| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenue: | ||||||||||
Grant and other | ||||||||||
- | - | - | - | 2,906 | - | - | - | - | - | - |
Government contract | ||||||||||
- | - | - | - | 33,344 | 26,213 | 17,708 | 20,671 | 14,688 | 343 | 325 |
Research and development collaborations | ||||||||||
- | - | - | - | - | 4,446 | 3,207 | 1,405 | 0 | 0 | - |
Total revenue | ||||||||||
18,662 | 34,288 | 31,176 | 15,353 | 36,250 | 30,659 | 20,915 | 22,076 | 14,688 | 343 | - |
Expenses: | ||||||||||
Cost of government contracts revenue | ||||||||||
- | - | - | - | - | - | - | 14,692 | 7,003 | 0 | - |
Research and development | ||||||||||
113,842 | 173,797 | 168,435 | 237,939 | 162,644 | 94,422 | 58,530 | 26,907 | 18,364 | 28,032 | 25,780 |
Gain on Catalent transaction | ||||||||||
9,016 | - | - | - | - | - | - | - | - | - | - |
General and administrative | ||||||||||
34,417 | 34,409 | 34,451 | 46,527 | 30,842 | 19,928 | 14,819 | 10,142 | 10,900 | 10,805 | 11,928 |
Total expenses | ||||||||||
139,243 | 208,206 | 202,886 | 284,466 | 193,486 | 114,350 | 73,349 | 51,741 | 36,267 | 38,837 | 37,708 |
Loss from operations | ||||||||||
-120,581 | -173,918 | -171,710 | -269,113 | -157,236 | -83,691 | -52,434 | -29,665 | -21,579 | -38,494 | -37,383 |
Other income (expense): | ||||||||||
Investment income | ||||||||||
1,512 | 2,674 | 1,946 | 2,143 | 660 | 286 | 187 | 165 | 136 | 189 | 285 |
Interest expense | ||||||||||
13,612 | 13,612 | 14,072 | 12,965 | 241 | 157 | 160 | 32 | 9 | 9 | 786 |
Other income (expense) | ||||||||||
-13 | 108 | 67 | -31 | -120 | 0 | 182 | 45 | -26 | 485 | - |
Impairment of short-term investments | ||||||||||
- | - | - | - | - | - | - | - | - | - | 1,338 |
Realized gains on marketable securities | ||||||||||
- | - | - | - | - | 615 | 0 | 879 | 0 | 0 | 848 |
Change in fair value of warrant liability | ||||||||||
- | - | - | - | - | - | -267 | -101 | 2,474 | 1,671 | -1,972 |
Loss from operations before income tax expense | ||||||||||
- | - | - | - | - | - | -51,958 | -28,507 | -18,952 | -36,158 | -40,346 |
Income tax expense | ||||||||||
- | - | - | - | - | - | 25 | 0 | 412 | 450 | - |
Net loss | ||||||||||
-132,694 | -184,748 | -183,769 | -279,966 | -156,937 | -82,947 | -51,983 | -28,507 | -19,364 | -35,708 | -40,346 |
Basic and diluted net loss per share | ||||||||||
-5.51 | -9.99 | -12.56 | -1.03 | -0.60 | -0.37 | -0.31 | -0.22 | -0.17 | -0.34 | -0.47 |
Basic and diluted weighted average number of common shares outstanding | ||||||||||
24,100 | 18,488 | 14,633 | 270,802 | 262 | 225 | 169,658 | 131 | 113 | 104 | 85,555 |
Government Contract [Member] | ||||||||||
Total revenue | ||||||||||
7,500 | - | - | 2,184 | - | - | - | - | - | - | - |
Grant and other [Member] | ||||||||||
Total revenue | ||||||||||
11,162 | 34,288 | 31,176 | 13,169 | - | - | - | - | - | - | - |