| Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Operating activities: | |||||||||||||||
Net loss | |||||||||||||||
-23,676 | -27,519 | -30,558 | -33,544 | -37,380 | -38,744 | -41,169 | -39,146 | -34,765 | -32,140 | -28,230 | -24,631 | -20,467 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | |||||||||||||||
Depreciation, Depletion and Amortization, Nonproduction | |||||||||||||||
- | 0 | 0 | 0 | - | 0 | 0 | 0 | - | 271 | 238 | 213 | 192 | 0 | 0 | 0 |
Stock-based compensation | |||||||||||||||
2,983 | 3,383 | 3,731 | 4,409 | 4,693 | 4,749 | 4,765 | 4,167 | 3,241 | 2,465 | 1,497 | 976 | 563 | 0 | 0 | 0 |
Amortization of right-of-use asset | |||||||||||||||
415 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Loss on disposal of fixed assets | |||||||||||||||
-128 | -128 | -95 | 0 | -107 | -107 | -107 | -107 | 0 | 0 | 0 | 0 | -13 | 0 | 0 | 0 |
Change in fair value of warrant liability | |||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 466 | 0 | 0 | 0 |
Accretion of investment discount, net | |||||||||||||||
2 | 32 | 45 | 47 | 50 | 26 | 0 | -10 | -18 | -53 | -81 | -103 | -125 | 0 | 0 | 0 |
Amortization of debt discount | |||||||||||||||
70 | 78 | 85 | 48 | 37 | 40 | 44 | 43 | 42 | 41 | 47 | 59 | 70 | 0 | 0 | 0 |
Change in operating assets and liabilities: | |||||||||||||||
Accounts receivable, net | |||||||||||||||
-585 | -2,537 | -2,602 | -724 | -3,353 | 260 | 1,292 | 1,518 | 4,223 | 2,515 | 1,757 | 1,035 | 0 | 0 | 0 | 0 |
Accounts receivable from related party | |||||||||||||||
- | - | - | - | - | - | - | - | -515 | -515 | -585 | -894 | -121 | 0 | 0 | 0 |
Inventory | |||||||||||||||
-12 | -258 | -105 | -389 | 162 | 1,044 | 1,095 | 939 | 591 | 473 | 270 | 374 | 464 | 0 | 0 | 0 |
Other current assets | |||||||||||||||
-411 | -897 | -1,001 | -494 | -98 | -95 | 152 | 183 | 470 | -1,852 | 492 | 731 | 985 | 0 | 0 | 0 |
Accounts payable | |||||||||||||||
-543 | -789 | -396 | -1,141 | 70 | 225 | 841 | 1,481 | 624 | 0 | 0 | 0 | - | - | - | - |
Accounts payable and accrued expenses | |||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 |
Accrued compensation | |||||||||||||||
-2,985 | -1,963 | -1,039 | -845 | -689 | 0 | -249 | 276 | 1,997 | 1,987 | 2,145 | 1,305 | 1,247 | 0 | 0 | 0 |
Deferred revenue | |||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 171 | 121 | 0 | 0 | 0 |
Accrued clinical expenses | |||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 |
Deferred revenue | |||||||||||||||
- | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Lease liabilities, net | |||||||||||||||
-364 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Other current and long-term liabilities | |||||||||||||||
- | 0 | 0 | 0 | - | 0 | 0 | 0 | - | 0 | 0 | 0 | - | 0 | 0 | 0 |
Net cash used in operating activities | |||||||||||||||
-22,866 | -23,402 | -24,706 | -28,472 | -29,432 | -33,214 | -34,940 | -32,873 | -30,624 | -27,202 | -25,113 | -22,739 | -19,368 | 0 | 0 | 0 |
Purchases of short-term investments | |||||||||||||||
- | - | - | - | - | - | - | - | 94,613 | 80,317 | 68,846 | 41,918 | 18,897 | 0 | 0 | 0 |
Maturities of short-term investments | |||||||||||||||
2,550 | 8,149 | 9,150 | 9,149 | 29,901 | 56,602 | 84,601 | 94,602 | 73,800 | 50,800 | 27,800 | 22,150 | 25,450 | 0 | 0 | 0 |
Purchases of property and equipment | |||||||||||||||
194 | 459 | 645 | 943 | 1,282 | 1,006 | 1,141 | 1,020 | 1,043 | 997 | 848 | 688 | 352 | 0 | 0 | 0 |
Net cash provided by investing activities | |||||||||||||||
2,356 | 7,691 | 398 | -896 | 19,517 | 32,197 | 52,780 | 23,998 | -21,856 | -30,514 | -41,894 | -20,456 | 6,201 | 0 | 0 | 0 |
Financing activities: | |||||||||||||||
Proceeds from issuance of common stock and warrants, net of issuance costs | |||||||||||||||
23,377 | 8,509 | 18,616 | 10,430 | 9,823 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Proceeds from long-term loan, net of issuance costs | |||||||||||||||
10,000 | 10,000 | 10,000 | 10,000 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Proceeds from sale of common stock upon exercise of stock options | |||||||||||||||
1 | 16 | 23 | 26 | 53 | 176 | 178 | 212 | 184 | 47 | 1,092 | 1,064 | 1,066 | 0 | 0 | 0 |
Net cash provided by financing activities | |||||||||||||||
13,378 | 13,539 | 13,609 | 20,574 | 9,994 | 10,486 | 545 | 641 | 613 | 67,475 | 68,505 | 82,784 | 82,786 | 0 | 0 | 0 |
Net (decrease) increase in cash and cash equivalents | |||||||||||||||
-7,132 | -2,172 | -10,699 | -8,794 | 79 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Net increase (decrease) in cash and cash equivalents | |||||||||||||||
- | - | - | - | - | - | - | - | -51,867 | 9,759 | 1,498 | 39,589 | 69,619 | 0 | 0 | 0 |
Supplemental cash flow information: | |||||||||||||||
Interest paid | |||||||||||||||
719 | 869 | 898 | 698 | 642 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Interest paid | |||||||||||||||
- | - | - | - | - | - | - | - | - | - | 531 | 525 | 527 | 0 | 0 | 0 |
Property and equipment in accounts payable | |||||||||||||||
32 | 95 | 95 | 159 | 201 | 63 | 93 | 0 | 83 | 266 | 115 | 269 | 140 | 0 | 0 | 0 |
Unpaid issuance costs | |||||||||||||||
0 | 385 | 627 | 276 | 250 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |