| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | ||
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-78,822 | -253,482 | -123,653 | -47,125 | -24,324 | ||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Non-cash income | ||||||
1,112 | 127 | 0 | 0 | - | ||
Non-cash income | ||||||
-2,490 | -531 | -530 | 181 | 617 | ||
Depreciation and amortization expense | ||||||
6,900 | 4,900 | 3,600 | 1,732 | 169 | ||
Loss on disposal of property and equipment | ||||||
-103 | -32 | -101 | 0 | 0 | ||
Acquired in-process research and development | ||||||
300 | 8,604 | 11,132 | 0 | 750 | ||
Stock-based compensation expense | ||||||
48,586 | 41,373 | 24,537 | 13,572 | 2,974 | ||
Unrealized (gain) loss on equity investments | ||||||
-5,078 | 0 | 0 | - | - | ||
Impairment of acquired in-process research and development | ||||||
0 | 15,700 | 0 | 0 | - | ||
Non-cash income tax benefit | ||||||
0 | 1,013 | 0 | 0 | - | ||
Gain from sale of priority review voucher | ||||||
110,000 | 0 | 0 | - | - | ||
Changes in operating assets and liabilities: | ||||||
Inventory | ||||||
25,637 | 0 | 0 | - | - | ||
Prepaid expenses and other assets | ||||||
35,333 | 3,157 | 264 | 1,627 | 670 | ||
Trade and other receivables | ||||||
39,501 | -8,857 | 235 | 16,700 | 144 | ||
Accounts payable and accrued expenses | ||||||
8,703 | 12,981 | 10,018 | 9,052 | 2,331 | ||
Deferred rent | ||||||
3,972 | 1,610 | 0 | 0 | 7,901 | ||
Deferred revenue | ||||||
148,031 | 2,934 | -5,182 | -6,564 | 20,781 | ||
Other liabilities | ||||||
641 | 6,827 | 0 | 0 | - | ||
Net cash used in operating activities | ||||||
-70,563 | -154,536 | -80,442 | -47,478 | 10,386 | ||
Cash flows from investing activities: | ||||||
Payment for license agreement | ||||||
2,000 | 0 | 0 | - | - | ||
Purchase of acquired in-process research and development | ||||||
300 | 8,217 | 11,132 | 0 | 0 | ||
Payment for acquisition, net of cash acquired | ||||||
0 | 0 | 5,911 | 0 | 0 | ||
Purchases of marketable securities | ||||||
530,989 | 441,486 | 279,945 | 0 | 0 | ||
Proceeds from maturities of marketable securities | ||||||
516,273 | 251,625 | 20,000 | 0 | 0 | ||
Purchases of property and equipment | ||||||
33,821 | 9,654 | 8,532 | 4,521 | 11,696 | ||
Net cash provided by investing activities | ||||||
59,163 | -207,732 | -285,520 | -4,521 | -11,696 | ||
Cash flows from financing activities: | ||||||
Proceeds from exercise of options | ||||||
15,131 | 20,733 | 2,592 | 1,116 | 0 | ||
Purchase of treasury stock | ||||||
3,435 | 673 | 0 | 552 | 0 | ||
Proceeds from issuance of Series A convertible preferred units | ||||||
- | - | - | - | 4,861 | ||
Proceeds from issuance of Series B convertible preferred stock, net | ||||||
- | - | - | - | 72,437 | ||
Financing costs | ||||||
- | - | - | - | 1,420 | ||
Proceeds from issuance of common stock under ESPP | ||||||
0 | 379,870 | 126,909 | 270,400 | 0 | ||
Proceeds from issuance of common stock under ESPP | ||||||
1,567 | 646 | 340 | 0 | 0 | ||
Proceeds from long-term debt | ||||||
50,000 | 0 | 1,550 | 0 | 0 | ||
Payments on long-term debt | ||||||
312 | 302 | 25 | 0 | 0 | ||
Net cash provided by (used in) financing activities | ||||||
62,951 | 400,274 | 131,366 | 270,963 | 75,877 | ||
Effect of exchange rate changes on cash and cash equivalents and restricted cash | ||||||
-52 | -181 | -12 | 0 | 0 | ||
Net increase in cash and cash equivalents and restricted cash | ||||||
51,499 | 37,825 | -234,608 | 218,963 | 74,566 | ||
Supplemental disclosure of cash flow information: | ||||||
Deferred financing costs included in accounts payable and accrued expenses | ||||||
- | - | - | 657 | 868 | ||
Property and equipment purchases included in accounts payable and accrued expenses | ||||||
9,518 | 2,789 | 682 | 2,683 | 1,147 | ||
One Drexel Plaza lease cost included in other liabilities | ||||||
503 | 34,986 | 0 | 0 | - | ||