| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Cash Flows from Operating Activities: | ||||||||||
Net loss | ||||||||||
37,012 | 21,111 | -142,542 | -141,090 | -88,929 | -60,542 | -46,090 | 5,025 | 37,571 | -7,968 | -51,038 |
Reconciliation of net income (loss) to net cash provided by (used in) operating activities: | ||||||||||
Share-based compensation expense | ||||||||||
75,262 | 58,068 | 42,522 | 28,464 | 28,392 | 10,382 | 6,819 | 5,479 | 2,918 | 3,133 | 5,539 |
Depreciation | ||||||||||
7,500 | 4,000 | 2,400 | - | - | - | - | - | - | - | - |
Depreciation and amortization | ||||||||||
- | - | - | 1,453 | 1,009 | 827 | 671 | 657 | 694 | 1,436 | 3,179 |
Amortization of debt discount | ||||||||||
18,922 | 17,552 | 10,937 | 0 | 0 | - | - | - | - | - | - |
Amortization of debt issuance costs | ||||||||||
1,389 | 1,326 | 848 | 0 | 0 | - | - | - | - | - | - |
Net (accretion of discounts) amortization of premiums on investments | ||||||||||
1,965 | -1,449 | -1,756 | -3,520 | -6,032 | -3,792 | -2,843 | -3,135 | -2,341 | -833 | - |
Change in fair value of equity security investments | ||||||||||
-12,987 | 0 | 0 | - | - | - | - | - | - | - | - |
Deferred revenues | ||||||||||
- | - | - | - | 10,231 | 0 | -2,919 | -34,242 | -37,027 | 62,490 | -2,914 |
Deferred rent | ||||||||||
- | - | - | -294 | -16 | 14 | 142 | 305 | 434 | 680 | 796 |
Gain on sales of assets, net | ||||||||||
- | - | - | 3,431 | 3,334 | 3,222 | 3,170 | 3,074 | 3,195 | 3,161 | 3,626 |
Fair value adjustment for auction rate security rights | ||||||||||
- | - | - | - | - | - | - | - | - | - | -815 |
Loss on sale of investments | ||||||||||
- | - | - | - | - | - | - | - | - | -186 | -1,086 |
Realized gain on sale of auction rate securities | ||||||||||
- | - | - | - | - | - | - | - | - | 1,320 | 124 |
Fair value adjustment of auction rate securities | ||||||||||
- | - | - | - | - | - | - | - | - | - | 1,047 |
Other-than-temporary impairment for auction rate securities | ||||||||||
- | - | - | - | - | - | - | - | - | - | -1,431 |
Cease-use expense | ||||||||||
- | - | - | -584 | -85 | 0 | 0 | 1,092 | 82 | 2,799 | 5,984 |
Other | ||||||||||
754 | -409 | -1,445 | - | - | - | - | - | - | - | - |
Change in operating assets and liabilities: | ||||||||||
Accounts receivable | ||||||||||
69,169 | 25,113 | 31,127 | 0 | 0 | - | - | - | - | - | - |
Inventory | ||||||||||
6,424 | 3,524 | 1,024 | 0 | 0 | - | - | - | - | - | - |
Reimbursements for tenant improvements | ||||||||||
- | - | - | 0 | - | - | - | - | - | - | - |
Other current assets | ||||||||||
- | - | - | - | 489 | - | - | - | - | - | - |
Accounts payable and accrued liabilities | ||||||||||
53,955 | 24,223 | 27,338 | 4,398 | 9,841 | 3,698 | -949 | -557 | 149 | 985 | -4,076 |
Other current assets and liabilities, net | ||||||||||
-21,879 | -2,657 | 3,994 | -1,383 | - | - | - | - | - | - | - |
Cease-use liability | ||||||||||
- | - | - | - | -610 | -418 | -590 | -263 | -7,502 | -4,537 | -9,851 |
Accounts receivable under collaboration agreements and other assets | ||||||||||
- | - | - | - | - | 1,671 | -13,528 | 12,878 | -2,813 | 4,278 | -2,449 |
Other liabilities | ||||||||||
- | - | - | - | -39 | 0 | 108 | 27 | 24 | -1,335 | -1,698 |
Net cash provided by (used in) operating activities | ||||||||||
152,054 | 101,364 | -94,331 | -106,181 | -37,997 | -47,140 | -29,607 | -35,294 | -698 | 49,943 | -53,095 |
Cash Flows from Investing Activities: | ||||||||||
Purchases of marketable securities | ||||||||||
797,169 | 545,962 | 583,408 | 298,776 | 449,052 | 257,544 | 145,328 | 166,313 | 139,099 | 89,787 | 16,800 |
Sales and maturities of marketable securities | ||||||||||
669,691 | 327,825 | 339,088 | 415,826 | 255,123 | 154,133 | 151,281 | 132,520 | 134,276 | 34,839 | 27,615 |
Purchases of equity securities | ||||||||||
68,855 | 0 | 0 | - | - | - | - | - | - | - | - |
Purchases of property and equipment | ||||||||||
14,748 | 24,812 | 6,940 | 4,108 | 1,934 | 1,612 | 545 | 971 | 750 | 315 | 35 |
Deposits and restricted cash | ||||||||||
- | - | - | - | -40 | 388 | 108 | 29 | -1,796 | -223 | -84 |
Proceeds from sales of property and equipment | ||||||||||
8 | 34 | 7 | 13 | 9 | 45 | 40 | 32 | 245 | 336 | 1,193 |
Net cash provided by investing activities | ||||||||||
-211,073 | -242,915 | -251,253 | 112,955 | -195,814 | -105,366 | 5,340 | -34,761 | -3,532 | -54,704 | 12,057 |
Cash Flows from Financing Activities: | ||||||||||
Issuance of common stock | ||||||||||
27,313 | 29,530 | 13,865 | 2,390 | 276,992 | 138,731 | 5,302 | 83,702 | 286 | 21,483 | 9,900 |
Proceeds from issuance of convertible senior notes, net | ||||||||||
0 | 0 | 502,781 | 0 | 0 | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||
27,313 | 29,530 | 516,646 | 2,390 | 276,992 | 138,731 | 5,302 | 83,702 | 286 | 21,483 | 9,900 |
Change in cash and cash equivalents and restricted cash | ||||||||||
-31,706 | -112,021 | 171,062 | 9,164 | 43,181 | -13,775 | -18,965 | 13,647 | -3,944 | 16,722 | -31,138 |
Supplemental Disclosure: | ||||||||||
Cash paid for interest | ||||||||||
11,644 | 11,644 | 6,242 | 0 | 0 | - | - | - | - | - | 0 |
Cash paid for income taxes | ||||||||||
507 | 0 | 0 | - | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Non-cash capital expenditures | ||||||||||
953 | 2,318 | 0 | 0 | - | - | - | - | - | - | - |