| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Grant revenue | ||||||||||
2,425 | 2,521 | - | - | - | - | - | - | - | - | 14,730 |
Product sales, net | ||||||||||
- | - | - | - | - | - | - | - | - | - | 3,289 |
Collaboration revenue | ||||||||||
- | - | - | - | - | - | - | - | 8,066 | 56,786 | 11,441 |
Operating expenses: | ||||||||||
Cost of product sales | ||||||||||
- | - | - | - | - | - | - | - | - | - | 1,290 |
Research and development | ||||||||||
10,159 | 8,287 | 21,467 | 17,228 | 13,607 | 20,870 | 32,318 | 38,887 | 31,938 | 28,495 | 32,344 |
In-process research and development | ||||||||||
18,088 | - | - | - | - | - | - | - | - | - | - |
General and administrative | ||||||||||
7,286 | 1,820 | 9,188 | 8,705 | 8,234 | 9,478 | 11,281 | 10,845 | 12,027 | 13,194 | - |
Total operating expenses | ||||||||||
35,533 | 10,107 | 30,655 | 25,933 | 21,841 | 30,348 | 43,599 | 49,732 | 43,965 | 41,689 | - |
General and administrative expenses | ||||||||||
- | - | - | - | - | - | - | - | - | - | 27,778 |
Total costs and expenses | ||||||||||
- | - | - | - | - | - | - | - | - | - | 61,412 |
Loss from operations | ||||||||||
-33,108 | -7,586 | -30,655 | -25,933 | -21,841 | -30,348 | -43,599 | -49,732 | -35,899 | 15,097 | -46,682 |
Other income: | ||||||||||
Change in fair value of warrant liability | ||||||||||
1,268 | -713 | - | -8,163 | -3,081 | 8,804 | - | - | - | - | - |
Other income | ||||||||||
- | 216 | - | - | - | - | - | - | - | - | - |
Interest expense | ||||||||||
- | 1 | - | - | - | - | - | - | - | - | - |
Interest income | ||||||||||
188 | 79 | - | - | - | - | - | - | - | - | - |
Total other income | ||||||||||
-1,080 | 1,007 | 216 | 46 | 57 | -259 | 1,488 | -19 | 398 | 1,363 | 188 |
Income from discontinued operations before income taxes | ||||||||||
- | - | - | - | - | - | - | 22,676 | 2,207 | -1,166 | - |
Income tax expense | ||||||||||
- | - | - | - | - | - | - | 8,821 | 886 | - | - |
Net income from discontinued operations | ||||||||||
- | - | - | - | - | - | - | 13,855 | 1,321 | -1,166 | - |
Net loss | ||||||||||
-34,188 | -6,579 | -30,439 | -17,724 | -18,703 | -39,411 | -42,111 | -27,075 | -33,294 | 15,294 | -46,256 |
Loss from operations before income taxes | ||||||||||
- | - | - | - | - | - | - | -49,751 | -35,501 | 16,460 | -46,494 |
Income tax benefit | ||||||||||
- | - | - | - | - | - | - | -8,821 | -886 | - | -238 |
Net loss from continuing operations | ||||||||||
- | - | - | - | - | - | - | -40,930 | -34,615 | 16,460 | - |
Basic (in dollars per share) | ||||||||||
- | - | - | - | -1.33 | -4.82 | -0.67 | - | - | - | - |
Diluted (in dollars per share) | ||||||||||
- | - | - | - | -1.47 | -4.82 | -0.67 | - | - | - | - |
Net loss from continuing operations (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | -0.65 | -0.60 | 0.42 | - |
Net income from discontinued operations (in dollars per share) | ||||||||||
- | - | - | - | - | - | - | 0.22 | 0.02 | -0.03 | - |
Net loss per share, basic and diluted | ||||||||||
-3.31 | -1.83 | -1.75 | -1.22 | - | - | - | -0.43 | -0.58 | 0.39 | -1.27 |
Basic (in shares) | ||||||||||
- | - | - | - | 14,036 | 8,180 | 63,057 | - | - | - | - |
Diluted (in shares) | ||||||||||
- | - | - | - | 14,777 | 8,180 | 63,057 | - | - | - | - |
Weighted-average shares outstanding, basic and diluted | ||||||||||
10 | 3 | 17,441 | 14,559 | - | - | - | 62,809 | 57,359 | 38,874 | - |
Basic and diluted | ||||||||||
- | - | - | - | - | - | - | - | - | - | 36,415 |