| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 |
|---|---|---|---|---|---|---|---|---|
Revenues: | ||||||||
Grant revenue | ||||||||
- | - | - | - | - | - | - | 5,167 | 6,451 |
Revenue | ||||||||
306,980 | 264,734 | 194,392 | 82,705 | 36,766 | 25,245 | 34,696 | 33,946 | 105,412 |
Cost of Goods and Service, Excluding Amortization Of Intangible Assets | ||||||||
12,135 | 12,670 | 4,577 | 0 | 0 | - | - | - | - |
Operating expenses: | ||||||||
Amortization of acquired intangible assets | ||||||||
27,700 | 22,900 | 15,400 | 0 | 0 | - | - | - | - |
Research and development | ||||||||
257,452 | 171,984 | 117,456 | 117,633 | 121,816 | 79,838 | 54,875 | 46,139 | 58,677 |
Selling, general and administrative | ||||||||
202,541 | 153,548 | 121,271 | 97,130 | 82,080 | 44,820 | 25,219 | 14,615 | 16,153 |
Change in the fair value of deferred and contingent consideration | ||||||||
-48,360 | -19,340 | 0 | 0 | - | - | - | - | - |
Total operating expenses | ||||||||
548,138 | 380,419 | 258,684 | 214,763 | 203,896 | 124,658 | 80,094 | 60,754 | 74,830 |
Loss from operations | ||||||||
-241,158 | -115,685 | -64,292 | -132,058 | -167,130 | -99,413 | -45,398 | -26,808 | 30,581 |
Interest expense, net | ||||||||
-12,491 | -12,554 | -12,094 | -8,276 | -2,367 | 1,180 | -6,084 | -1,210 | -2,444 |
Loss on extinguishment of debt | ||||||||
- | - | - | - | - | - | -130 | - | - |
Other expense, net | ||||||||
13,723 | 129 | -1,279 | -1,207 | -465 | -213 | 38 | 1,783 | 461 |
Loss before income tax expense | ||||||||
-239,926 | -128,110 | -77,665 | -141,541 | -169,962 | -98,446 | -51,574 | -26,235 | 28,598 |
Income tax expense | ||||||||
11,650 | -29 | 1,335 | 569 | 485 | -4,693 | - | - | -2,305 |
Net Income (Loss) Attributable to Parent | ||||||||
-251,576 | -128,081 | -79,000 | -142,110 | -170,447 | - | -51,574 | -26,235 | 30,904 |
Deemed dividend | ||||||||
- | - | - | - | - | - | 18,249 | - | - |
Gain on exchange of convertible preferred stock in connection with recapitalization | ||||||||
- | - | - | - | - | - | 3,391 | 159,954 | - |
Less beneficial conversion charge | ||||||||
- | - | - | - | - | - | - | 378 | - |
Net loss attributable to common stockholders | ||||||||
- | - | - | - | - | -93,753 | -66,432 | 133,341 | 30,904 |
Basic net income (loss) per common share | ||||||||
- | - | - | - | - | - | - | 219.76 | 23.95 |
Diluted net income (loss) per common share | ||||||||
- | - | - | - | - | - | - | 42.50 | 4.55 |
Weighted Average Number of Shares Outstanding, Diluted [Abstract] | ||||||||
Weighted Average Number of Shares Outstanding, Basic and Diluted | ||||||||
58,863 | 46,576 | 39,183 | 34,044 | 33,626 | 31,565 | 12,829 | - | - |
Basic (in shares) | ||||||||
- | - | - | - | - | - | - | 3 | 1 |
Diluted (in shares) | ||||||||
- | - | - | - | - | - | - | 17 | 5 |
Earnings Per Share [Abstract] | ||||||||
Earnings Per Share, Basic and Diluted | ||||||||
-4.27 | -2.75 | -2.02 | -4.17 | -5.07 | -2.97 | -5.18 | - | - |
Product [Member] | ||||||||
Revenue | ||||||||
291,306 | 263,005 | 174,066 | 81,447 | 33,696 | 717 | - | - | - |
Collaboration and grant revenue | ||||||||
Revenue | ||||||||
15,674 | 1,729 | 20,326 | 1,258 | 3,070 | 24,528 | 34,696 | 28,779 | 98,960 |