| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | |
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
86,372 | 59,978 | 63,386 | -44,703 | - | - | |
Net loss | ||||||
- | - | - | - | -39,748 | -28,648 | |
Adjustments to reconcile net loss to net cash used in operating activities | ||||||
Stock-based compensation expense | ||||||
8,759 | 7,483 | 7,321 | 5,956 | 4,640 | 2,644 | |
Licensing and consultant fees paid in common stock | ||||||
- | - | - | - | - | 2,364 | |
Non-cash interest expense | ||||||
3,683 | 397 | 408 | 371 | 166 | 103 | |
Change in fair value of derivative liability | ||||||
4,310 | - | - | - | - | - | |
Depreciation and amortization expense | ||||||
2,530 | 2,286 | 1,625 | 881 | 754 | 547 | |
Revaluation of preferred stock warrants | ||||||
- | - | - | - | - | 380 | |
Loss on extinguishment of debt | ||||||
- | - | - | - | - | -57 | |
(Gain)/loss on disposal of property and equipment | ||||||
-7 | - | 5 | -1,269 | 3 | -4 | |
Purchase of premium on marketable securities | ||||||
- | - | 3 | 37 | 338 | 133 | |
Amortization of premium on marketable securities | ||||||
- | - | 17 | 186 | 283 | 24 | |
Changes in operating assets and liabilities: | ||||||
Accounts receivable from related party | ||||||
- | - | - | - | - | -19 | |
Accounts receivable | ||||||
2,347 | -25 | -24 | 57 | -136 | 79 | |
Prepaid expenses and other current assets | ||||||
518 | 260 | -45 | -924 | 53 | 36 | |
Inventory | ||||||
737 | 95 | 9 | -21 | 1 | 133 | |
Operating lease assets | ||||||
-733 | - | - | - | - | - | |
Accounts payable | ||||||
124 | -796 | 932 | -159 | 348 | 507 | |
Accrued expenses and deferred rent | ||||||
1,714 | 1,711 | 2,558 | 1,389 | 219 | 1,946 | |
Operating lease liabilities | ||||||
-844 | - | - | - | - | - | |
Deferred revenue | ||||||
- | - | - | -42 | - | - | |
Deferred revenue | ||||||
- | - | - | - | -146 | -62 | |
Net cash used in operating activities | ||||||
-77,578 | -49,227 | -50,473 | -34,001 | -33,743 | - | |
Net cash used in operating activities | ||||||
- | - | - | - | - | -20,496 | |
Cash flows from investing activities: | ||||||
Purchases of property and equipment | ||||||
2,238 | 1,889 | 8,252 | 1,919 | 1,778 | 1,260 | |
Proceeds from sale of property and equipment | ||||||
- | - | 5 | 2 | 7 | - | |
Change in restricted cash | ||||||
- | - | - | - | -60 | - | |
Purchases of marketable securities | ||||||
- | - | 3,000 | 41,699 | 91,684 | 37,326 | |
Proceeds from maturities of marketable securities | ||||||
- | - | 38,200 | 80,684 | 54,826 | - | |
Net cash used in investing activities | ||||||
-2,238 | -1,889 | 26,953 | 37,068 | -38,569 | - | |
Net cash provided by investing activities | ||||||
- | - | - | - | - | -38,586 | |
Cash flows from financing activities: | ||||||
Proceeds from issuance of notes payable | ||||||
- | 12,032 | 3,700 | - | 1,897 | 14,877 | |
Proceeds from issuance of 2026 convertible notes, net of issuance costs | ||||||
37,275 | - | - | - | - | - | |
Proceeds from exercise of stock options | ||||||
78 | 397 | 685 | 199 | 207 | 35 | |
Proceeds from issuance of common stock pursuant to employee stock purchase plan | ||||||
451 | 297 | 276 | 278 | 249 | 64 | |
Proceeds from issuance of common stock upon public offering, net | ||||||
37,537 | 61,571 | 29,238 | 627 | 65,612 | 69,518 | |
Payments of offering costs | ||||||
- | - | - | - | - | 3,018 | |
Payments of insurance costs financed by a third party | ||||||
- | - | 591 | 519 | 762 | 233 | |
Repayment of notes payable | ||||||
- | 5,657 | 1,300 | - | 1,500 | 2,273 | |
Net cash provided by financing activities | ||||||
75,341 | 68,640 | 32,008 | 585 | 65,703 | - | |
Net (decrease) increase in cash, cash equivalents and restricted cash | ||||||
-4,475 | 17,524 | 8,488 | 3,652 | - | - | |
Net cash provided by (used in) financing activities | ||||||
- | - | - | - | - | 78,970 | |
Net increase in cash and cash equivalents | ||||||
- | - | - | - | -6,609 | 19,888 | |
Supplemental disclosure of cash flow information: | ||||||
Cash paid for interest | ||||||
2,298 | 1,515 | 1,461 | 1,301 | 1,251 | - | |
Cash paid for interest | ||||||
- | - | - | - | - | 844 | |
Supplemental disclosure of non-cash investing and financing activities: | ||||||
Additional right of use asset and related lease liability | ||||||
2,044 | - | - | - | - | - | |
Accretion of redeemable convertible preferred stock to redemption value | ||||||
- | - | - | - | - | 11 | |
Conversion of redeemable convertible preferred stock to common stock | ||||||
- | - | - | - | - | 74,354 | |
Conversion of warrants for redeemable convertible preferred stock to warrants for common stock | ||||||
- | - | - | - | - | 960 | |
Additions to property and equipment included in accounts payable and accrued expenses at balance sheet dates | ||||||
214 | 155 | 538 | 451 | 293 | 169 | |
Derivative liability in connection with issuance of 2026 convertible notes | ||||||
16,434 | - | - | - | - | - | |
Insurance premium financed by a third party | ||||||
- | - | - | 722 | 706 | 623 | |
Public offering costs included in accounts payable and accrued expenses at balance sheet dates | ||||||
- | 42 | 108 | - | - | - | |
Initial public offering costs included in accounts payable | ||||||
- | - | - | - | - | 95 | |