| Dec'19 | Dec'18 | Dec'17 | ||||
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss attributable to ordinary shareholders | ||||||
-163,422 | -230,495 | -39,744 | ||||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation | ||||||
1,675 | 1,199 | 302 | ||||
Non-cash share-based compensation | ||||||
19,424 | 6,766 | 1,019 | ||||
Non-cash interest expense | ||||||
311 | - | - | ||||
Amortization of provision on loss contract | ||||||
-3,855 | -6,300 | - | ||||
Non-cash consideration for licenses and milestones | ||||||
- | 94,776 | 3,126 | ||||
Amortization of (discount) premium on marketable securities | ||||||
-676 | - | - | ||||
Unrealized foreign currency gains | ||||||
1,859 | - | - | ||||
Changes in operating assets and liabilities: | ||||||
Trade receivables | ||||||
-715 | 927 | - | ||||
Research and development tax credit receivable | ||||||
17,564 | 10,079 | 152 | ||||
Prepaid expenses, other current assets and other assets | ||||||
5,151 | 5,867 | 3,753 | ||||
Operating leases, right-of-use assets | ||||||
3,064 | - | - | ||||
Accounts payable | ||||||
-6,413 | 14,848 | 1,930 | ||||
Accrued expenses and other current liabilities | ||||||
11,434 | 31,663 | 4,672 | ||||
Other long-term liabilities | ||||||
-1,424 | 6,880 | 113 | ||||
Operating lease liabilities | ||||||
-2,390 | - | - | ||||
Net cash used in operating activities | ||||||
-166,131 | -97,536 | -32,487 | ||||
Cash flows from investing activities: | ||||||
Proceeds from sales and maturities of marketable securities | ||||||
109,019 | - | - | ||||
Purchases of marketable securities | ||||||
414,010 | - | - | ||||
Purchases of property and equipment | ||||||
4,367 | 4,032 | 1,559 | ||||
Net cash provided by (used in) investing activities | ||||||
-309,358 | -4,032 | -1,559 | ||||
Cash flows from financing activities: | ||||||
Issuance of debt from credit facility, net of issuance costs | ||||||
24,466 | - | - | ||||
Issuance of convertible preferred shares, net of issuance costs | ||||||
- | 149,367 | 115,696 | ||||
Issuance of ADRs in public offerings | ||||||
130,270 | 209,669 | - | ||||
Payment of offering costs | ||||||
605 | 4,200 | - | ||||
Proceeds from employee equity plans | ||||||
3,322 | 28 | - | ||||
Net cash provided by financing activities | ||||||
157,453 | 354,864 | 115,696 | ||||
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | ||||||
1,672 | -3,471 | 4,709 | ||||
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||
-316,364 | 249,825 | 86,359 | ||||
Supplemental disclosure of non-cash investing and financing activities | ||||||
Settlement of tranche obligations | ||||||
- | - | 1,402 | ||||
Property and equipment included in accounts payable and accrued expenses | ||||||
647 | - | 1,247 | ||||
Convertible preferred shares issued for licenses | ||||||
- | 93,391 | - | ||||
Supplemental disclosure of cash flow information: | ||||||
Cash paid for interest | ||||||
1,227 | - | - | ||||
Cash paid for taxes | ||||||
1,474 | - | - | ||||