| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Revenues [Abstract] | ||||||||||
Product sales, net | ||||||||||
- | - | - | - | 13,264 | 0 | 0 | - | - | - | - |
Grant revenue | ||||||||||
- | - | - | - | 245 | 539 | 1,600 | - | - | - | - |
Product sales, net | ||||||||||
111,805 | 29,868 | 64,826 | 41,617 | 13,509 | 539 | 1,600 | 6,022 | 4,524 | 2,105 | 1,444 |
Costs and expenses: | ||||||||||
Cost of product sales | ||||||||||
865 | 512 | 1,078 | 1,412 | 1,041 | 0 | 0 | - | - | - | - |
Research and development | ||||||||||
109,696 | 89,860 | 55,599 | 50,699 | 48,379 | 47,946 | 36,297 | 31,922 | 23,718 | 23,465 | 16,929 |
Selling, general and administrative | ||||||||||
64,626 | 51,718 | 52,044 | 43,782 | 35,327 | 22,601 | 15,819 | 10,985 | 8,216 | 8,746 | 5,273 |
Total costs and expenses | ||||||||||
175,187 | 142,090 | 108,721 | 95,893 | 84,747 | 70,547 | 52,116 | 42,907 | 31,934 | 32,211 | 22,202 |
Loss from operations | ||||||||||
-63,400 | -112,200 | -43,900 | -54,276 | -71,238 | -70,008 | -50,516 | -36,885 | -27,410 | -30,106 | -20,758 |
Other income | ||||||||||
- | - | - | - | 1,030 | -195 | 586 | 40 | 51 | 167 | 214 |
Litigation settlement | ||||||||||
- | - | - | - | - | - | 12,500 | 0 | 0 | - | - |
Loss on early extinguishment of debt | ||||||||||
- | -12,993 | - | -5,595 | -1,315 | 0 | 0 | - | - | -296 | - |
Interest expense | ||||||||||
22,657 | 16,252 | 11,030 | 7,819 | 3,573 | 3,470 | 2,366 | 1,729 | 1,884 | 1,535 | 2,202 |
Other income | ||||||||||
1,553 | 1,781 | 1,444 | 945 | - | - | - | 130 | 697 | 2,519 | 1,657 |
Loss before income taxes | ||||||||||
-84,486 | -139,686 | -53,481 | -66,745 | - | - | - | - | - | - | - |
Income tax benefit | ||||||||||
0 | -12,900 | 0 | 0 | - | - | - | - | - | - | - |
Net loss | ||||||||||
-84,486 | -126,757 | -53,481 | -66,745 | -75,096 | -73,673 | -39,796 | -38,444 | -28,546 | -29,251 | -21,089 |
Realized loss on sale of available-for-sale securities | ||||||||||
- | - | - | - | - | - | - | - | - | -41 | - |
Comprehensive loss | ||||||||||
-84,486 | -126,757 | -53,481 | -66,745 | -75,096 | -73,673 | -39,796 | -38,444 | -28,546 | -29,292 | - |
Basic and diluted net loss per share (USD per share) | ||||||||||
-1.71 | -2.61 | -1.17 | -1.65 | -2.00 | -2.22 | -1.39 | -1.59 | -1.29 | -1.37 | -2.92 |
Weighted-average shares used to compute basic and diluted net loss per share ( in shares) | ||||||||||
49,523 | 48,582 | 45,539 | 40,446 | 37,560 | 33,234 | 28,560 | 24,155 | 22,212 | 21,420 | 7,218 |