| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||||||
Net loss | ||||||||||||
-113,343 | -111,825 | -112,737 | -110,036 | -100,724 | -88,960 | -75,943 | -62,389 | -46,899 | -32,744 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||
Equity-based compensation expense | ||||||||||||
11,105 | 11,444 | 10,641 | 10,036 | 8,635 | 6,721 | 5,761 | 5,474 | 4,186 | 3,184 | 0 | 0 | 0 |
Depreciation and amortization | ||||||||||||
353 | 381 | 388 | 470 | 424 | 350 | 0 | 0 | 0 | - | - | - | - |
Non-cash contributions for expenses | ||||||||||||
- | - | - | - | - | 64 | 146 | 188 | 1,110 | 1,812 | 0 | 0 | 0 |
Depreciation | ||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | 0 |
Changes in operating assets and liabilities: | ||||||||||||
Prepaid expenses and other assets | ||||||||||||
816 | 2,936 | 1,754 | -99 | 192 | -3,751 | 1,900 | 3,580 | 3,763 | 4,956 | 0 | 0 | 0 |
Accounts payable | ||||||||||||
7,109 | 4,782 | 7,135 | 3,283 | 2,554 | 6,392 | 5,135 | 3,878 | 4,450 | 3,642 | 0 | 0 | 0 |
Accrued expenses | ||||||||||||
-1,783 | 1,516 | 2,442 | 7,807 | 7,121 | 4,155 | 6,726 | 5,090 | 4,341 | 3,184 | 0 | 0 | 0 |
Net cash used in operating activities | ||||||||||||
-97,375 | -96,638 | -93,884 | -88,341 | -81,749 | -67,094 | -59,402 | -50,831 | -36,541 | -25,858 | 0 | 0 | 0 |
Purchases of property and equipment | ||||||||||||
144 | 166 | 459 | 721 | 1,944 | 1,907 | 0 | 0 | 0 | - | - | - | - |
Net cash used in investing activities | ||||||||||||
-144 | -166 | -459 | -721 | -1,944 | -1,907 | 0 | 0 | 0 | - | - | - | - |
Proceeds from issuance of common stock, net of issuance costs | ||||||||||||
- | - | - | - | - | 9,848 | 147,321 | 221,309 | 221,295 | 221,447 | 0 | 0 | 0 |
Proceeds from issuance of common stock under employee stock plans | ||||||||||||
3,943 | 3,581 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Net cash provided by financing activities | ||||||||||||
139,039 | 138,677 | 137,620 | 118,540 | 508 | 10,197 | 147,744 | 221,410 | 221,295 | 221,447 | 0 | 0 | 0 |
Net decrease in cash and restricted cash | ||||||||||||
41,520 | 41,873 | 43,277 | 29,478 | -83,185 | -58,804 | 86,715 | 169,243 | 184,667 | 195,506 | 0 | 0 | 0 |
Supplemental disclosure of cash flow information: | ||||||||||||
Issuance costs included in accounts payable and accrued expenses | ||||||||||||
- | - | - | - | - | - | - | - | - | 571 | 0 | 0 | 0 |
Property and equipment purchases included in accounts payable and accrued expenses | ||||||||||||
-16 | 24 | -188 | -23 | 81 | 83 | 325 | 168 | 116 | 88 | 0 | 0 | 0 |
Initial recognition of right-of-use lease assets | ||||||||||||
- | 2,215 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |