| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Research and development revenue | ||||||||||
- | - | - | 0 | - | - | - | - | - | - | - |
Total revenue | ||||||||||
22,270 | 13,285 | 3,395 | - | - | - | - | - | - | - | - |
Collaboration revenue | ||||||||||
- | - | - | - | 76,915 | 14,722 | 12,495 | 5,867 | 62 | 0 | - |
Grant revenue | ||||||||||
- | - | - | 1,880 | - | - | - | - | - | - | - |
Total revenue | ||||||||||
- | - | - | 1,880 | - | - | - | - | - | - | - |
Operating expenses: | ||||||||||
Research and development | ||||||||||
50,519 | 30,202 | 9,487 | 8,017 | 40,271 | 35,832 | 29,334 | 18,786 | 24,388 | 18,937 | 15,844 |
General and administrative | ||||||||||
20,077 | 14,082 | 11,755 | 4,482 | 9,716 | 10,141 | 9,185 | 7,080 | 5,710 | 4,971 | 5,480 |
Loss on impairment of in-process research and development | ||||||||||
22,123 | 0 | - | - | - | - | - | - | - | - | - |
Total operating expenses | ||||||||||
92,719 | 44,284 | 21,242 | 12,499 | 49,987 | 45,973 | 38,519 | 25,866 | 30,098 | 23,908 | 21,324 |
Loss from operations | ||||||||||
-70,449 | -30,999 | -17,847 | -10,619 | 26,928 | -31,251 | -26,024 | -19,999 | -30,036 | -23,908 | -21,324 |
Interest and other income, net | ||||||||||
2,323 | 751 | 51 | 19 | 125 | 121 | 136 | 80 | 25 | - | - |
Interest and other expense, net | ||||||||||
1,298 | 990 | 853 | - | - | - | - | - | - | - | - |
Interest expense | ||||||||||
- | - | - | 431 | - | - | - | - | - | - | - |
Other expense, net | ||||||||||
- | - | - | - | 16,769 | 9,344 | -2,325 | - | - | - | - |
Change in fair value of warrant liabilities | ||||||||||
3 | 951 | 128 | 3 | - | - | - | - | - | - | - |
Loss on conversion of notes | ||||||||||
- | - | 4,619 | 0 | - | - | - | - | - | - | - |
Interest income (expense), net | ||||||||||
- | - | - | - | - | - | - | - | - | 60 | -13 |
Other income (expense), net | ||||||||||
- | - | - | - | - | - | - | -51,216 | 4,358 | 5,166 | - |
Income (loss) before provision for income taxes | ||||||||||
- | - | - | - | 43,822 | -21,786 | -28,213 | -71,135 | -25,653 | - | - |
Provision for income taxes | ||||||||||
- | - | - | - | 0 | -202 | 202 | - | 0 | - | - |
Other income (expense) | ||||||||||
- | - | - | - | - | - | - | - | - | - | -2,311 |
Net loss | ||||||||||
- | - | -23,140 | -11,028 | 43,822 | -21,584 | -28,415 | -71,135 | -25,653 | -18,682 | -23,648 |
Deemed dividends on preferred stock | ||||||||||
- | - | 958 | 1,572 | - | - | - | - | - | - | - |
Net loss attributable to common shareholders | ||||||||||
-69,421 | -30,287 | -24,098 | -12,600 | - | - | - | - | - | - | -23,648 |
Net loss per share attributable to common shareholders: | ||||||||||
Basic | ||||||||||
- | - | - | - | 70,242 | 60,335 | 57,832 | 54,219 | 45,900 | 33,654 | - |
Diluted | ||||||||||
- | - | - | - | 73,483 | 63,386 | 57,832 | 54,219 | 45,900 | 33,654 | - |
Basic and diluted | ||||||||||
-1.86 | -1.02 | -2.11 | -59.04 | - | - | - | - | - | - | -1.21 |
Basic | ||||||||||
- | - | - | - | 0.62 | -0.36 | -0.49 | -1.31 | -0.56 | -0.56 | - |
Diluted | ||||||||||
- | - | - | - | 0.54 | -0.49 | -0.49 | -1.31 | -0.56 | -0.56 | - |
Weighted average number of shares used in net loss per share calculations: | ||||||||||
Basic and diluted | ||||||||||
37,770 | 29,601 | 11,400 | 213 | - | - | - | - | - | - | - |
Net loss attributable to common shareholders | ||||||||||
-69,421 | -30,287 | -24,098 | - | - | - | - | - | - | - | - |
Other comprehensive loss: | ||||||||||
Unrealized gain (loss) on available-for-sale securities | ||||||||||
18 | 0 | 0 | 0 | -8 | -41 | 17 | 12 | -2 | 25 | - |
Comprehensive loss | ||||||||||
-69,403 | -30,287 | -24,098 | -12,600 | 43,814 | -21,625 | -28,398 | -71,123 | -25,655 | -18,657 | - |
Weighted average number of shares used in per common share calculations: basic and diluted | ||||||||||
- | - | - | - | - | - | - | - | - | - | 19,594 |
Grant | ||||||||||
Total revenue | ||||||||||
2,771 | 6,002 | 987 | - | - | - | - | - | - | - | - |