| Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Sep'15 | Jun'15 | Mar'15 | Dec'14 | Sep'14 | Jun'14 | Mar'14 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||||||||||||||||
Net loss | ||||||||||||||||||||||
-66,602 | -64,230 | -54,358 | -65,257 | -47,357 | 80,165 | -46,373 | -61,821 | -65,012 | -74,360 | -52,289 | -36,837 | -32,562 | -28,676 | -25,576 | -6,154 | -16,900 | -14,336 | -9,733 | -9,015 | -6,756 | -4,168 | -4,383 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||||||||||||
Non-cash income | ||||||||||||||||||||||
- | - | - | - | - | - | - | 127 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Non-cash income | ||||||||||||||||||||||
- | - | -785 | - | - | - | -75 | -1,127 | 62 | 231 | 303 | 12 | -180 | -180 | -180 | -180 | -53 | 208 | 208 | - | - | - | - |
Depreciation and amortization expense | ||||||||||||||||||||||
2,521 | 2,587 | 2,432 | 2,080 | 1,695 | 1,618 | 1,507 | - | - | - | 1,031 | 986 | 957 | 911 | 744 | 487 | 448 | 426 | 370 | - | - | - | - |
Loss on disposal of property and equipment | ||||||||||||||||||||||
-1,626 | 0 | 0 | 20 | -64 | 0 | -59 | -32 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Acquired in-process research and development | ||||||||||||||||||||||
- | - | - | - | - | - | - | 3,397 | 1,750 | 3,070 | 387 | 11,132 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Stock-based compensation expense | ||||||||||||||||||||||
11,034 | 11,715 | 11,798 | 10,882 | 11,363 | 14,118 | 12,223 | 7,538 | 15,446 | 9,360 | 9,029 | 7,235 | 5,788 | 6,648 | 4,865 | 5,093 | 3,020 | 2,900 | 2,558 | 746 | 794 | 1,043 | 389 |
Unrealized (gain) loss on equity investments | ||||||||||||||||||||||
-13 | -422 | -211 | -9,369 | 1,672 | 2,255 | 364 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Non-cash income tax benefit | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Non-cash interest (income) expense | ||||||||||||||||||||||
-83 | -91 | -95 | - | 473 | 337 | 597 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Changes in operating assets and liabilities: | ||||||||||||||||||||||
Inventory | ||||||||||||||||||||||
922 | 837 | 4,457 | 4,899 | 8,064 | 7,114 | 5,560 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Prepaid expenses and other assets | ||||||||||||||||||||||
-673 | -32,722 | 5,334 | 29,769 | 4,305 | -268 | 1,527 | 656 | -1,167 | 1,699 | 1,969 | 1 | -338 | -260 | 860 | 992 | -214 | 335 | 514 | 87 | 266 | 159 | 156 |
Trade and other receivables | ||||||||||||||||||||||
-25,181 | 32,880 | -26,925 | 33,811 | -11,636 | 4,044 | 13,282 | - | - | - | -10,700 | 15,752 | 37 | 171 | -15,726 | 15,693 | 318 | 263 | 425 | - | - | - | - |
Accounts payable and accrued expenses | ||||||||||||||||||||||
7,696 | -186 | -3,841 | 9,580 | 7,146 | 359 | -8,382 | 12,142 | -4,003 | 7,532 | -2,690 | 5,796 | 6,208 | -839 | -1,146 | 1,397 | 4,475 | 2,308 | 870 | -0 | 419 | 1,189 | 722 |
Deferred rent | ||||||||||||||||||||||
- | - | - | - | - | - | - | -870 | 0 | -1,174 | 3,654 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Deferred revenue | ||||||||||||||||||||||
0 | 0 | -5,161 | 55,000 | -1,841 | -20,871 | 115,743 | 7,591 | -1,899 | -1,484 | -1,274 | -1,301 | -1,302 | -1,288 | -1,288 | -1,698 | -1,302 | -1,288 | -2,274 | - | - | - | - |
Other liabilities | ||||||||||||||||||||||
267 | 630 | 376 | 537 | 104 | 371 | -371 | - | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||||||||||||||||
-18,375 | -49,974 | -32,099 | -42,527 | -32,272 | -48,765 | 53,001 | -26,743 | -51,915 | -42,760 | -33,118 | -28,595 | -20,791 | -23,336 | -7,718 | -17,741 | -10,415 | -10,380 | -8,939 | 15,174 | -805 | -555 | -3,428 |
Cash flows from investing activities: | ||||||||||||||||||||||
Payment for license agreement | ||||||||||||||||||||||
