| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 |
|---|---|---|---|---|---|---|
Collaboration and license revenue | ||||||
0 | 33,558 | 11,442 | 41,971 | 14,199 | 5,916 | - |
Operating expenses: | ||||||
Repurchase of royalty rights | ||||||
80,000 | - | - | - | - | - | - |
Research and development | ||||||
146,171 | 68,774 | 48,136 | 36,215 | 28,393 | 18,296 | 11,603 |
Selling, general and administrative | ||||||
61,663 | 38,435 | 21,973 | 16,289 | 9,019 | 4,838 | 2,029 |
Total operating expenses | ||||||
287,834 | 107,209 | 70,109 | 52,504 | 37,412 | 23,134 | 13,632 |
Loss from operations | ||||||
-287,834 | -73,651 | -58,667 | -10,533 | -23,213 | -17,218 | -13,632 |
Interest and other income, net | ||||||
11,621 | 5,953 | 1,657 | 153 | -47 | 2 | - |
Change in fair value of redeemable convertible preferred stock call option liability | ||||||
- | - | - | - | 314 | 387 | 932 |
Net loss | ||||||
-276,213 | -67,698 | -57,010 | -10,380 | -22,946 | -16,829 | -12,700 |
Other comprehensive income | ||||||
616 | 125 | -200 | 8 | - | - | - |
Comprehensive loss | ||||||
-275,597 | -67,573 | -57,210 | -10,372 | -22,946 | -16,829 | - |
Cumulative dividend relating to redeemable convertible preferred stock | ||||||
- | - | - | - | 5,151 | 2,864 | 1,087 |
Accretion of redeemable convertible preferred stock to redemption value | ||||||
- | - | - | - | 98 | 158 | 179 |
Net loss attributable to common stockholders | ||||||
- | - | - | - | -28,195 | -19,851 | -13,966 |
Net loss per share, basic and diluted | ||||||
-6.17 | -1.76 | -1.74 | -0.38 | -4.48 | -11.30 | -11.98 |
Weighted average number of shares used to compute net loss per share, basic and diluted | ||||||
44,765 | 38,386 | 32,832 | 27,475 | 6,292 | 1,756 | 1,165 |