| Dec'18 | Dec'17 | Dec'16 | Dec'15 | |||
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-36,862 | -29,686 | -12,198 | -13,648 | |||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
276 | 206 | 138 | - | |||
Depreciation | ||||||
- | - | - | 40 | |||
Non-cash share-based compensation | ||||||
4,181 | 1,373 | 208 | 112 | |||
Accretion on marketable securities | ||||||
1,136 | - | - | - | |||
Deferred taxes | ||||||
-408 | -15 | - | - | |||
Unrealized foreign currency (gains) losses | ||||||
389 | - | - | - | |||
Realized investment (gains) losses | ||||||
6,741 | - | - | - | |||
Change in fair value of tranche obligation liability | ||||||
- | - | - | 4,333 | |||
Changes in operating assets and liabilities: | ||||||
Research and development tax credit receivable | ||||||
6,921 | -1,320 | 849 | - | |||
Prepaid expenses and other assets | ||||||
3,256 | 2,228 | 794 | 2,522 | |||
Accounts payable | ||||||
-9 | 1,773 | 419 | 384 | |||
Accrued expenses and other liabilities | ||||||
5,633 | 1,446 | 2,959 | 1,596 | |||
Net cash used in operating activities | ||||||
-45,632 | -25,796 | -10,117 | - | |||
Cash flows from investing activities: | ||||||
Investments marketable securities | ||||||
205,290 | - | - | - | |||
Proceeds from maturities of marketable securities | ||||||
70,000 | - | - | - | |||
Net cash used in operating activities | ||||||
- | - | - | -9,705 | |||
Purchases of property and equipment | ||||||
709 | 166 | 306 | 289 | |||
Net cash provided by (used in) investing activities | ||||||
-135,999 | -166 | -306 | - | |||
Cash flows from financing activities: | ||||||
Net cash used in investing activities | ||||||
- | - | - | -289 | |||
Proceeds of issuance of ordinary shares, net of issuance costs | ||||||
77,164 | 141,093 | 11,317 | 13,959 | |||
Net cash provided by financing activities | ||||||
77,164 | 141,093 | 11,317 | - | |||
Effect of exchange rate changes on cash, cash equivalents and restricted cash | ||||||
2,905 | 4,151 | -1,448 | - | |||
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||
-101,562 | 119,282 | -554 | - | |||
Supplemental disclosure of cash flow information: | ||||||
Cash paid for income taxes | ||||||
71 | - | - | - | |||
Net cash provided by financing activities | ||||||
- | - | - | 13,959 | |||
Effect of exchange rate changes on cash and cash equivalents | ||||||
- | - | - | -451 | |||
Net increase (decrease) in cash and cash equivalents | ||||||
- | - | - | 3,514 | |||
Reclassification of tranche obligation liability to additional paid-in capital | ||||||
- | - | - | 8,216 | |||