0 | 0 | 0 | 0 | 0 | 0 | 2,000 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Payment for acquisition, net of cash acquired | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -0 | 0 | 3 | 5,907 | 0 | 0 | 0 | 0 | - | - | - | - |
Purchases of marketable securities | ||||||||||||||||||||||
-129 | 809 | 75,343 | 170,420 | 131,143 | 118,544 | 110,882 | - | - | - | 24,225 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Proceeds from maturities of marketable securities | ||||||||||||||||||||||
108,289 | 101,359 | 96,016 | 164,106 | 132,055 | 125,439 | 94,673 | - | - | - | 24,780 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Purchases of property and equipment | ||||||||||||||||||||||
7,444 | 5,945 | 4,288 | 18,901 | 6,791 | 3,988 | 4,141 | 759 | 1,674 | 4,991 | 2,230 | 1,065 | 1,813 | 1,178 | 4,473 | 1,444 | 565 | 826 | 1,685 | 6,733 | 4,478 | 448 | 37 |
Net cash provided by investing activities | ||||||||||||||||||||||
100,974 | 94,605 | 16,385 | -25,515 | -5,879 | 112,907 | -22,350 | -26,095 | -230,789 | 50,827 | -1,675 | -4,132 | -115,869 | -155,136 | -10,381 | -1,444 | -565 | -826 | -1,685 | -6,733 | -4,478 | -448 | -37 |
Cash flows from financing activities: | ||||||||||||||||||||||
Proceeds from exercise of options | ||||||||||||||||||||||
1,374 | 4,929 | 11,607 | 2,002 | 1,383 | 10,414 | 1,332 | 3,689 | 11,876 | 1,734 | 3,434 | 757 | 789 | 848 | 196 | 1,023 | 92 | 0 | 0 | - | - | - | - |
Purchase of treasury stock | ||||||||||||||||||||||
810 | 1,671 | 15,314 | 163 | 478 | 1,038 | 1,756 | 40 | 162 | 471 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |
Proceeds from issuance of Series A convertible preferred units | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 0 | 0 | 4,861 |
Proceeds from public offerings of common stock, net | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | -157 | 170,470 | - | - | - | - |
Proceeds from issuance of common stock under ESPP | ||||||||||||||||||||||
0 | 0 | 563 | -1,567 | 805 | 0 | 762 | -138 | 380,008 | 0 | 0 | - | - | - | -657 | - | - | - | - | - | - | - | - |
Payments on long-term debt | ||||||||||||||||||||||
1,581 | 80 | 80 | 79 | 78 | 78 | 77 | 76 | 76 | 75 | 75 | 0 | 24 | 0 | 0 | - | - | - | - | - | - | - | - |
Net cash provided by (used in) financing activities | ||||||||||||||||||||||
-1,017 | 3,178 | -3,224 | 1,760 | 51,632 | 9,298 | 261 | 3,435 | 392,292 | 1,188 | 3,359 | 1,047 | 2,249 | 128,529 | -461 | 100,557 | 92 | -157 | 170,470 | -1,147 | -565 | 72,728 | 4,861 |
Effect of exchange rate changes on cash and cash equivalents and restricted cash | ||||||||||||||||||||||
-54 | -17 | 8 | -28 | -10 | -41 | 27 | - | - | - | 6 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Net increase in cash and cash equivalents and restricted cash | ||||||||||||||||||||||
81,528 | 47,792 | -18,930 | -66,310 | 13,471 | 73,399 | 30,939 | -49,686 | 109,622 | 9,317 | -31,428 | -31,692 | -134,411 | -49,942 | -18,561 | 81,371 | -10,888 | -11,364 | 159,845 | 7,294 | -5,849 | 71,725 | 1,396 |
Supplemental disclosure of cash flow information: | ||||||||||||||||||||||
Deferred financing costs included in accounts payable and accrued expenses | ||||||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -157 | 157 | -191 | 771 | 278 | 10 |
Property and equipment purchases included in accounts payable and accrued expenses | ||||||||||||||||||||||
2,373 | -33 | 9,069 | -8,428 | 13,380 | 3,286 | 1,280 | 1,933 | -566 | -1,364 | 2,786 | 58 | -618 | 893 | 348 | 1,848 | 587 | -309 | 557 | -2,350 | 666 | 2,772 | 59 |
One Drexel Plaza lease cost included in other liabilities | ||||||||||||||||||||||
- | 0 | 0 | -574 | 355 | 359 | 363 | 34,986 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - |