| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Operating activities: | ||||||||
Net loss | ||||||||
-21,503 | -20,410 | -24,092 | -19,667 | -24,023 | -63,795 | -62,556 | -29,912 | -26,294 |
Adjustment to reconcile net loss to net cash used in operating activities: | ||||||||
Depreciation and amortization | ||||||||
14 | 55 | 88 | 96 | 150 | 434 | 446 | 319 | 316 |
Loss on asset disposal | ||||||||
- | - | - | - | -22 | - | - | -3 | - |
Amortization of deferred financing fees | ||||||||
- | - | - | - | - | - | - | 15 | 21 |
Amortization of debt discount | ||||||||
- | - | - | - | - | - | - | 8,176 | - |
Change in fair value of warrant liabilities | ||||||||
-63 | -1,597 | -1,628 | -3,988 | - | -20 | -42 | -367 | -1,287 |
Treasury note discount amortization | ||||||||
- | - | - | - | - | 6 | - | - | - |
Treasury note discount amortization | ||||||||
- | - | - | - | - | - | -4 | - | - |
Stock compensation expense | ||||||||
1,048 | 1,147 | 1,710 | 3,929 | 3,786 | 5,068 | 8,015 | 13,844 | 6 |
Gain on dissolution of GBO and other | ||||||||
- | 824 | - | - | - | - | - | - | - |
Changes in assets and liabilities: | ||||||||
Receivables | ||||||||
63 | -24 | 28 | -1,473 | 1,372 | 31 | - | - | - |
Grants receivable | ||||||||
- | - | - | - | - | - | - | -78 | -1,730 |
Prepaid expenses and other current assets | ||||||||
-110 | -60 | -768 | -244 | -1,234 | -1,220 | 2,662 | 1,098 | -253 |
Other assets | ||||||||
1 | 137 | - | - | - | - | - | - | - |
Restricted cash | ||||||||
- | - | - | - | -75 | - | - | - | - |
Other assets | ||||||||
- | - | - | - | - | - | - | 15 | - |
Accounts payable | ||||||||
232 | -1,454 | 863 | 1,902 | -606 | 317 | -1,807 | -97 | 2,230 |
Accrued expenses and other current liabilities | ||||||||
-378 | 838 | -1,047 | 653 | -2,048 | -43 | - | - | - |
Deferred revenue | ||||||||
-227 | -398 | -454 | - | - | - | - | - | - |
Other liabilities | ||||||||
- | - | - | - | -1 | -5 | - | - | - |
Accrued expenses | ||||||||
- | - | - | - | - | - | 1,894 | 2,573 | 1,123 |
Other liabilities | ||||||||
- | - | - | - | - | - | -37 | -41 | 58 |
Deferred revenue | ||||||||
- | - | - | -455 | -8,455 | -787 | -4,631 | 8,155 | 7,673 |
Net cash used in operating activities | ||||||||
-20,831 | -22,696 | -23,820 | -15,813 | - | - | - | - | - |
Investing activities: | ||||||||
Net cash used in operating activities | ||||||||
- | - | - | - | -31,238 | -57,648 | -61,384 | 1,633 | -14,171 |
Payments for purchase of property and equipment | ||||||||
55 | - | - | - | - | 228 | 609 | 279 | 256 |
Net cash used in investing activities | ||||||||
-55 | - | - | - | - | - | - | - | - |
Financing activities: | ||||||||
Proceeds from the sale of common stock and warrants, net of costs | ||||||||
21,759 | 35,068 | - | - | - | - | - | - | - |
Security deposits | ||||||||
- | - | - | - | - | - | - | - | 15 |
Purchases of marketable securities | ||||||||
- | - | - | - | - | - | 39,990 | - | - |
Maturities of marketable securities | ||||||||
- | - | - | - | - | 40,000 | - | - | - |
Net cash provided by investing activities | ||||||||
- | - | - | - | - | 39,772 | -40,599 | -279 | -241 |
Proceeds from the sale of common stock and warrants, net of costs | ||||||||
- | - | 6,360 | 17,420 | 7,464 | - | - | - | - |
Effect of foreign currency translation on cash | ||||||||
- | - | - | -9 | - | - | - | - | - |
Contribution from non-controlling interest | ||||||||
- | - | - | - | - | 500 | 500 | - | - |
Reverse stock split cash paid in lieu of fractional shares | ||||||||
- | - | - | - | - | - | 4 | - | - |
Proceeds from stockholder in connection with settlement of stock option exercises | ||||||||
- | - | - | - | - | - | - | 3,943 | - |
Settlement of stock options | ||||||||
- | - | - | - | - | - | - | 2,835 | - |
Proceeds from the exercise of warrants | ||||||||
4,900 | - | - | - | - | - | - | 2,167 | 1,918 |
Proceeds from the exercise of pre-funded warrants | ||||||||
35 | - | - | - | - | - | - | - | - |
Proceeds from initial public offering of common stock, net of issuance costs | ||||||||
- | - | - | - | - | - | 79,811 | - | - |
Proceeds from the exercise of stock options | ||||||||
- | 589 | - | 3 | - | 963 | 157 | 165 | 154 |
Net cash provided by financing activities | ||||||||
26,648 | 35,657 | 6,360 | 17,423 | - | - | - | - | - |
Effect of foreign currency translation on cash | ||||||||
-6 | -15 | 34 | - | - | - | - | - | - |
Net increase (decrease) in cash and cash equivalents | ||||||||
5,756 | 12,946 | -17,426 | - | - | - | - | - | - |
Repayments of long-term debt | ||||||||
- | - | - | - | - | - | - | - | 917 |
Release of cash restricted for debt repayment | ||||||||
- | - | - | - | - | - | - | - | 792 |
Proceeds from stockholder loan and convertible debt | ||||||||
- | - | - | - | - | - | - | 25,824 | 620 |
Net cash provided by financing activities | ||||||||
- | - | - | - | 7,464 | 1,463 | 80,464 | 77,460 | 9,785 |
Effect of foreign currency translation on cash | ||||||||
- | - | - | - | -9 | -14 | 1 | - | - |
Net (decrease) increase in cash and cash equivalents | ||||||||
- | - | - | 1,601 | -23,783 | -16,427 | - | - | - |
Net decrease in cash and cash equivalents | ||||||||
- | - | - | - | - | - | -21,518 | 78,814 | -4,627 |
Income taxes paid | ||||||||
- | - | - | - | - | - | 435 | - | - |