| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenues | |||||||||||||||||||
- | - | 5,853 | 583 | 641 | 1,067 | 771 | 771 | 771 | 771 | 2,902 | 303 | 303 | 303 | 494 | 494 | 994 | 994 | 1,294 | 494 |
Operating expenses: | |||||||||||||||||||
Research and development | |||||||||||||||||||
4,383 | 5,847 | 7,404 | 4,393 | 5,935 | 6,071 | 7,149 | 5,795 | 5,156 | 402 | 2,307 | 4,157 | 4,116 | 13,227 | 3,873 | 12,017 | 4,138 | 12,733 | 9,681 | 10,154 |
General and administrative | |||||||||||||||||||
1,957 | 2,336 | 2,782 | 1,834 | 1,849 | 2,903 | 6,036 | 2,195 | 2,446 | 3,549 | 3,505 | 3,481 | 4,024 | 4,870 | 6,574 | 10,504 | -189 | 4,674 | 2,659 | 4,342 |
Impairment of property and equipment | |||||||||||||||||||
423 | - | - | - | 561 | 2,349 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Total operating expenses | |||||||||||||||||||
6,763 | 8,184 | 18,545 | 6,228 | 8,346 | 11,324 | 13,185 | 7,991 | 7,602 | 3,951 | 5,812 | 7,639 | 8,141 | 18,098 | 10,447 | 22,522 | 3,948 | 17,408 | 12,340 | 14,496 |
Loss from operations | |||||||||||||||||||
-6,763 | -8,184 | -12,691 | -5,644 | -7,705 | -10,257 | -12,413 | -7,219 | -6,831 | -3,179 | -2,910 | -7,336 | -7,837 | -17,795 | -9,952 | -22,027 | -2,953 | -16,413 | -11,045 | -14,001 |
Interest expense, net | |||||||||||||||||||
696 | 597 | 210 | 1,081 | 1,053 | 1,120 | 1,105 | 1,147 | 920 | 717 | 2,147 | 1,745 | 1,243 | 489 | 615 | 299 | 537 | 398 | 554 | 705 |
Loss on extinguishment of debt | |||||||||||||||||||
0 | -8,060 | - | -423 | -183 | - | 0 | 0 | 0 | -1,252 | - | - | - | - | - | - | - | - | - | - |
Change in fair value of redemption feature | |||||||||||||||||||
-1,759 | -37 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Change in fair value of warrant liability | |||||||||||||||||||
-0 | -201 | -172 | -1,931 | 1,301 | -1,636 | -821 | 64 | -211 | -78 | 817 | -3,750 | -1,035 | 810 | - | 0 | - | - | - | - |
Loss before income taxes | |||||||||||||||||||
- | - | - | -5,218 | - | - | -12,697 | -8,431 | -7,539 | -5,071 | -5,875 | -5,331 | -8,045 | -19,094 | -10,567 | -22,326 | -3,491 | -16,812 | -11,600 | -14,707 |
Income tax benefit | |||||||||||||||||||
- | - | - | -777 | - | - | -497 | 0 | 0 | -3,150 | 497 | 0 | 0 | 4 | 0 | 0 | 50 | 52 | 120 | -726 |
Net loss | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -11,720 | - |
Less: Net loss attributable to noncontrolling interests | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | -380 | - |
Net loss | |||||||||||||||||||
-5,700 | -16,602 | -10,096 | -4,440 | -10,244 | -9,741 | -12,199 | -8,431 | -7,539 | -1,920 | -6,373 | -5,331 | -8,045 | -19,098 | -10,567 | -22,327 | -3,542 | -16,864 | -11,340 | -13,981 |
Beneficial conversion feature upon issuance of Series A-1 convertible preferred stock | |||||||||||||||||||
- | - | - | - | 61 | - | 286 | 0 | 381 | 15,355 | - | - | - | - | - | - | - | - | - | - |
Series A-1 convertible preferred stock dividends and related settlement | |||||||||||||||||||
0 | 166 | 162 | 158 | 154 | 150 | 163 | 652 | 636 | 450 | - | - | - | - | - | - | - | - | - | - |
Deemed dividend upon modification of warrants | |||||||||||||||||||
1,431 | 1,708 | - | - | 829 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Deemed dividend upon amendment of the terms of the Series A-1 convertible preferred stock | |||||||||||||||||||
10,328 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Accretion of redeemable preferred stock and noncontrolling interests | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | 493 | 1,030 | 939 | 1,091 | 1,034 |
Deemed dividends upon the repurchase of Series A redeemable preferred stock and redeemable noncontrolling interests | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 67 |
Deemed dividend upon issuance of warrants to common stockholders | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 7,373 | - | - | - | - |
Net loss attributable to common stockholders | |||||||||||||||||||
-17,459 | -18,477 | -10,258 | -4,599 | -11,289 | -9,892 | -12,649 | -9,084 | -8,558 | -17,726 | -7,550 | -5,331 | -8,045 | -19,098 | -10,567 | -30,194 | -4,572 | -17,803 | -12,431 | -15,083 |
Per share information: | |||||||||||||||||||
Net loss per share of common stock, basic (in dollars per share) | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -0.22 | -0.34 | - | - | -1.60 | -0.32 | - | - | - |
Net loss per share of common stock, diluted (in dollars per share) | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -0.22 | -0.38 | - | - | -1.60 | -0.32 | - | - | - |
Weighted average shares outstanding, basic (in shares) | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 24,442 | 23,723 | - | - | 18,816 | 14,155 | - | - | - |
Weighted average shares outstanding, diluted (in shares) | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 24,442 | 23,801 | - | - | 18,816 | 14,155 | - | - | - |
Net loss per share of common stock, basic and diluted (in dollars per share) | |||||||||||||||||||
-0.36 | -0.62 | 0.20 | -0.20 | -0.98 | -1.00 | -4.27 | -2.10 | -2.66 | -0.71 | - | - | - | -0.82 | - | - | - | -1.36 | -1.30 | -1.61 |
Weighted average shares outstanding, basic and diluted (in shares) | |||||||||||||||||||
47,895 | 29,901 | 28,387 | 23,007 | 11,529 | 9,843 | -12,808 | 4,317 | 3,216 | 25,003 | - | - | - | 23,196 | - | - | - | 13,061 | 9,588 | 9,377 |