| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenue | ||||||||||||||||||||
45,586 | 43,103 | 40,047 | 36,839 | 33,398 | 30,434 | 29,222 | 29,131 | 27,371 | 26,117 | 25,076 | 22,628 | 20,917 | 16,479 | 12,545 | 9,364 | 6,535 | 6,044 | 0 | 0 | 0 |
Operating expenses: | ||||||||||||||||||||
Research and development | ||||||||||||||||||||
119,354 | 108,413 | 96,600 | 92,324 | 90,331 | 89,115 | 90,367 | 84,611 | 76,709 | 67,647 | 57,808 | 48,188 | 40,046 | 31,840 | 24,884 | 20,481 | 15,024 | 11,170 | 0 | 0 | 0 |
General and administrative | ||||||||||||||||||||
41,839 | 41,058 | 40,790 | 40,629 | 35,316 | 32,189 | 33,694 | 31,135 | 29,699 | 28,025 | 22,930 | 21,924 | 19,284 | 16,798 | 14,489 | 11,315 | 10,419 | 8,283 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||||||||||
161,193 | 149,471 | 137,390 | 132,953 | 125,647 | 121,304 | 124,061 | 115,746 | 106,408 | 95,672 | 80,738 | 70,112 | 59,330 | 48,638 | 39,373 | 31,796 | 25,443 | 19,453 | 0 | 0 | 0 |
Operating loss | ||||||||||||||||||||
-115,607 | -106,368 | -97,343 | -96,114 | -92,249 | -90,870 | -94,839 | -86,615 | -79,037 | -69,555 | -55,662 | -47,484 | -38,413 | -32,159 | -26,828 | -22,432 | -18,908 | -13,409 | 0 | 0 | 0 |
Interest income | ||||||||||||||||||||
6,208 | 6,835 | 7,020 | 6,723 | 6,322 | 5,527 | 4,599 | 3,721 | 2,769 | 2,012 | 1,519 | 1,215 | 837 | 525 | 0 | 0 | 0 | - | - | - | - |
Loss before income taxes | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -13,409 | 0 | 0 | 0 |
Income tax benefit | ||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -1,012 | 0 | 0 | 0 |
Net loss | ||||||||||||||||||||
-109,399 | -99,533 | -90,323 | -89,391 | -85,927 | -85,343 | -90,240 | -82,894 | -76,268 | -67,543 | -54,143 | -46,269 | -37,576 | -31,634 | -26,316 | -21,853 | -17,993 | -12,397 | 0 | 0 | 0 |
Net loss per share, basic and diluted | ||||||||||||||||||||
-0.63 | -0.57 | -0.49 | -0.56 | -0.49 | -0.43 | -0.53 | -0.52 | -0.51 | -0.61 | -0.44 | -0.45 | -0.36 | -0.31 | -0.22 | -0.36 | -9.89 | -9.57 | -10.27 | -2.37 | -0.85 |
Weighted average shares outstanding, basic and diluted | ||||||||||||||||||||
50,491 | 49,350 | 48,554 | 45,814 | 45,234 | 44,215 | 43,161 | 42,836 | 42,043 | 39,155 | 35,189 | 34,916 | 34,723 | 34,507 | 34,316 | 19,121 | 676 | 548 | 294 | 1,284 | 1,284 |
Other comprehensive loss: | ||||||||||||||||||||
Unrealized gain on marketable securities | ||||||||||||||||||||
314 | 289 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Comprehensive loss | ||||||||||||||||||||
-109,085 | -99,244 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |