| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flow from operating activities: | ||||||||||||||||||||
Net loss | ||||||||||||||||||||
-69,868 | -58,767 | -141,802 | -38,174 | -37,470 | -15,676 | -15,789 | -18,413 | -17,820 | -10,066 | -16,721 | -15,461 | -14,762 | 17,031 | -9,231 | -9,760 | -8,420 | -7,909 | -5,462 | -5,075 | -4,500 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||
Stock-based compensation expense | ||||||||||||||||||||
10,752 | 9,100 | 8,275 | 8,638 | 6,981 | 5,702 | 5,226 | 4,782 | 3,631 | 1,791 | 1,601 | 1,341 | 1,405 | 1,032 | 763 | 604 | 414 | 270 | 142 | 69 | 35 |
Depreciation | ||||||||||||||||||||
800 | 500 | 500 | 400 | 500 | 500 | 400 | 400 | 300 | 323 | 343 | 318 | 316 | 296 | 284 | 275 | 256 | 224 | 248 | 239 | 254 |
Amortization of discount on investments | ||||||||||||||||||||
418 | 585 | 378 | 364 | 292 | 152 | 74 | 55 | -2 | -23 | -21 | -19 | -22 | - | - | - | - | - | - | - | - |
Loss on disposal of equipment | ||||||||||||||||||||
-49 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -11 | 0 | 0 | 15 |
Change in fair value of redeemable convertible preferred stock call option liability, net | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 | 314 |
Change in operating assets and liabilities: | ||||||||||||||||||||
Receivable from collaboration partner | ||||||||||||||||||||
- | - | - | - | - | -2,565 | 2,565 | 0 | -1,013 | 1,013 | 0 | 0 | -45,000 | - | - | - | - | - | - | - | - |
Prepaid expenses and other current assets | ||||||||||||||||||||
-226 | 155 | 3,279 | -374 | -448 | 2,194 | -38 | 284 | 444 | 331 | 303 | -571 | 419 | 632 | -304 | -179 | -37 | 660 | 56 | -177 | 313 |
Operating lease right-of-use assets | ||||||||||||||||||||
-1,066 | -611 | -728 | -644 | -635 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Other long-term assets | ||||||||||||||||||||
- | -459 | 294 | -138 | 13 | 209 | 29 | -88 | 146 | -90 | 69 | -25 | 105 | - | - | - | - | - | - | - | - |
Accounts payable | ||||||||||||||||||||
-467 | -525 | 3,308 | -1,669 | 1,950 | 314 | -341 | 486 | 212 | 139 | 716 | -1,117 | 629 | -62 | 64 | -321 | -115 | 888 | -86 | 176 | 323 |
Accrued liabilities | ||||||||||||||||||||
-1,512 | -3,037 | 10,274 | 4,608 | -180 | 1,845 | 5,712 | 2,645 | -1,257 | 939 | 559 | 3,083 | -1,613 | 2,223 | 977 | 716 | -666 | 1,851 | 623 | 395 | 71 |
Prepayment from collaboration partner | ||||||||||||||||||||
- | 0 | 2,256 | 843 | 9,874 | -2,030 | -1,828 | -1,414 | -3,269 | - | - | - | - | - | - | - | - | - | - | - | - |
Operating lease liabilities | ||||||||||||||||||||
-504 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Other long-term liabilities | ||||||||||||||||||||
- | 0 | 3,297 | -698 | -692 | -45 | -45 | -45 | -43 | -2 | -32 | -42 | -44 | -34 | -32 | -32 | -11 | -49 | 136 | 60 | 307 |
Deferred revenue | ||||||||||||||||||||
- | - | - | - | - | -12,400 | -9,188 | -6,639 | -5,331 | -2,954 | -3,077 | -3,001 | -2,410 | 38,678 | -3,549 | -3,550 | -3,550 | -3,550 | -3,550 | -3,549 | -3,550 |
Net cash used in operating activities | ||||||||||||||||||||
-59,897 | -52,857 | -123,785 | -27,081 | -38,046 | -17,787 | -14,816 | -15,598 | -16,614 | -6,631 | -16,962 | -14,264 | 28,019 | 13,508 | -10,420 | -11,889 | -12,055 | -8,923 | -7,967 | -7,508 | -7,702 |
