| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities: | ||||||||||||||||||||||||||||
Net loss | ||||||||||||||||||||||||||||
-258,999 | -213,256 | -169,152 | -142,447 | -124,621 | -98,418 | -88,041 | -76,823 | -67,293 | -70,430 | -72,257 | -75,328 | -79,050 | -83,118 | -81,813 | -81,133 | -74,518 | -64,544 | -56,514 | -46,390 | -41,982 | -43,698 | -44,544 | -65,324 | -62,298 | -52,859 | 0 | 0 | 0 |
Non-cash adjustments reconciling net loss to operating cash flows: | ||||||||||||||||||||||||||||
Depreciation | ||||||||||||||||||||||||||||
256 | 200 | 275 | 195 | 178 | 175 | 146 | 173 | 180 | 184 | 179 | 170 | 167 | 180 | 198 | 213 | 226 | 212 | 198 | 183 | 165 | 199 | 220 | 223 | 227 | 171 | 0 | 0 | 0 |
Accretion of discount on investments | ||||||||||||||||||||||||||||
3,024 | 3,421 | 3,381 | 2,908 | 2,075 | 1,320 | 791 | 464 | 357 | 266 | 231 | 196 | 78 | -7 | -663 | -613 | -450 | -337 | 415 | 472 | 466 | 534 | 439 | 313 | 167 | 0 | 0 | 0 | 0 |
Share-based compensation expense | ||||||||||||||||||||||||||||
65,973 | 55,537 | 43,088 | 32,040 | 23,325 | 15,854 | 12,910 | 10,331 | 8,680 | 6,786 | 8,006 | 9,287 | 9,352 | 10,624 | 10,428 | 10,472 | 10,976 | 10,254 | 10,140 | 9,927 | 8,420 | 7,050 | 5,548 | 3,809 | 2,307 | 1,823 | 0 | 0 | 0 |
Change in fair value of warrant liability | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 4,517 | 7,734 | 30,237 | 29,645 | 19,799 | 0 | 0 | 0 |
Change in restructuring costs | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 13 | 13 | 13 | 0 | 0 | 0 | 0 |
Lease incentive liability | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 |
Changes in operating assets and liabilities: | ||||||||||||||||||||||||||||
Other current assets | ||||||||||||||||||||||||||||
4,059 | 5,487 | 6,951 | 6,771 | 978 | -1,052 | -80 | -155 | 3,611 | 3,409 | 2,369 | 3,149 | -115 | -254 | -521 | -290 | -934 | -279 | 387 | 272 | 504 | 1,209 | 96 | -592 | 492 | -340 | 0 | 0 | 0 |
Other long-term assets | ||||||||||||||||||||||||||||
3,477 | 4,375 | 4,028 | 4,157 | 1,563 | 359 | -1,797 | -1,817 | -2,871 | -3,606 | -1,480 | -741 | 549 | 1,259 | 0 | 0 | 0 | - | - | - | - | 326 | 0 | 0 | 0 | - | - | - | - |
Accounts payable, accrued liabilities, deferred revenue and other liabilities | ||||||||||||||||||||||||||||
31,007 | 23,027 | 13,605 | 10,132 | 9,104 | 12,920 | 10,801 | 6,825 | 5,108 | -1,177 | -1,871 | -1,795 | 746 | 5,295 | 3,800 | 6,606 | 5,861 | 4,370 | 4,444 | 1,239 | 973 | 151 | -1,240 | 1,337 | -1,839 | -68 | 0 | 0 | 0 |
Cash flows used in operating activities | ||||||||||||||||||||||||||||
-172,248 | -147,726 | -126,619 | -113,917 | -96,630 | -70,096 | -63,067 | -57,986 | -54,422 | -64,706 | -67,063 | -70,270 | -69,297 | -68,017 | -67,924 | -65,496 | -57,891 | -50,714 | -43,271 | -37,018 | -33,725 | -32,748 | -31,873 | -27,451 | -30,913 | -29,455 | 0 | 0 | 0 |
Investing activities: | ||||||||||||||||||||||||||||
Purchases of short-term investments | ||||||||||||||||||||||||||||
633,154 | 530,228 | 558,135 | 317,125 | 280,433 | 255,795 | 161,230 | 165,470 | 140,068 | 100,558 | 98,111 | 107,013 | 111,782 | 70,269 | 131,191 | 113,610 | 90,772 | 104,954 | 42,524 | 45,551 | 42,024 | 10,468 | 51,651 | 51,958 | 56,810 | 68,408 | 0 | 0 | 0 |
