| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | ||
|---|---|---|---|---|---|---|
Operating activities: | ||||||
Net loss | ||||||
-110,053 | -106,658 | -48,902 | 22,613 | -28,314 | ||
Adjustments to reconcile net loss to cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
1,108 | 539 | 166 | 83 | 75 | ||
Stock-based compensation | ||||||
9,860 | 8,543 | 5,096 | 599 | 588 | ||
Amortization of debt discount and issuance costs | ||||||
658 | 404 | 198 | 776 | 195 | ||
Loss on extinguishment of debt | ||||||
-7,155 | 0 | - | - | - | ||
Loss on sale of equipment | ||||||
- | - | - | 0 | 0 | ||
Changes in operating assets and liabilities: | ||||||
Accounts receivable | ||||||
11,333 | 2,310 | 0 | - | - | ||
Grants and other receivables | ||||||
-68 | 196 | -337 | -65 | -144 | ||
Prepaid expenses and other assets | ||||||
26 | 762 | -2,358 | 3,888 | -1,504 | ||
Inventory | ||||||
-3,759 | 4,698 | 2,013 | 0 | 0 | ||
Accounts payable | ||||||
-3,856 | 3,171 | 392 | -130 | 450 | ||
Accrued expenses and other liabilities | ||||||
11,845 | 10,150 | 6,688 | -1,097 | -3,814 | ||
Accrued interest | ||||||
- | - | - | 2,740 | 669 | ||
Deferred other income | ||||||
- | - | - | -41 | -211 | ||
Cash used in operating activities | ||||||
-90,815 | -91,817 | -35,680 | 21,720 | -28,714 | ||
Investing activities: | ||||||
Purchases of property and equipment | ||||||
557 | 1,690 | 2,406 | 215 | 80 | ||
Cash used in investing activities | ||||||
-557 | -1,690 | -2,406 | -215 | -80 | ||
Financing activities: | ||||||
Proceeds from the sale of common stock units in connection with initial public offering | ||||||
- | - | - | 0 | 0 | ||
Proceeds from issuance of convertible notes payable, net | ||||||
- | - | - | 0 | 14,285 | ||
Proceeds from long-term debt | ||||||
1,008 | 739 | 75,000 | 0 | 0 | ||
Cash paid for financing costs | ||||||
5,776 | 6,547 | 13,433 | 0 | 162 | ||
Proceeds from the sale of common stock | ||||||
41,438 | 63,969 | 36,712 | - | - | ||
Proceeds from long-term debt | ||||||
77,596 | 0 | 138,000 | - | - | ||
Proceeds from issuance of common stock under employee stock purchase plan | ||||||
2,404 | 0 | 0 | - | - | ||
Proceeds from the exercise of stock options | ||||||
1,038 | 1,488 | 134 | 55 | 0 | ||
Payment of withholdings on shares withheld for income taxes | ||||||
0 | 70 | 288 | 0 | 0 | ||
Repayment of Athyrium debt facility | ||||||
80,179 | 0 | - | - | - | ||
Cash provided by financing activities | ||||||
37,529 | 59,579 | 236,125 | 55 | 19,123 | ||
Effects of exchange rate changes on cash and cash equivalents | ||||||
-3 | 64 | - | - | - | ||
Effects of exchange rate changes on cash and cash equivalents | ||||||
- | - | -11 | 39 | -14 | ||
Net decrease in cash, cash equivalents and restricted cash | ||||||
-53,846 | -33,864 | - | - | - | ||
Net (decrease) increase in cash and cash equivalents | ||||||
- | - | 198,028 | 21,599 | -9,685 | ||
Supplemental disclosure of noncash activities: | ||||||
Cash paid for interest | ||||||
8,785 | 8,253 | 0 | - | - | ||
Supplemental disclosure of noncash activities: | ||||||
Fixed asset purchases within accounts payable and accrued expenses | ||||||
38 | 146 | - | - | - | ||
Fixed asset additions acquired through tenant allowance | ||||||
0 | 361 | - | - | - | ||
Fixed asset purchases within accounts payable and accrued expenses | ||||||
483 | 0 | 0 | 0 | 0 | ||
Recognition of initial right-of-use assets | ||||||
2,483 | 0 | 0 | - | - | ||
Recognition of initial lease liabilities | ||||||
2,959 | 0 | 2,454 | - | - | ||
Conversion of convertible notes payable and accrued interest into Series C-2 preferred stock | ||||||
- | - | 237,259 | 0 | 0 | ||
Redeemable Convertible Preferred Stock, Series C, C1, C2, and D | ||||||
Deemed dividend | ||||||
- | - | 11,969 | - | - | ||
Redeemable Convertible Preferred Stock, Series C, C1, D | ||||||
Deemed dividend | ||||||
- | - | 1,096 | - | - | ||
Redeemable Convertible Preferred Stock, Series C2 | ||||||
Conversion of convertible notes payable and accrued interest into Series C-2 preferred stock | ||||||
- | - | 19,527 | - | - | ||