Purchases of investments | ||||||||||||||||||||
- | 114,105 | 104,199 | 8,896 | 32,697 | 84,054 | 8,826 | 7,846 | 31,749 | 0 | 8,022 | 4,002 | 32,020 | - | - | - | - | - | - | - | - |
Sales of investments | ||||||||||||||||||||
4,000 | 0 | 0 | 0 | 4,000 | - | - | - | - | 0 | 0 | 0 | 4,000 | - | - | - | - | - | - | - | - |
Maturities of investments | ||||||||||||||||||||
96,475 | 31,000 | 18,000 | 13,000 | 16,000 | 12,000 | 4,000 | 4,000 | 8,000 | - | - | - | - | - | - | - | - | - | - | - | - |
Purchases of property and equipment | ||||||||||||||||||||
12,627 | 1,286 | 285 | 880 | 813 | 356 | 661 | 1,168 | 1,188 | 600 | 300 | 432 | 185 | 229 | 88 | 204 | 562 | 72 | 93 | 719 | 562 |
Proceeds from sale of equipment | ||||||||||||||||||||
- | - | - | - | - | - | - | - | 39 | - | - | - | - | - | - | - | - | 0 | 0 | 0 | 134 |
Net cash provided by (used in) investing activities | ||||||||||||||||||||
87,848 | -84,391 | -86,484 | 3,224 | -13,510 | -72,410 | 2,513 | -5,053 | -24,898 | 3,410 | -8,322 | -4,434 | -28,205 | -16,289 | -88 | -204 | -562 | -72 | -93 | -659 | -428 |
Proceeds from issuance of common stock in follow-on offerings, net of issuance and financing costs | ||||||||||||||||||||
- | 0 | 0 | -261 | 271,485 | - | - | - | - | - | - | - | - | - | - | - | - | - | 224 | 29 | 99 |
Payments of financing related costs | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | 0 | 0 | 38 | - | - | 0 | 153 | - | - | - | - |
Proceeds from exercise of stock options and employee stock purchase plan | ||||||||||||||||||||
1,817 | 3,498 | 1,736 | 1,557 | 280 | 1,040 | 2,818 | 1,544 | 806 | 697 | 1,238 | 409 | 21 | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||
1,817 | 3,498 | 1,736 | 1,296 | 271,765 | 1,040 | 2,612 | 183,613 | 806 | 634 | 135,163 | 409 | -17 | 61,428 | 13 | 213 | -153 | 56,715 | -471 | 45,626 | 99 |
Net increase in cash, cash equivalents and restricted cash | ||||||||||||||||||||
29,768 | -133,750 | -208,533 | -22,561 | 220,209 | -89,157 | -9,691 | 162,962 | -40,706 | -2,587 | 109,879 | -18,289 | -203 | 58,647 | -10,495 | -11,880 | -12,770 | 47,720 | -8,531 | 37,459 | -8,031 |
Non-cash investing and financing activities: | ||||||||||||||||||||
Unpaid portion of property and equipment purchases included in period-end accounts payable and accrued liabilities | ||||||||||||||||||||
2,015 | 8,067 | 1,672 | -553 | 570 | 310 | -228 | 69 | 317 | 245 | -180 | 139 | 79 | 96 | -5 | -6 | 18 | 13 | 21 | -21 | 48 |
Vesting of early exercised options and restricted stock | ||||||||||||||||||||
- | 0 | 0 | 7 | 8 | 9 | 12 | 14 | 18 | 28 | 57 | 45 | 54 | 46 | 46 | 109 | 71 | 57 | 46 | 45 | 29 |
Unpaid financing-related costs | ||||||||||||||||||||
- | - | - | -251 | 262 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Unpaid portion of property and equipment purchases included in period-end accrued liabilities | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -219 | 229 |
Accretion of redeemable convertible preferred stock to redemption value | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 10 | 26 | 29 | 33 |
Accretion of dividends on redeemable convertible preferred stock | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 621 | 1,900 | 1,678 | 952 |