| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 | Dec'15 | Jun'15 | Mar'15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Collaboration revenues | |||||||||||||||||||
- | - | 8,146 | 3,064 | 3,252 | 3,383 | 3,087 | 5,217 | 4,749 | 4,280 | 3,811 | 1,404 | 1,596 | 2,287 | 2,979 | 0 | 3,779 | 0 | 0 | 0 |
Operating expenses: | |||||||||||||||||||
Research and development | |||||||||||||||||||
22,028 | 23,581 | 23,805 | 23,550 | 24,952 | 24,173 | 18,504 | 13,662 | 12,023 | 10,984 | 23,809 | 25,375 | 33,235 | 33,256 | 32,763 | 0 | 36,707 | 0 | 0 | 0 |
General and administrative | |||||||||||||||||||
8,910 | 8,802 | 9,369 | 12,623 | 12,985 | 13,582 | 14,227 | 11,696 | 12,982 | 14,560 | 15,882 | 18,950 | 25,973 | 21,760 | 21,563 | 0 | 11,486 | 0 | 0 | 0 |
Impairment of property and equipment | |||||||||||||||||||
0 | - | - | - | 0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Total operating expenses | |||||||||||||||||||
39,721 | 41,304 | 44,445 | 39,085 | 40,849 | 40,105 | 32,731 | 25,359 | 25,006 | 25,545 | 39,691 | 44,326 | 59,209 | 55,017 | 54,326 | 0 | 48,194 | 0 | 0 | 0 |
Loss from operations | |||||||||||||||||||
-33,283 | -34,225 | -36,299 | -36,020 | -37,596 | -36,721 | -29,644 | -20,141 | -20,257 | -21,264 | -35,880 | -42,922 | -57,613 | -52,729 | -51,347 | 0 | -44,414 | 0 | 0 | 0 |
Interest expense, net | |||||||||||||||||||
2,585 | 2,943 | 3,466 | 4,361 | 4,427 | 4,294 | 3,891 | 4,933 | 5,531 | 5,854 | 5,625 | 4,094 | 2,647 | 1,941 | 1,851 | 0 | 2,197 | 0 | 0 | 0 |
Loss on extinguishment of debt | |||||||||||||||||||
-8,667 | 0 | - | 0 | 0 | - | -1,252 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - |
Change in fair value of redemption feature | |||||||||||||||||||
0 | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Change in fair value of warrant liability | |||||||||||||||||||
-2,305 | -1,003 | -2,438 | -3,087 | -1,091 | -2,605 | -1,047 | 591 | -3,223 | -4,047 | -3,158 | 0 | 0 | 0 | - | 0 | - | - | - | - |
Loss before income taxes | |||||||||||||||||||
- | - | - | -37,902 | - | - | -33,740 | -26,918 | -23,818 | -24,324 | -38,347 | -43,039 | -60,035 | -55,481 | -53,198 | 0 | -46,612 | 0 | 0 | 0 |
Income tax benefit | |||||||||||||||||||
- | - | - | 0 | - | - | -3,648 | -2,653 | -2,653 | -2,653 | 501 | 4 | 4 | 55 | 103 | 0 | -503 | 0 | 0 | 0 |
Net loss | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - |
Less: Net loss attributable to noncontrolling interests | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - |
Net loss | |||||||||||||||||||
-36,840 | -41,384 | -34,523 | -36,627 | -40,618 | -37,913 | -30,091 | -24,265 | -21,165 | -21,671 | -38,849 | -43,043 | -60,039 | -55,536 | -53,301 | 0 | -45,728 | 0 | 0 | 0 |
Beneficial conversion feature upon issuance of Series A-1 convertible preferred stock | |||||||||||||||||||
- | - | - | - | 0 | - | 16,022 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - |
Series A-1 convertible preferred stock dividends and related settlement | |||||||||||||||||||
486 | 640 | 624 | 626 | 1,121 | 1,603 | 1,903 | 0 | 0 | 0 | - | - | - | - | - | - | - | - | - | - |
Deemed dividend upon modification of warrants | |||||||||||||||||||
0 | 0 | - | - | 0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Deemed dividend upon amendment of the terms of the Series A-1 convertible preferred stock | |||||||||||||||||||
0 | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - |
Accretion of redeemable preferred stock and noncontrolling interests | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | 2,463 | 0 | 4,096 | 0 | 0 | 0 |
Deemed dividends upon the repurchase of Series A redeemable preferred stock and redeemable noncontrolling interests | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 |
Deemed dividend upon issuance of warrants to common stockholders | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | - | - | - | - | 0 | - | - | - | - |
Net loss attributable to common stockholders | |||||||||||||||||||
-50,794 | -44,625 | -36,039 | -38,431 | -42,916 | -40,184 | -48,018 | -42,919 | -39,165 | -38,653 | -40,025 | -43,043 | -67,906 | -64,433 | -63,138 | 0 | -49,891 | 0 | 0 | 0 |
Per share information: | |||||||||||||||||||
Net loss per share of common stock, basic (in dollars per share) | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -0.22 | -0.34 | - | - | -1.60 | -0.32 | - | - | - |
Net loss per share of common stock, diluted (in dollars per share) | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | -0.22 | -0.38 | - | - | -1.60 | -0.32 | - | - | - |
Weighted average shares outstanding, basic (in shares) | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 24,442 | 23,723 | - | - | 18,816 | 14,155 | - | - | - |
Weighted average shares outstanding, diluted (in shares) | |||||||||||||||||||
- | - | - | - | - | - | - | - | - | - | - | 24,442 | 23,801 | - | - | 18,816 | 14,155 | - | - | - |
Net loss per share of common stock, basic and diluted (in dollars per share) | |||||||||||||||||||
-0.36 | -0.62 | 0.20 | -0.20 | -0.98 | -1.00 | -4.27 | -2.10 | -2.66 | -0.71 | - | - | - | -0.82 | - | - | - | -1.36 | -1.30 | -1.61 |
Weighted average shares outstanding, basic and diluted (in shares) | |||||||||||||||||||
47,895 | 29,901 | 28,387 | 23,007 | 11,529 | 9,843 | -12,808 | 4,317 | 3,216 | 25,003 | - | - | - | 23,196 | - | - | - | 13,061 | 9,588 | 9,377 |