| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Cash flow from operating activities: | ||||||
Net loss | ||||||
-276,213 | -67,698 | -57,010 | -10,380 | -22,946 | -16,829 | -12,700 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Stock-based compensation expense | ||||||
32,994 | 19,341 | 6,138 | 2,813 | 516 | 92 | 41 |
Depreciation | ||||||
1,900 | 1,600 | 1,300 | 1,111 | 965 | 712 | 478 |
Amortization of discount on investments | ||||||
1,619 | 279 | -85 | - | - | - | - |
Loss on disposal of equipment | ||||||
- | - | -4 | - | 4 | - | - |
Redeemable convertible preferred stock call option liability, net issued in connection with license and collaboration agreement | ||||||
- | - | - | - | - | 686 | - |
Change in fair value of redeemable convertible preferred stock call option liability, net | ||||||
- | - | - | - | 314 | 387 | 932 |
Change in operating assets and liabilities: | ||||||
Receivable from collaboration partner | ||||||
- | -1,013 | -43,987 | 45,000 | - | - | - |
Prepaid expenses and other current assets | ||||||
2,612 | 2,884 | 482 | 112 | 852 | 198 | 122 |
Operating lease right-of-use assets | ||||||
-2,618 | - | - | - | - | - | - |
Other long-term assets | ||||||
-290 | 296 | 59 | 24 | -39 | - | - |
Accounts payable | ||||||
3,064 | 671 | 367 | -434 | 1,301 | -340 | 63 |
Accrued liabilities | ||||||
11,665 | 8,945 | 2,968 | 3,250 | 2,940 | 1,540 | 378 |
Prepayment from collaboration partner | ||||||
12,973 | -8,541 | -4,432 | - | - | - | - |
Operating lease liabilities | ||||||
-2,838 | - | - | - | - | - | - |
Other long-term liabilities | ||||||
1,907 | -178 | -120 | -109 | 454 | -16 | 263 |
Deferred revenue | ||||||
- | -33,558 | -11,442 | 28,029 | -14,199 | 28,398 | - |
Net cash used in operating activities | ||||||
-241,769 | -64,815 | -9,838 | -20,856 | -32,100 | 13,658 | -12,531 |
Purchases of investments | ||||||
259,897 | 132,475 | 44,044 | 16,060 | - | - | - |
Sales of investments | ||||||
4,000 | 8,000 | 4,000 | - | - | - | - |
Maturities of investments | ||||||
78,000 | 28,000 | 4,000 | - | - | - | - |
Purchases of property and equipment | ||||||
3,264 | 3,373 | 1,517 | 1,083 | 1,446 | 716 | 1,169 |
Proceeds from sale of equipment | ||||||
- | - | 10 | - | 134 | - | - |
(Increase) decrease in restricted cash | ||||||
- | - | - | - | -60 | 260 | - |
Net cash provided by (used in) investing activities | ||||||
-181,161 | -99,848 | -37,551 | -17,143 | -1,252 | -976 | -1,169 |
Proceeds from issuance of common stock in follow-on offerings, net of issuance and financing costs | ||||||
271,224 | 181,863 | 133,862 | 61,148 | - | - | - |
Proceeds from exercise of stock options | ||||||
- | - | - | - | - | - | 318 |
Proceeds from issuance of common stock during IPO, net of issuance costs | ||||||
- | - | - | - | 55,780 | - | - |
Proceeds from exercise of stock options and employee stock purchase plan | ||||||
7,071 | 6,208 | 2,365 | 506 | 352 | 165 | - |
Payments of prior period offering costs | ||||||
- | - | 38 | 153 | - | - | - |
Net cash provided by financing activities | ||||||
278,295 | 188,071 | 136,189 | 61,501 | 101,969 | 29,055 | 10,953 |
Net increase in cash, cash equivalents and restricted cash | ||||||
-144,635 | 23,408 | 88,800 | 23,502 | 68,617 | 41,737 | -2,747 |
Non-cash investing and financing activities: | ||||||
Unpaid portion of property and equipment purchases included in period-end accounts payable and accrued liabilities | ||||||
9,756 | 468 | 283 | 103 | 61 | 91 | 103 |
Vesting of early exercised options and restricted stock | ||||||
15 | 53 | 184 | 272 | 177 | 104 | 17 |
Unpaid financing-related costs included in period-end accounts payable and accrued liabilities | ||||||
- | - | - | 38 | 153 | - | - |
Loan issued in connection with restricted stock purchase agreement | ||||||
- | - | - | - | - | - | 38 |
Accretion of redeemable convertible preferred stock to redemption value | ||||||
- | - | - | - | 98 | 158 | 179 |
Accretion of dividends on redeemable convertible preferred stock | ||||||
- | - | - | - | 5,151 | 2,864 | 1,087 |