| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Operating activities | ||||||||
Net loss | ||||||||
-77,677 | -155,645 | -153,237 | -160,108 | -80,612 | -7,150 | -40,996 | -41,411 | -29,670 |
Adjustments to reconcile net loss to cash used in operating activities: | ||||||||
Depreciation and amortization | ||||||||
1,564 | 3,216 | 3,067 | 2,427 | 806 | 743 | 660 | 468 | 391 |
Share-based compensation | ||||||||
23,585 | 26,062 | 26,764 | 24,929 | - | - | - | - | - |
Restructuring share-based compensation | ||||||||
0 | 948 | 0 | 0 | - | - | - | - | - |
Share-based compensation | ||||||||
- | - | - | - | 10,414 | 5,597 | 3,128 | 6,098 | 2,972 |
Excess tax benefit from share-based award exercises | ||||||||
- | - | - | - | - | 242 | 0 | 0 | - |
Deferred income taxes | ||||||||
-1,248 | -1,589 | -2,200 | -3,248 | -963 | -990 | -538 | 0 | 0 |
Interest expense under build-to-suit lease transaction | ||||||||
0 | 3,696 | 3,688 | 863 | 0 | 0 | - | - | - |
Amortization of right-of-use assets | ||||||||
5,256 | 0 | 0 | - | - | - | - | - | - |
Gain from early lease retirement | ||||||||
0 | 0 | 2,096 | 0 | 0 | - | - | - | - |
(Gain) loss on disposal of fixed asset | ||||||||
0 | -584 | 5 | 0 | -20 | 19 | 29 | 0 | 0 |
Loss on sublease | ||||||||
- | - | - | - | -261 | 0 | 0 | - | - |
Changes in operating assets and liabilities: | ||||||||
Accounts receivable | ||||||||
- | - | - | -331 | -1,220 | 1,729 | 0 | 0 | - |
Receivable from related party | ||||||||
- | - | - | - | -30 | -28 | -165 | 223 | 146 |
Prepaid and other assets | ||||||||
-807 | -9,377 | 7,311 | -3,363 | 937 | 2,352 | 721 | 467 | 0 |
Deferred revenue | ||||||||
0 | 110,242 | 0 | 0 | - | - | - | - | - |
Accounts payable, accruals and other liabilities | ||||||||
-78 | -25,628 | 147 | 15,193 | 11,161 | 5,431 | 6,233 | -6,537 | 6,756 |
Restructuring liability | ||||||||
-461 | 461 | 0 | 0 | - | - | - | - | - |
Operating lease liabilities | ||||||||
4,717 | 0 | 0 | - | - | - | - | - | - |
Net cash used in operating activities | ||||||||
-52,969 | -28,276 | -131,183 | -116,250 | -58,600 | -683 | -32,098 | -42,072 | -19,697 |
Investing activities | ||||||||
Purchases of property and equipment | ||||||||
555 | 1,768 | 3,626 | 16,644 | 1,382 | 526 | 564 | 1,301 | 595 |
Proceeds from disposal of fixed assets | ||||||||
8 | 39 | 105 | 0 | 0 | 27 | 29 | 0 | 0 |
Net cash used in investing activities | ||||||||
-547 | -1,729 | -3,521 | -16,644 | -1,382 | -499 | -535 | -1,301 | -595 |
Financing activities | ||||||||
Proceeds from issuance of ordinary shares in public offering, net | ||||||||
0 | 0 | 150,323 | 128,777 | 131,341 | 117,348 | 84,534 | 0 | 0 |
Proceeds from subscription of ordinary shares | ||||||||
0 | 39,758 | 0 | 0 | - | - | - | 26,000 | 0 |
Proceeds from funding provided by Elan | ||||||||
- | - | - | - | - | - | - | 145,233 | 20,292 |
Repayment of funding provided by Elan | ||||||||
- | - | - | - | - | - | - | 3,000 | 0 |
Post separation adjustments to the funding provided by Elan | ||||||||
- | - | - | - | - | - | 84 | 0 | 0 |
Proceeds from issuance of ordinary shares upon exercise of stock options | ||||||||
228 | 4,686 | 17,838 | 10,516 | 5,648 | 494 | 0 | 0 | - |
Reduction of build-to-suit lease obligation | ||||||||
0 | 4,400 | 2,760 | 169 | 0 | 0 | - | - | - |
Excess tax benefit from share-based award exercises | ||||||||
- | - | - | - | - | 242 | 0 | 0 | - |
Proceeds from tenant improvement allowance under build-to-suit lease | ||||||||
- | - | - | -14,163 | 0 | 0 | - | - | - |
Net cash provided by financing activities | ||||||||
228 | 40,044 | 165,401 | 153,287 | 136,989 | 118,084 | 84,450 | 168,233 | 20,292 |
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||||
-53,288 | 10,039 | 30,697 | 20,393 | 77,007 | - | - | - | - |
Supplemental disclosures of cash flow information | ||||||||
Cash paid for income taxes, net | ||||||||
1,580 | -995 | 294 | - | - | - | - | - | - |
Cash paid for income taxes, net of refunds | ||||||||
- | - | - | 575 | 442 | 1,588 | 796 | 0 | 0 |
Supplemental disclosures of non-cash investing and financing activities | ||||||||
Acquisition of property and equipment included in accounts payable and accrued liabilities | ||||||||
5 | 90 | 175 | 575 | 185 | 0 | 26 | 0 | 0 |
Right-of-use assets recorded upon adoption of ASC 842 | ||||||||
28,530 | 0 | 0 | - | - | - | - | - | - |
Reduction of build-to-suit lease obligation upon adoption of ASC 842 | ||||||||
51,546 | 0 | 0 | - | - | - | - | - | - |
Reduction of amounts capitalized under build-to-suit lease upon adoption of ASC 842 | ||||||||
46,760 | 0 | 0 | - | - | - | - | - | - |
Reduction of capitalized interest under build-to-suit lease upon adoption of ASC 842 | ||||||||
1,099 | 0 | 0 | - | - | - | - | - | - |
Net increase in cash, cash equivalents and restricted cash | ||||||||
-53,288 | 10,039 | 30,697 | 20,393 | 77,007 | 116,902 | - | - | - |
Net increase in cash and cash equivalents | ||||||||
- | - | - | - | - | - | 51,817 | 124,860 | 0 |
Receivable from option exercises | ||||||||
- | - | - | - | - | 6 | 0 | 0 | - |
Stock option shortfall | ||||||||
- | - | - | 258 | 0 | 0 | - | - | - |
Amounts capitalized under build-to-suit lease transaction | ||||||||
- | - | - | 36,805 | 0 | 0 | - | - | - |
Interest capitalized during construction period for build-to-suit lease transaction | ||||||||
- | - | - | 1,179 | 0 | 0 | - | - | - |
Offering costs included in accounts payable and accrued liabilities | ||||||||
- | - | - | - | 18 | 0 | 82 | 0 | 0 |