| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | |||||||||
Net loss | |||||||||
-69,421 | -30,287 | -23,140 | -11,028 | 43,822 | -21,584 | -28,415 | -71,135 | -25,653 | -18,682 |
Adjustments to reconcile net loss to net cash used in operating activities: | |||||||||
Depreciation | |||||||||
- | - | - | 65 | - | - | - | - | - | - |
Depreciation and amortization | |||||||||
- | - | - | - | 1,002 | 1,309 | 1,506 | 1,008 | 525 | 509 |
Depreciation, amortization and other | |||||||||
1,182 | 974 | 155 | - | - | - | - | - | - | - |
Stock-based compensation expense | |||||||||
5,859 | 3,992 | 1,792 | 109 | 6,801 | 5,488 | 4,922 | 3,010 | 1,039 | 803 |
Amortization of debt discount and accretion related to debt | |||||||||
486 | 318 | 342 | 13 | - | - | - | - | - | - |
Change in common stock warrant fair value | |||||||||
3 | 951 | 128 | 3 | 16,773 | 9,344 | -2,325 | -51,216 | - | - |
Accretion of asset retirement obligations | |||||||||
72 | 39 | 0 | - | - | - | - | - | - | - |
Capitalized interest | |||||||||
0 | 125 | 0 | - | - | - | - | - | - | - |
Loss on extinguishment of debt | |||||||||
0 | -115 | -4,619 | - | - | - | - | - | - | - |
Loss on conversion of notes | |||||||||
- | - | - | 0 | - | - | - | - | - | - |
Loss on disposal of equipment | |||||||||
0 | -35 | -2 | -5 | -14 | 3 | 5 | - | - | - |
Loss on impairment of long-lived assets | |||||||||
22,139 | 0 | - | - | - | - | - | - | - | - |
Change in common stock warrant value | |||||||||
- | - | - | - | - | - | - | - | 4,358 | 5,166 |
(Gain) loss on sale of investments, property and equipment | |||||||||
- | - | - | - | - | - | - | - | 17 | 0 |
Changes in operating assets and liabilities: | |||||||||
Prepaid expenses | |||||||||
74 | 825 | 410 | 0 | - | - | - | - | - | - |
Accounts receivable, related party | |||||||||
168 | 240 | 0 | - | - | - | - | - | - | - |
Grants revenue receivable | |||||||||
2,771 | 4,351 | - | - | - | - | - | - | - | - |
Other current assets | |||||||||
- | - | 12 | -84 | - | - | - | - | - | - |
Other assets | |||||||||
286 | 450 | 81 | 0 | - | - | - | - | - | - |
Operating lease right-of-use assets and liabilities | |||||||||
2,816 | 0 | - | - | - | - | - | - | - | - |
Collaboration receivable/payable | |||||||||
- | - | - | - | -5,357 | -10,846 | - | - | - | - |
Collaboration receivable | |||||||||
- | - | - | - | - | - | 2,459 | - | - | - |
Collaboration receivable | |||||||||
- | - | - | - | - | - | - | 15,635 | - | - |
Prepaid expenses and other assets | |||||||||
- | - | - | - | 774 | -1,314 | 1,079 | 623 | 369 | 247 |
Accounts payable | |||||||||
652 | -1,736 | 1,209 | 557 | -1,349 | 385 | 781 | -1,481 | 2,137 | -32 |
Accrued clinical and development expenses | |||||||||
- | - | - | - | 836 | -1,446 | 1,694 | 1,285 | - | - |
Accrued clinical and development expenses | |||||||||
- | - | - | - | - | - | - | - | 2,026 | 821 |
Accrued liabilities | |||||||||
6,534 | 2,667 | 155 | 800 | 89 | 19 | 904 | 520 | 914 | -149 |
Other current liabilities | |||||||||
- | - | 20 | 0 | - | - | - | - | - | - |
Other liabilities | |||||||||
-36 | 224 | 318 | 0 | - | - | - | - | - | - |
Deferred revenue | |||||||||
7,775 | 26,136 | 895 | - | - | - | - | - | - | - |
Deferred rent | |||||||||
- | - | - | - | 112 | -3 | 28 | -115 | 95 | 241 |
Deferred revenue | |||||||||
- | - | - | 370 | -76,916 | -14,722 | 30,005 | 61,633 | - | 0 |
Net cash used in operating activities | |||||||||
-25,244 | -4,465 | -14,264 | - | - | - | - | - | -23,851 | -22,384 |
Cash flows from investing activities: | |||||||||
Net cash used in operating activities | |||||||||
- | - | - | -9,028 | -38,003 | -27,735 | 10,151 | 29,913 | - | - |
Cash received from merger transaction | |||||||||
- | - | 11,216 | 0 | - | - | - | - | - | - |
Purchases of property and equipment | |||||||||
9,649 | 5,722 | 1,101 | 101 | 109 | 224 | 158 | 482 | 528 | 108 |
Purchases of marketable securities | |||||||||
- | - | - | - | 56,793 | 44,911 | 101,968 | 93,745 | - | - |
Proceeds from sale of property and equipment | |||||||||
- | - | - | - | 0 | 0 | - | - | - | - |
