| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 |
|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||||||
Net loss | ||||||||||
-68,552 | -67,657 | -51,013 | 10,733 | -39,119 | 4,410 | -42,572 | -35,431 | 10,381 | -69,725 | -30,612 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||
Write-off of fixed assets | ||||||||||
- | - | - | - | - | - | - | - | - | - | 334 |
Amortization of discounts, net of premiums, on marketable securities | ||||||||||
- | - | - | - | - | - | - | - | - | - | -889 |
Stock-based compensation expense | ||||||||||
4,392 | 5,209 | 4,142 | 2,457 | 2,948 | 3,523 | 3,546 | 6,536 | 6,362 | 9,515 | 12,986 |
Depreciation and amortization | ||||||||||
2,366 | 1,497 | 1,121 | 2,078 | 565 | 545 | 939 | 1,324 | 2,066 | 2,853 | 5,078 |
Gain on sale of fixed assets | ||||||||||
- | - | - | - | 2 | 110 | -204 | 327 | 0 | 0 | - |
Paid in-kind interest | ||||||||||
- | - | - | 765 | 0 | 0 | - | - | - | - | - |
Non-cash interest expense | ||||||||||
271 | 302 | 247 | 38 | 0 | 0 | - | - | - | - | - |
Deferred income tax | ||||||||||
6 | -1,548 | -11,435 | 1,811 | -133 | -989 | -362 | 0 | 0 | - | - |
Other | ||||||||||
-11 | - | 3 | 296 | - | - | - | - | - | - | - |
Intangible impairment charge | ||||||||||
- | 23,200 | - | - | - | 2,676 | 919 | 0 | 0 | - | - |
Change in fair value of contingent consideration liability | ||||||||||
916 | -5,800 | 2,600 | -4,600 | 1,600 | 1,500 | -200 | 0 | 0 | - | - |
Acqusition of subsidiary escrow shares returned | ||||||||||
- | - | - | - | - | 82 | 0 | 0 | - | - | - |
Gain on sale of marketable securities | ||||||||||
- | - | - | - | - | - | - | - | - | - | 237 |
Changes in assets and liabilities: | ||||||||||
Accounts receivable | ||||||||||
12,176 | -204 | -892 | 1,322 | 3,415 | -2,770 | -4,114 | 5,421 | -767 | -5,239 | 6,185 |
Other current assets | ||||||||||
2,898 | 403 | -2,046 | - | - | - | - | - | - | - | - |
Other current assets | ||||||||||
- | - | - | -1,314 | 3,058 | 572 | -336 | 754 | -882 | 333 | -2,063 |
Other assets | ||||||||||
- | - | - | 469 | 1,535 | 0 | -2,044 | 2,002 | -1,050 | -617 | 1,667 |
Other assets | ||||||||||
2,035 | 150 | -468 | - | - | - | - | - | - | - | - |
Accounts payable | ||||||||||
808 | -2,906 | 2,779 | 243 | -202 | -435 | - | - | - | - | - |
(Decrease) increase in deferred revenue - long term | ||||||||||
- | - | - | - | - | - | - | - | - | - | 0 |
Accrued expenses | ||||||||||
2,612 | 1,009 | -6,274 | 6,581 | 2,354 | 493 | - | - | - | - | -266 |
Increase (decrease) in accounts payable and accrued expenses | ||||||||||
- | - | - | - | - | - | -1,956 | -691 | -3,352 | 3,847 | -660 |
(Decrease) in deferred revenue - current | ||||||||||
- | - | - | - | - | - | -886 | 634 | 204 | 0 | - |
Other current liabilities | ||||||||||
80 | - | - | -158 | -60 | 0 | -2,069 | 2,069 | 3 | -58 | 113 |
(Decrease) in deferred revenue - long term | ||||||||||
- | - | - | - | - | - | - | -162 | 162 | 0 | -31,645 |
Other liabilities | ||||||||||
-499 | 291 | 323 | 343 | -80 | -3 | -164 | -419 | -138 | 1,635 | - |
Net cash used in operating activities | ||||||||||
-74,698 | -46,752 | -54,107 | 19,518 | -40,137 | 13,726 | -36,107 | -34,644 | 18,387 | -46,410 | -49,809 |
Cash flows from investing activities: | ||||||||||
Acquisition of AZEDRA manufacturing assets | ||||||||||
8,000 | - | - | - | - | - | - | - | - | - | - |
Acquisition of subsidiary, net of cash acquired | ||||||||||
- | - | - | - | 6,202 | 0 | 0 | - | - | - | - |
Cash acquired in acquisition of subsidiary | ||||||||||
- | - | - | - | - | - | 1,888 | 0 | 0 | - | - |
Purchases of property and equipment | ||||||||||
7,231 | 817 | 269 | 4,286 | 370 | 714 | 137 | 767 | 226 | 2,171 | 901 |
Portion of MIP milestones paid to former advisor | ||||||||||
277 | - | - | - | - | - | - | - | - | - | - |
Proceeds from sale of fixed assets | ||||||||||
- | - | 37 | 347 | 48 | 143 | 174 | 390 | 0 | 0 | -320 |
Net cash used in investing activities | ||||||||||
-15,508 | -817 | -232 | -3,939 | -6,524 | 1,829 | 3,025 | -277 | 74 | -471 | 79,652 |
Cash flows from financing activities: | ||||||||||
Net proceeds common stock | ||||||||||
- | - | - | - | 0 | 37,459 | 40,078 | 23,348 | 0 | 0 | - |
Repayment of debt | ||||||||||
5,843 | 5,390 | - | - | - | - | - | - | - | - | - |
Net proceeds from issuance of long-term debt | ||||||||||
- | - | - | 48,650 | 0 | 0 | - | - | - | - | - |
Equity issuance costs in connection with acquisition of subsidiary | ||||||||||
- | - | - | - | - | - | -45 | 0 | 0 | - | - |
Proceeds from exercise of stock options | ||||||||||
1,942 | 467 | 469 | 1,340 | 1,737 | 428 | 71 | 306 | 3,726 | 3,896 | 4,874 |
Proceeds from redemption of auction rate securities | ||||||||||
- | - | - | - | - | 2,400 | 1,100 | 100 | 300 | 1,700 | 80,233 |
Return of estimated interest payment for noncontrolling interest | ||||||||||
- | - | 15 | -368 | -292 | - | - | - | - | - | - |
Purchase of noncontrolling interests | ||||||||||
- | - | - | - | - | 0 | 0 | - | - | - | - |
Net cash used in financing activities | ||||||||||
-3,901 | 94,717 | 5,510 | 49,622 | 1,445 | 37,887 | 40,104 | 23,654 | 3,726 | 3,896 | 4,874 |
Effect of currency rate changes on cash, cash equivalents and restricted cash | ||||||||||
-48 | -92 | 83 | -86 | 17 | 0 | 0 | - | - | - | - |
Net decrease in cash, cash equivalents, and restricted cash | ||||||||||
-94,155 | 47,056 | -48,746 | 65,115 | -45,199 | 53,442 | 7,022 | -11,267 | 22,187 | -42,985 | 34,717 |
Supplemental disclosure of cash flow information | ||||||||||
Cash paid for interest | ||||||||||
4,131 | 4,660 | 4,821 | - | - | - | - | - | - | - | - |
Noncash financing activity | ||||||||||
Subscription receivable | ||||||||||
- | -2,109 | 2,109 | - | 0 | - | - | - | - | - | - |
Public Offering [Member] | ||||||||||
Net proceeds common stock | ||||||||||
- | 69,987 | - | - | - | - | - | - | - | - | - |
At-the-market Offering [Member] | ||||||||||
Net proceeds common stock | ||||||||||
- | 29,653 | 5,026 | - | - | - | - | - | - | - | - |