Security deposit, restricted cash equivalents and marketable securities | ||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 |
Sales and maturities of short-term investments | ||||||||||||||||||||||||||||
371,771 | 355,640 | 325,557 | 241,260 | 184,660 | 110,152 | 90,229 | 79,442 | 87,630 | 91,988 | 97,273 | 105,980 | 109,290 | 108,720 | 106,185 | 92,328 | 71,180 | 54,530 | 46,760 | 38,460 | 32,910 | 35,073 | 25,844 | 23,276 | 30,084 | 39,138 | 0 | 0 | 0 |
Purchases of property, plant, and equipment | ||||||||||||||||||||||||||||
1,776 | 1,552 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | 196 | 96 | 77 | 356 | 329 | 362 | 419 | 402 | 386 | 328 | 312 | 116 | 204 | 0 | 0 | 0 |
Cash flows used in investing activities | ||||||||||||||||||||||||||||
-263,159 | -176,140 | -232,884 | -76,056 | -95,895 | -145,765 | -71,038 | -86,029 | -52,519 | -8,651 | -1,051 | -1,264 | -2,643 | 38,255 | -25,102 | -21,359 | -19,948 | -50,753 | 3,874 | -7,510 | -9,516 | 24,219 | -26,099 | -28,967 | -26,782 | -29,470 | 0 | 0 | 0 |
Financing activities: | ||||||||||||||||||||||||||||
Proceeds from issuance of common stock, net of issuance costs | ||||||||||||||||||||||||||||
543,924 | 327,830 | 327,810 | 327,813 | 238,546 | 130,663 | 217,377 | 217,374 | 86,714 | 153,530 | 66,816 | 66,816 | 66,816 | 0 | 4 | 94,932 | 94,932 | 143,293 | 143,289 | 48,361 | 48,361 | 0 | 0 | 0 | 0 | - | - | - | - |
Proceeds from issuances under employee stock purchase plan | ||||||||||||||||||||||||||||
- | - | - | - | - | 442 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from exercise of common stock options and warrants | ||||||||||||||||||||||||||||
20,973 | 8,473 | 5,594 | 6,676 | 6,557 | 9,747 | 12,379 | 12,374 | 10,893 | 5,003 | 2,149 | 0 | 29 | 2,355 | 2,435 | 2,577 | 2,633 | 552 | 823 | 781 | 870 | 887 | 1,075 | 997 | 823 | 561 | 0 | 0 | 0 |
Proceeds from disgorgement of shareholders' short-swing profits | ||||||||||||||||||||||||||||
41 | 1,050 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Cash flows provided by financing activities | ||||||||||||||||||||||||||||
565,628 | 338,028 | 335,017 | 336,102 | 246,563 | 140,852 | 230,031 | 230,023 | 97,751 | 158,677 | 69,096 | 66,947 | 67,142 | 2,652 | 2,947 | 98,018 | 98,087 | 144,367 | 144,363 | 49,392 | 49,231 | 887 | 55,271 | 55,193 | 55,019 | 54,757 | 0 | 0 | 0 |
Increase in cash, cash equivalents and restricted cash | ||||||||||||||||||||||||||||
130,221 | 14,162 | -24,486 | 146,129 | 54,038 | -75,009 | 95,926 | 86,008 | -9,190 | 85,320 | 982 | -4,587 | -4,798 | -27,110 | -90,079 | 11,163 | 20,248 | 42,900 | 104,966 | 4,864 | 5,990 | -7,642 | -2,701 | -1,225 | -2,676 | -4,168 | 0 | 0 | 0 |
Supplemental disclosures of non-cash investing activities: | ||||||||||||||||||||||||||||
Purchases of property, plant, and equipment included within accounts payable and accrued liabilities | ||||||||||||||||||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | 0 | - | - | - | 0 | - | - | - | 0 | - | 0 | 0 | 0 | - | - | - | - |