Purchase of marketable securities | |||||||||
90,159 | 10,223 | 0 | - | - | - | - | - | 28,154 | 15,223 |
Increase in other assets | |||||||||
- | - | 400 | 588 | - | - | - | - | - | - |
Sales of marketable securities | |||||||||
60,084 | 0 | - | - | - | - | - | - | - | 37,454 |
Restricted cash | |||||||||
- | - | - | - | - | - | - | - | - | -12 |
Net cash used in investing activities | |||||||||
-39,724 | -15,945 | 9,715 | - | - | - | - | - | -9,182 | 22,135 |
Cash flows from financing activities: | |||||||||
Proceeds from issuance of common stock through Private Placement, net of issuance costs | |||||||||
10,469 | 0 | - | - | - | - | - | - | - | - |
Proceeds from issuance of common stock in a Public Offering, net of issuance costs | |||||||||
53,449 | 48,053 | - | - | - | - | - | - | - | - |
Payments of capital and finance lease obligations | |||||||||
-32 | 47 | - | - | - | - | - | - | - | - |
Proceeds from sales of marketable securities | |||||||||
- | - | - | - | 1,997 | 14,584 | 5,338 | 14,266 | 2,037 | - |
Proceeds from maturities of marketable securities | |||||||||
- | - | - | - | 65,223 | 53,878 | 80,495 | 33,285 | - | - |
Proceeds from maturities of marketable securities | |||||||||
- | - | - | - | - | - | - | - | 17,463 | - |
Net cash used in investing activities | |||||||||
- | - | - | -689 | 10,318 | 23,327 | -16,293 | -46,676 | - | - |
Payments of capital lease obligations | |||||||||
- | - | 43 | 44 | - | - | - | - | - | - |
Proceeds from issuance of long-term debt and warrants, net | |||||||||
0 | 4,537 | - | - | - | - | - | - | - | - |
Proceeds from issuance of long-term debt | |||||||||
- | - | 0 | 3,000 | - | - | - | - | - | - |
Repayment of long-term debt | |||||||||
0 | 3,605 | 2,400 | 400 | - | - | - | - | - | - |
Retirement of stock warrants | |||||||||
- | - | 208 | 0 | - | - | - | - | - | - |
Proceeds from issuance of related party debt | |||||||||
- | - | 2,685 | 4,630 | - | - | - | - | - | - |
Proceeds from stock option exercises | |||||||||
1,748 | 283 | 61 | 2 | - | - | - | - | - | - |
Deferred offering costs | |||||||||
- | - | - | - | - | - | - | - | - | 134 |
Proceeds from promissory note | |||||||||
- | - | 4,000 | 0 | - | - | - | - | - | - |
Proceeds from issuance of common stock and warrants, net of offering expenses | |||||||||
- | - | 57,648 | 0 | 28,883 | 5,520 | 2,392 | 21,910 | 30,224 | 140 |
Net cash provided by financing activities | |||||||||
- | - | - | 7,188 | 28,883 | 5,520 | 2,392 | 21,910 | - | - |
Net cash provided by financing activities | |||||||||
65,698 | 49,221 | 61,743 | - | - | - | - | - | 30,224 | 6 |
Net (decrease) increase in cash, cash equivalents, and restricted cash | |||||||||
730 | 28,811 | - | - | - | - | - | - | - | - |
Reconciliation of cash, cash equivalents and restricted cash | |||||||||
Net increase in cash and cash equivalents | |||||||||
- | - | 57,194 | -2,529 | 1,198 | 1,112 | -3,750 | 5,147 | -2,809 | -243 |
Supplemental Cash Flow Information | |||||||||
Cash paid for interest | |||||||||
684 | 629 | 250 | 230 | - | - | - | - | - | - |
Non-Cash Investing and Financing Activities | |||||||||
Fixed asset additions in accounts payable and accrued expenses | |||||||||
2,686 | 0 | - | - | - | - | - | - | - | - |
Deemed dividends on preferred stock | |||||||||
- | - | 958 | 1,573 | - | - | - | - | - | - |
Conversion of preferred stock | |||||||||
- | - | 26,829 | 0 | - | - | - | - | - | - |
Conversion of related party debt | |||||||||
- | - | 10,486 | 0 | - | - | - | - | - | - |
Conversion of warrant liability | |||||||||
- | - | 87 | 0 | - | - | - | - | - | - |
Capital lease additions to fixed assets | |||||||||
- | - | 291 | 110 | - | - | - | - | - | - |
Fixed asset additions in accounts payable | |||||||||
- | - | 382 | 20 | - | - | - | - | - | - |
Warrants issued with debt | |||||||||
- | - | - | 18 | - | - | - | - | - | - |
Change in unrealized gain (loss) in marketable securities | |||||||||
- | - | - | - | - | - | - | 12 | - | - |
Change in unrealized gain (loss) in marketable securities | |||||||||
- | - | - | - | - | - | - | - | -2 | 25 |