| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 | Dec'13 | Sep'13 | Jun'13 | Mar'13 | Sep'12 | Jun'12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Revenue | ||||||||||||||||||||||||||||||
License and collaboration revenues | ||||||||||||||||||||||||||||||
0 | - | 0 | 0 | 0 | - | 0 | 0 | - | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Total revenue | ||||||||||||||||||||||||||||||
2,358 | 3,335 | 6,268 | 5,280 | 4,703 | 12,926 | 0 | 0 | 0 | - | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Operating expenses | ||||||||||||||||||||||||||||||
Research and Development Expense | ||||||||||||||||||||||||||||||
220,334 | 182,866 | 146,684 | 122,948 | 108,453 | 93,872 | 82,358 | 72,214 | 63,347 | 58,085 | 58,793 | 61,417 | 64,896 | 68,487 | 67,448 | 65,905 | 58,740 | 48,959 | 41,122 | 33,445 | 29,318 | 26,071 | 23,315 | 21,921 | 19,282 | 19,797 | 19,726 | 17,886 | 0 | 0 | 0 |
General and administrative | ||||||||||||||||||||||||||||||
50,857 | 42,573 | 36,714 | 31,342 | 26,289 | 21,681 | 18,292 | 16,098 | 14,911 | 13,450 | 14,367 | 14,723 | 14,855 | 15,292 | 14,966 | 15,652 | 16,106 | 15,755 | 15,546 | 15,047 | 13,793 | 12,699 | 11,887 | 11,942 | 11,338 | 11,177 | 10,340 | 7,705 | 0 | 0 | 0 |
Restructuring costs | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 334 | 1,359 | 1,359 | 1,359 | 1,025 | 0 | 0 | 0 | - | - |
Total operating expenses | ||||||||||||||||||||||||||||||
271,191 | 225,439 | 183,398 | 154,290 | 134,742 | 115,553 | 100,650 | 88,312 | 78,258 | 71,535 | 73,160 | 76,140 | 79,751 | 83,779 | 82,414 | 81,557 | 74,846 | 64,714 | 56,668 | 48,492 | 43,111 | 39,104 | 36,561 | 35,222 | 31,979 | 31,999 | 30,066 | 25,591 | 0 | 0 | 0 |
Loss from operations | ||||||||||||||||||||||||||||||
-268,833 | -222,104 | -177,130 | -149,010 | -130,039 | -102,627 | -91,183 | -78,845 | -68,791 | -71,535 | -73,160 | -76,140 | -79,751 | -83,779 | -82,414 | -81,557 | -74,846 | -64,714 | -56,668 | -48,492 | -43,111 | -39,104 | -36,561 | -35,222 | -31,979 | -31,999 | -30,066 | -25,591 | 0 | 0 | 0 |
Other income, net | ||||||||||||||||||||||||||||||
9,834 | 8,848 | 7,978 | 6,563 | 5,418 | 4,209 | 3,142 | 2,022 | 1,498 | 1,105 | 903 | 812 | 701 | 661 | 601 | 424 | 328 | 170 | 127 | 168 | 171 | -77 | -387 | 51 | -716 | -1,084 | -768 | -1,160 | 0 | 0 | 0 |
Change in fair value of warrant liability | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 4,517 | 7,733 | 30,236 | 29,645 | 19,799 | 0 | 0 | 0 | - | - |
Loss before income taxes | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -52,882 | -47,444 | -22,765 | 0 | 0 | 0 |
Income tax benefit | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -23 | 129 | 87 | 0 | 0 | 0 |
Net Income (Loss) Attributable to Parent | ||||||||||||||||||||||||||||||
-258,999 | -213,256 | -169,152 | -142,447 | -124,621 | -98,418 | -88,041 | -76,823 | -67,293 | -70,430 | -72,257 | -75,328 | -79,050 | -83,118 | -81,813 | -81,133 | -74,518 | -64,544 | -56,514 | -46,390 | -41,982 | -43,698 | -44,543 | -65,324 | -62,298 | -52,859 | -47,573 | -22,852 | 0 | 0 | 0 |
Other Comprehensive Income (Loss), Securities, Available-for-Sale, Unrealized Holding Gain (Loss) Arising During Period, after Tax | ||||||||||||||||||||||||||||||
70 | 410 | 447 | 443 | 446 | 0 | -69 | -155 | -413 | -54 | -71 | -118 | 19 | -25 | 61 | 101 | 59 | 37 | -6 | -24 | 9 | 14 | 9 | 21 | -3 | -13 | 0 | 0 | 0 | - | - |
Comprehensive loss | ||||||||||||||||||||||||||||||
-258,929 | -212,846 | -168,705 | -142,004 | -124,175 | -98,418 | -88,110 | -76,978 | -67,706 | -70,484 | -72,328 | -75,446 | -79,031 | -83,143 | -81,752 | -81,032 | -74,459 | -64,507 | -56,520 | -46,414 | -41,973 | -43,684 | -44,534 | -65,303 | -62,301 | -52,872 | 0 | 0 | 0 | - | - |
Basic and diluted net loss per share (USD per share) | ||||||||||||||||||||||||||||||
-2.02 | -1.88 | -1.38 | -1.26 | -1.17 | -0.89 | -0.85 | -0.94 | -0.51 | -0.66 | -0.65 | -0.74 | -0.73 | -0.99 | -0.97 | -1.11 | -1.13 | - | -1.11 | -0.95 | -0.77 | - | - | -0.82 | -1.01 | - | - | -0.80 | - | -0.93 | -0.73 |
Loss per share, basic (in US$ per share) | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -0.64 | - | - | - | -2.95 | - | -0.42 | - | - |
Diluted net loss per share | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -0.72 | - | - | - | -2.95 | - | -0.68 | - | - |
Weighted average number of shares used in computing net loss per share, basic and diluted (shares) | ||||||||||||||||||||||||||||||
42,886 | 39,518 | 39,197 | 36,173 | 34,980 | 32,578 | 32,410 | 29,757 | 28,843 | 26,856 | 24,970 | 24,950 | 24,383 | 19,931 | 19,924 | 19,912 | 19,380 | 19,076 | 16,841 | 16,235 | 15,453 | - | - | 13,498 | 13,457 | - | - | 9,957 | - | 6,361 | 6,358 |
Weighted average number of shares used in computing net loss per share, basic | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 13,527 | - | - | - | 9,957 | - | 9,957 | - | - |
Weighted average number of shares used in computing net loss per share, diluted | ||||||||||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 14,717 | - | - | - | 9,957 | - | 10,078 | - | - |