| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flow from operating activities: | ||||||||||||||||||||
Net loss | ||||||||||||||||||||
-308,611 | -276,213 | -233,122 | -107,109 | -87,348 | -67,698 | -62,088 | -63,020 | -60,068 | -57,010 | -29,913 | -22,423 | -16,722 | -10,380 | -35,320 | -31,551 | -26,866 | -22,946 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||
Stock-based compensation expense | ||||||||||||||||||||
36,765 | 32,994 | 29,596 | 26,547 | 22,691 | 19,341 | 15,430 | 11,805 | 8,364 | 6,138 | 5,379 | 4,541 | 3,804 | 2,813 | 2,051 | 1,430 | 895 | 516 | 0 | 0 | 0 |
Depreciation | ||||||||||||||||||||
2,200 | 1,900 | 1,900 | 1,800 | 1,800 | 1,600 | 1,423 | 1,366 | 1,284 | 1,300 | 1,273 | 1,214 | 1,171 | 1,111 | 1,039 | 1,003 | 967 | 965 | 0 | 0 | 0 |
Amortization of discount on investments | ||||||||||||||||||||
1,745 | 1,619 | 1,186 | 882 | 573 | 279 | 104 | 9 | -65 | -85 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Loss on disposal of equipment | ||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 4 | 0 | 0 | 0 |
Change in fair value of redeemable convertible preferred stock call option liability, net | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 314 | 0 | 0 | 0 |
Change in operating assets and liabilities: | ||||||||||||||||||||
Receivable from collaboration partner | ||||||||||||||||||||
- | - | - | - | - | -1,013 | 2,565 | 0 | 0 | -43,987 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Prepaid expenses and other current assets | ||||||||||||||||||||
2,834 | 2,612 | 4,651 | 1,334 | 1,992 | 2,884 | 1,021 | 1,362 | 507 | 482 | 783 | 176 | 568 | 112 | 140 | 500 | 502 | 852 | 0 | 0 | 0 |
Operating lease right-of-use assets | ||||||||||||||||||||
-3,049 | -2,618 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Other long-term assets | ||||||||||||||||||||
- | -290 | 378 | 113 | 163 | 296 | -3 | 37 | 100 | 59 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Accounts payable | ||||||||||||||||||||
647 | 3,064 | 3,903 | 254 | 2,409 | 671 | 496 | 1,553 | -50 | 367 | 166 | -486 | 310 | -434 | 516 | 366 | 863 | 1,301 | 0 | 0 | 0 |
Accrued liabilities | ||||||||||||||||||||
10,333 | 11,665 | 16,547 | 11,985 | 10,022 | 8,945 | 8,039 | 2,886 | 3,324 | 2,968 | 4,252 | 4,670 | 2,303 | 3,250 | 2,878 | 2,524 | 2,203 | 2,940 | 0 | 0 | 0 |
Prepayment from collaboration partner | ||||||||||||||||||||
- | 12,973 | 10,943 | 6,859 | 4,602 | -8,541 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Operating lease liabilities | ||||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Other long-term liabilities | ||||||||||||||||||||
- | 1,907 | 1,862 | -1,480 | -827 | -178 | -135 | -122 | -119 | -120 | -152 | -152 | -142 | -109 | -124 | 44 | 136 | 454 | 0 | 0 | 0 |
Deferred revenue | ||||||||||||||||||||
- | - | - | - | - | -33,558 | -24,112 | -18,001 | -14,363 | -11,442 | 30,190 | 29,718 | 29,169 | 28,029 | -14,199 | -14,200 | -14,199 | -14,199 | 0 | 0 | 0 |
Net cash used in operating activities | ||||||||||||||||||||
-263,620 | -241,769 | -206,699 | -97,730 | -86,247 | -64,815 | -53,659 | -55,805 | -54,471 | -9,838 | 10,301 | 16,843 | 19,218 | -20,856 | -43,287 | -40,834 | -36,453 | -32,100 | 0 | 0 | 0 |
Purchases of investments | ||||||||||||||||||||
- | 259,897 | 229,846 | 134,473 | 133,423 | 132,475 | 48,421 | 47,617 | 43,773 | 44,044 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Sales of investments | ||||||||||||||||||||
4,000 | 4,000 | 0 | 0 | 0 | - | - | - | - | 4,000 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Maturities of investments | ||||||||||||||||||||
158,475 | 78,000 | 59,000 | 45,000 | 36,000 | 28,000 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Purchases of property and equipment | ||||||||||||||||||||
15,078 | 3,264 | 2,334 | 2,710 | 2,998 | 3,373 | 3,617 | 3,256 | 2,520 | 1,517 | 1,146 | 934 | 706 | 1,083 | 926 | 931 | 1,446 | 1,446 | 0 | 0 | 0 |
Proceeds from sale of equipment | ||||||||||||||||||||
- | - | - | - | - | - | - | - | 0 | - | - | - | - | - | - | - | - | 134 | 0 | 0 | 0 |
Net cash provided by (used in) investing activities | ||||||||||||||||||||
-79,803 | -181,161 | -169,180 | -80,183 | -88,460 | -99,848 | -24,028 | -34,863 | -34,244 | -37,551 | -57,250 | -49,016 | -44,786 | -17,143 | -926 | -931 | -1,386 | -1,252 | 0 | 0 | 0 |
Proceeds from issuance of common stock in follow-on offerings, net of issuance and financing costs | ||||||||||||||||||||
- | 271,224 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 |
Payments of financing related costs | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 | - | - | 0 | 0 | - | - | - | - |
Proceeds from exercise of stock options and employee stock purchase plan | ||||||||||||||||||||
8,608 | 7,071 | 4,613 | 5,695 | 5,682 | 6,208 | 5,865 | 4,285 | 3,150 | 2,365 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||||||||||
8,347 | 278,295 | 275,837 | 276,713 | 459,030 | 188,071 | 187,665 | 320,216 | 137,012 | 136,189 | 196,983 | 61,833 | 61,637 | 61,501 | 56,788 | 56,304 | 101,717 | 101,969 | 0 | 0 | 0 |
Net increase in cash, cash equivalents and restricted cash | ||||||||||||||||||||
-335,076 | -144,635 | -100,042 | 98,800 | 284,323 | 23,408 | 109,978 | 229,548 | 48,297 | 88,800 | 150,034 | 29,660 | 36,069 | 23,502 | 12,575 | 14,539 | 63,878 | 68,617 | 0 | 0 | 0 |
Non-cash investing and financing activities: | ||||||||||||||||||||
Unpaid portion of property and equipment purchases included in period-end accounts payable and accrued liabilities | ||||||||||||||||||||
11,201 | 9,756 | 1,999 | 99 | 721 | 468 | 403 | 451 | 521 | 283 | 134 | 309 | 164 | 103 | 20 | 46 | 31 | 61 | 0 | 0 | 0 |
Vesting of early exercised options and restricted stock | ||||||||||||||||||||
- | 15 | 24 | 36 | 43 | 53 | 72 | 117 | 148 | 184 | 202 | 191 | 255 | 272 | 283 | 283 | 219 | 177 | 0 | 0 | 0 |
Unpaid financing-related costs | ||||||||||||||||||||
- | - | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Unpaid portion of property and equipment purchases included in period-end accrued liabilities | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 |
Accretion of redeemable convertible preferred stock to redemption value | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 98 | 0 | 0 | 0 |
Accretion of dividends on redeemable convertible preferred stock | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 5,151 | 0 | 0 | 0 |