| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Collaboration revenue | ||||||||
814 | 955 | 27,519 | 1,055 | 1,607 | 50,320 | 0 | 0 | - |
Revenuerelated party | ||||||||
- | - | - | - | - | 534 | 676 | 2,658 | 507 |
Total revenue | ||||||||
814 | 955 | 27,519 | 1,055 | 1,607 | 50,854 | 676 | 2,658 | - |
Operating expenses: | ||||||||
Research and development | ||||||||
50,836 | 101,183 | 134,547 | 119,534 | 58,439 | 38,452 | 26,052 | 34,139 | 24,172 |
General and administrative | ||||||||
35,736 | 42,482 | 48,226 | 41,056 | 23,105 | 19,051 | 15,051 | 9,929 | 5,579 |
Restructuring credits | ||||||||
-61 | 16,145 | 0 | 0 | - | - | - | - | - |
Total operating expenses | ||||||||
86,511 | 159,810 | 182,773 | 160,590 | 81,544 | 57,503 | 41,103 | 44,068 | 29,751 |
Loss from operations | ||||||||
-85,697 | -158,855 | -155,254 | -159,535 | -79,937 | -6,649 | -40,427 | -41,410 | -29,244 |
Other income (expense): | ||||||||
Interest income | ||||||||
8,203 | 2,692 | -142 | 556 | 196 | 79 | - | - | - |
Interest income | ||||||||
- | - | - | - | - | - | 71 | 5 | 0 |
Other expense, net | ||||||||
196 | 48 | -2,207 | 15 | -170 | 231 | -225 | 0 | 0 |
Total other income, net | ||||||||
8,399 | 2,740 | -2,349 | 571 | 26 | 310 | -154 | 5 | 0 |
Loss before income taxes | ||||||||
-77,298 | -156,115 | -157,603 | -158,964 | -79,911 | -6,339 | -40,581 | -41,405 | -29,244 |
Income Tax Expense (Benefit) | ||||||||
379 | -470 | -4,366 | 1,144 | 701 | 811 | 415 | 6 | 426 |
Net Income (Loss) Attributable to Parent | ||||||||
-77,677 | -155,645 | -153,237 | -160,108 | -80,612 | -7,150 | -40,996 | -41,411 | -29,670 |
Basic and diluted net loss per share (in dollars per share) | ||||||||
-1.95 | -3.93 | -4.07 | -4.66 | -2.66 | -0.29 | -2.20 | -2.84 | -2.05 |
Weighted Average Number of Shares Outstanding, Basic and Diluted | ||||||||
39,882 | 39,559 | 37,654 | 34,351 | 30,326 | 24,672 | 18,615 | 14,593 | 14,497 |