| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenue | ||||||||||||||||||||
12,916 | 10,936 | 10,616 | 11,118 | 10,433 | 7,880 | 7,408 | 7,677 | 7,469 | 6,668 | 7,317 | 5,917 | 6,215 | 5,627 | 4,869 | 4,206 | 1,777 | 1,693 | 1,688 | 1,377 | 1,286 |
Operating expenses: | ||||||||||||||||||||
Research and development | ||||||||||||||||||||
34,650 | 31,731 | 27,513 | 25,460 | 23,709 | 19,918 | 23,237 | 23,467 | 22,493 | 21,170 | 17,481 | 15,565 | 13,431 | 11,331 | 7,861 | 7,423 | 5,225 | 4,375 | 3,458 | 1,966 | 1,371 |
General and administrative | ||||||||||||||||||||
11,314 | 8,976 | 8,431 | 13,118 | 10,533 | 8,708 | 8,270 | 7,805 | 7,406 | 10,213 | 5,711 | 6,369 | 5,732 | 5,118 | 4,705 | 3,729 | 3,246 | 2,809 | 1,531 | 2,833 | 1,110 |
Total operating expenses | ||||||||||||||||||||
45,964 | 40,707 | 35,944 | 38,578 | 34,242 | 28,626 | 31,507 | 31,272 | 29,899 | 31,383 | 23,192 | 21,934 | 19,163 | 16,449 | 12,566 | 11,152 | 8,471 | 7,184 | 4,989 | 4,799 | 2,481 |
Operating loss | ||||||||||||||||||||
-33,048 | -29,771 | -25,328 | -27,460 | -23,809 | -20,746 | -24,099 | -23,595 | -22,430 | -24,715 | -15,875 | -16,017 | -12,948 | -10,822 | -7,697 | -6,946 | -6,694 | -5,491 | -3,301 | -3,422 | -1,195 |
Interest income | ||||||||||||||||||||
1,242 | 1,495 | 1,694 | 1,777 | 1,869 | 1,680 | 1,397 | 1,376 | 1,074 | 752 | 519 | 424 | 317 | 259 | 215 | 46 | 5 | - | - | - | - |
Loss before income taxes | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -5,491 | -3,301 | -3,422 | -1,195 |
Income tax benefit | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -246 | -282 | -382 | -102 |
Net loss | ||||||||||||||||||||
-31,806 | -28,276 | -23,634 | -25,683 | -21,940 | -19,066 | -22,702 | -22,219 | -21,356 | -23,963 | -15,356 | -15,593 | -12,631 | -10,563 | -7,482 | -6,900 | -6,689 | -5,245 | -3,019 | -3,040 | -1,093 |
Net loss per share, basic and diluted | ||||||||||||||||||||
-0.63 | -0.57 | -0.49 | -0.56 | -0.49 | -0.43 | -0.53 | -0.52 | -0.51 | -0.61 | -0.44 | -0.45 | -0.36 | -0.31 | -0.22 | -0.36 | -9.89 | -9.57 | -10.27 | -2.37 | -0.85 |
Weighted average shares outstanding, basic and diluted | ||||||||||||||||||||
50,491 | 49,350 | 48,554 | 45,814 | 45,234 | 44,215 | 43,161 | 42,836 | 42,043 | 39,155 | 35,189 | 34,916 | 34,723 | 34,507 | 34,316 | 19,121 | 676 | 548 | 294 | 1,284 | 1,284 |
Other comprehensive loss: | ||||||||||||||||||||
Unrealized gain on marketable securities | ||||||||||||||||||||
112 | -75 | 81 | 196 | 87 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Comprehensive loss | ||||||||||||||||||||
-31,694 | -28,351 | -23,553 | -25,487 | -21,853 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |