| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | ||
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-46,971 | -37,545 | -25,567 | -9,518 | -2,811 | ||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
494 | 645 | 336 | 94 | 51 | ||
Amortization of intangible assets | ||||||
666 | 665 | 665 | 665 | 666 | ||
Loss on disposal of fixed assets | ||||||
- | -28 | - | - | - | ||
Stock-based compensation | ||||||
11,287 | 12,338 | 10,926 | 870 | 402 | ||
Net premium amortization and discount on available-for-sale securities | ||||||
521 | 140 | -26 | -4 | - | ||
Landlord incentive for tenant improvements | ||||||
- | - | 2,119 | - | - | ||
Change in deferred income taxes | ||||||
- | - | - | - | -1,657 | ||
Changes in operating assets and liabilities: | ||||||
Prepaid expenses and other current assets | ||||||
226 | 367 | 144 | 415 | 12 | ||
Right-of-use assets | ||||||
-68 | - | - | - | - | ||
Other long-term assets | ||||||
393 | - | 101 | - | - | ||
Deferred offering costs | ||||||
- | - | - | - | 347 | ||
Accounts payable | ||||||
646 | 490 | 517 | 3 | 125 | ||
Accrued expenses | ||||||
841 | 387 | 245 | 246 | 305 | ||
Lease liabilities | ||||||
-76 | - | - | - | - | ||
Other current and non-current liabilities | ||||||
- | -397 | -109 | - | - | ||
Deferred grant revenue | ||||||
- | - | - | - | -39 | ||
Net cash used in operating activities | ||||||
-34,185 | -23,896 | -11,087 | -8,051 | -3,317 | ||
Cash flows from investing activities: | ||||||
Purchases of property and equipment | ||||||
608 | 276 | 2,551 | 64 | 86 | ||
Purchases of investments | ||||||
77,993 | 40,297 | 43,595 | 19,067 | - | ||
Maturities of investments | ||||||
68,500 | 41,815 | 23,148 | 4,750 | - | ||
Sales of investments | ||||||
- | 24,875 | - | - | - | ||
Net cash provided by (used) in investing activities | ||||||
-10,101 | 26,117 | -22,998 | -14,381 | -86 | ||
Cash flows from financing activities: | ||||||
Proceeds from exercises of stock options and warrants | ||||||
272 | 498 | 539 | - | - | ||
Proceeds from issuance of common stock from private placements, net of issuance costs of $199 | ||||||
- | - | 34,843 | - | - | ||
Proceeds from issuance of common stock from initial public offering, net of issuance costs | ||||||
- | - | - | 20,915 | - | ||
Proceeds from issuance of common stock under employee stock purchase plan | ||||||
423 | 327 | - | - | - | ||
Proceeds from issuance of common stock from rights offering, net of issuance costs of $213 | ||||||
- | 44,786 | - | - | - | ||
Tax payments related to shares withheld for vested restricted stock units | ||||||
613 | 115 | - | - | - | ||
Net cash provided by financing activities | ||||||
82 | 45,496 | 35,382 | 20,915 | - | ||
Net increase (decrease) in cash | ||||||
-44,204 | 47,717 | 1,297 | - | - | ||
Net increase (decrease) in cash | ||||||
- | - | - | -1,517 | -3,403 | ||
Supplemental disclosure of noncash investing and financing activities: | ||||||
Reclassification of deferred offering costs to additional paid-in capital upon initial public offering | ||||||
- | - | - | 627 | - | ||
Equipment purchases included in accounts payable and accrued expenses | ||||||
279 | 33 | 38 | 18 | 104 | ||