| Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 |
|---|---|---|---|---|---|---|
Revenues | ||||||
Total revenues | ||||||
35,412 | 25,573 | 38,551 | - | - | - | - |
Licensing and collaboration revenue | ||||||
- | - | - | - | 500 | 15 | - |
Product sales | ||||||
- | - | - | 678 | 267 | 108 | - |
Total revenues | ||||||
- | - | - | 678 | 767 | 123 | - |
Costs and expenses | ||||||
Cost of product sales | ||||||
6,783 | 16,387 | 3,139 | - | - | - | - |
Cost of product sales | ||||||
- | - | - | 365 | 333 | 108 | - |
Royalty expense | ||||||
3,865 | 1,821 | 106 | 84 | 72 | 1 | - |
Research and development | ||||||
6,855 | 15,126 | 30,462 | 24,964 | 19,985 | 10,925 | 7,291 |
Selling, general and administrative | ||||||
28,780 | 28,897 | 27,342 | 19,819 | 17,938 | 8,572 | - |
General and administrative | ||||||
- | - | - | - | - | - | 2,987 |
In-process research and development | ||||||
- | - | - | - | 2,157 | 0 | 1,500 |
Amortization of intangible assets | ||||||
517 | 350 | 379 | 1,544 | 1,891 | 298 | 0 |
Impairment of intangible assets | ||||||
- | 7,448 | 7,942 | 43,398 | - | - | - |
In-process research and development | ||||||
500 | - | - | - | - | - | - |
Total costs and expenses | ||||||
47,300 | 70,029 | 69,370 | 90,174 | 42,376 | 19,904 | 11,778 |
Loss from operations | ||||||
-11,888 | -44,456 | -30,819 | -89,496 | -41,609 | -19,781 | -11,778 |
Other income (expense) | ||||||
Interest income | ||||||
666 | 449 | 385 | 189 | 123 | 75 | 21 |
Interest expense | ||||||
3,391 | 3,481 | 3,396 | 1,585 | 1,060 | 432 | - |
Other income (expense), net | ||||||
-109 | -22 | 255 | 5,140 | 2,287 | 478 | - |
Other income | ||||||
- | - | - | - | - | - | 121 |
Total other income (expense) | ||||||
-2,834 | -3,054 | -2,756 | 3,744 | 1,350 | 121 | 142 |
Loss before income taxes | ||||||
- | - | - | -85,752 | -40,259 | -19,660 | -11,636 |
Income tax benefit | ||||||
- | - | - | -1,698 | -1,443 | -12,722 | - |
Net loss | ||||||
-14,722 | -47,510 | -33,575 | -84,054 | -38,816 | -6,938 | -11,636 |
Net loss per share, basic and diluted | ||||||
-0.32 | -1.17 | -0.95 | -2.45 | -1.30 | -0.63 | -34.53 |
Unaccreted dividends on convertible preferred stock | ||||||
- | - | - | - | - | - | -2,035 |
Net income (loss) attributable to common stockholders | ||||||
- | - | - | - | - | - | -13,671 |
Weighted average shares outstanding, basic and diluted | ||||||
46,606 | 40,494 | 35,273 | 34,355 | 29,767 | 11,059 | 395 |
Licensing and Collaboration [Member] | ||||||
Total revenues | ||||||
23,326 | 5,913 | 38,233 | - | - | - | - |
Product Sales [Member] | ||||||
Total revenues | ||||||
12,086 | 19,660 | 318 | - | - | - | - |