Cash flows from operating activities:

Net loss attributable to ordinary shareholders

Adjustments to reconcile net loss to net cash used in operating activities:

Depreciation

Non-cash share-based compensation

Amortization of Strimvelis loss provision

Other non-cash adjustments

Changes in operating assets and liabilities:

Trade receivables

Research and development tax credit receivable

Prepaid expenses, other current assets and other assets

Operating leases, right-of-use assets

Accounts payable, accrued expenses and other current liabilities

Other long-term liabilities

Operating lease liabilities

Net cash used in operating activities

Cash flows from investing activities:

Proceeds from sales and maturities of marketable securities

Payment of construction deposit

Purchases of property and equipment

Net cash provided by (used in) investing activities

Cash flows from financing activities:

Proceeds from exercise of share options

Net cash provided by financing activities

Effect of exchange rate changes on cash, cash equivalents, and restricted cash

Net increase (decrease) in cash, cash equivalents and restricted cash

Supplemental disclosure of non-cash investing and financing activities

Property and equipment included in accounts payable and accrued expenses

Lease assets obtained in exchange for new operating lease liabilities

Supplemental disclosure of cash flow information:

Cash paid for interest