| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Licensing and collaboration revenue | ||||||||||
936 | 1,206 | 390 | 3,526 | - | - | - | - | - | - | - |
Grant revenue | ||||||||||
- | - | - | - | 32,358 | 6,642 | 1,093 | 1,687 | 1,872 | 2,079 | 934 |
Licensing and collaboration revenue | ||||||||||
- | - | - | - | 36,143 | 165,950 | 0 | 0 | - | - | - |
Total operating revenues | ||||||||||
936 | 12,474 | 28,711 | 35,800 | - | 172,592 | 1,093 | 1,687 | - | - | - |
Total operating revenues | ||||||||||
- | - | - | - | 68,501 | - | - | - | - | - | - |
Operating expenses: | ||||||||||
Research and development | ||||||||||
22,205 | 45,694 | 69,866 | 93,300 | 71,414 | 35,691 | 22,713 | 17,838 | 14,255 | 12,666 | 7,578 |
General and administrative | ||||||||||
23,865 | 29,218 | 31,726 | 33,226 | 30,689 | 19,328 | 9,521 | 7,108 | 5,679 | 6,074 | 3,705 |
Total operating expenses | ||||||||||
46,070 | 74,912 | 101,592 | 126,526 | 102,103 | 55,019 | 32,234 | 24,946 | 19,934 | 18,740 | 11,283 |
Loss from operations | ||||||||||
-45,134 | -62,438 | -72,881 | -90,758 | -33,602 | 117,573 | -31,141 | -23,259 | -18,062 | -16,661 | -10,349 |
Other income and expense: | ||||||||||
Miscellaneous (expense) income | ||||||||||
-19 | -102 | -126 | 32 | -14 | 60 | 91 | -62 | -26 | 99 | 142 |
Miscellaneous income (expense) | ||||||||||
- | - | - | - | - | 0 | 112 | - | - | - | - |
Miscellaneous income | ||||||||||
- | - | - | - | - | - | - | -38 | 5 | 71 | 19 |
Forgiveness of debt | ||||||||||
- | - | - | - | - | - | - | - | 0 | 0 | - |
Forgiveness of debt | ||||||||||
- | - | - | - | - | - | - | - | - | - | 0 |
Interest income | ||||||||||
2,226 | 2,029 | 616 | 237 | 78 | 86 | 12 | 14 | 11 | 75 | 132 |
Interest expense | ||||||||||
- | - | - | - | - | 26 | 33 | 38 | 42 | 47 | 9 |
Interest expense | ||||||||||
50 | 52 | 119 | 22 | 105 | - | - | - | - | - | - |
Other income, net | ||||||||||
2,157 | 1,875 | 371 | 247 | -41 | - | - | - | - | - | - |
Loss before taxes | ||||||||||
-42,977 | -60,563 | -72,510 | -90,511 | -33,643 | - | - | - | - | - | - |
Net loss before taxes | ||||||||||
- | - | - | - | - | 117,633 | -31,050 | -23,321 | -18,088 | - | - |
Income tax (expense) benefit | ||||||||||
12 | -6,968 | -559 | -5,356 | 6,738 | 21,616 | 130 | 0 | 0 | - | - |
Less net loss attributable to noncontrolling interest | ||||||||||
- | - | - | - | - | - | - | - | -1 | -349 | -233 |
Net loss | ||||||||||
-42,989 | -53,595 | -71,951 | -85,155 | -40,381 | 96,017 | -31,180 | -23,321 | -18,087 | -16,213 | -9,974 |
Basic and diluted loss per share | ||||||||||
- | - | - | - | - | 3.45 | -1.23 | -1.12 | - | - | - |
Diluted (loss) earnings per share | ||||||||||
- | - | - | - | - | 3.09 | -1.23 | -1.12 | - | - | - |
Basic and diluted average shares outstanding | ||||||||||
- | - | - | - | - | 27,838 | 25,275 | 20,779 | - | - | 3,159 |
Diluted average shares outstanding | ||||||||||
- | - | - | - | - | 31,025 | 25,275 | 20,779 | - | - | 3,159 |
Net loss | ||||||||||
- | - | - | - | - | - | - | - | -18,088 | -16,562 | -10,207 |
Basic and diluted loss per share (in dollars per share) | ||||||||||
-1.15 | -1.44 | -2.30 | -2.94 | -1.41 | - | - | - | -2.98 | -4.84 | -3.16 |
Basic and diluted average shares outstanding (in shares) | ||||||||||
37,294 | 37,191 | 31,304 | 28,979 | 28,586 | - | - | - | 6,064 | 3,352 | - |
Grant | ||||||||||
Total operating revenues | ||||||||||
0 | 11,268 | 28,321 | 32,200 | - | - | - | - | - | - | - |