||||||||||||||||
157,970 | -45,368 | -159,868 | 177,487 | 41,911 | -84,016 | 10,747 | 85,396 | -87,136 | 86,919 | 829 | -9,802 | 7,374 | 2,581 | -4,740 | -10,013 | -14,938 | -60,388 | 96,502 | -928 | 7,714 | 1,678 | -3,600 | 198 | -5,918 | 6,619 | -2,124 | -1,253 | -7,410 |
Supplemental disclosures of non-cash investing activities: | ||||||||||||||||||||||||||||
Purchases of property, plant, and equipment included within accounts payable and accrued liabilities | ||||||||||||||||||||||||||||
408 | - | - | - | 0 | - | - | - | - | - | - | - | 54 | - | - | - | 0 | - | - | - | 197 | - | 30 | -21 | 42 | - | - | - | - |