| Dec'18 | Dec'17 | Dec'16 | Dec'15 | |||
|---|---|---|---|---|---|---|
Operating expenses: | ||||||
Research and development | ||||||
31,585 | 20,502 | 10,165 | 7,175 | |||
General and administrative | ||||||
12,572 | 7,001 | 2,055 | 2,149 | |||
Total operating expenses | ||||||
44,157 | 27,503 | 12,220 | 9,324 | |||
Other income (expense): | ||||||
Interest and other income | ||||||
2,862 | 709 | 22 | 9 | |||
Other income (expense), net | ||||||
3,993 | -2,855 | - | - | |||
Change in fair value of tranche obligations | ||||||
- | - | - | 4,333 | |||
Total other income (expense), net | ||||||
6,855 | -2,146 | 22 | -4,324 | |||
Loss before provision for income taxes | ||||||
-37,302 | -29,649 | -12,198 | -13,648 | |||
Provision for income taxes | ||||||
-440 | 37 | 0 | 0 | |||
Net loss | ||||||
-36,862 | -29,686 | -12,198 | -13,648 | |||
Other comprehensive income (loss): | ||||||
Foreign currency translation adjustment | ||||||
-6,745 | 3,988 | -1,385 | -541 | |||
Change in net unrealized holding gains (losses) on available for sale securities | ||||||
2,081 | - | - | - | |||
Total other comprehensive loss | ||||||
-41,526 | -25,698 | -13,583 | -14,189 | |||
Basic and diluted net loss per ordinary share | ||||||
-1.26 | -1.63 | -1.36 | -2.46 | |||
Weighted average basic and diluted ordinary shares | ||||||
29,176 | 18,187 | 8,954 | 5,539 | |||