| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | ||
|---|---|---|---|---|---|---|
CASH FLOWS FROM OPERATING ACTIVITIES | ||||||
Net loss | ||||||
-77,187 | -38,924 | -36,957 | -37,177 | -14,858 | ||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Stock-based compensation | ||||||
8,353 | 6,919 | 4,241 | 2,130 | 99 | ||
Operating lease right-of-use asset amortization | ||||||
1,792 | - | - | - | - | ||
Depreciation and amortization | ||||||
703 | 527 | 406 | 317 | 247 | ||
Amortization of debt issuance costs and accretion of debt discount | ||||||
29 | - | - | - | - | ||
Gain (loss) on disposal of property and equipment | ||||||
-8 | - | 62 | -34 | - | ||
Accretion of discount on marketable securities, net of premium amortization | ||||||
594 | -206 | -687 | -117 | 8 | ||
Change in deferred tax asset | ||||||
-775 | -658 | - | - | - | ||
Change in fair value associated with redeemable convertible preferred stock tranche liability | ||||||
- | - | - | 4,194 | 626 | ||
Change in fair value of redeemable convertible preferred stock warrant liability | ||||||
- | - | - | 525 | -543 | ||
Changes in operating assets and liabilities: | ||||||
Research and development tax incentive receivable | ||||||
-1,411 | 236 | -1,070 | 1,588 | 192 | ||
Receivable from collaboration partner - related party | ||||||
2,168 | 2,771 | 1,816 | - | - | ||
Prepaid expenses and other assets | ||||||
2,820 | -1,117 | 333 | 1,804 | 1,532 | ||
Accounts payable | ||||||
-3,000 | 4,430 | 91 | - | - | ||
Accounts payable | ||||||
- | - | - | -115 | 898 | ||
Payable to collaboration partner - related party | ||||||
201 | 1,061 | - | - | - | ||
Accrued expenses and other payables | ||||||
1,098 | 1,911 | 4,793 | 3,395 | 878 | ||
Deferred revenue - related party | ||||||
33,307 | -23,529 | 31,752 | - | - | ||
Operating lease liability | ||||||
1,885 | - | - | - | - | ||
Net cash used in operating activities | ||||||
-41,527 | -49,947 | 3,872 | -29,972 | -14,385 | ||
CASH FLOWS FROM INVESTING ACTIVITIES | ||||||
Purchase of marketable securities | ||||||
166,936 | 71,060 | 39,546 | - | - | ||
Purchase of available-for-sale securities | ||||||
- | - | - | 73,169 | 7,865 | ||
Proceeds from maturities of marketable securities | ||||||
114,193 | 73,759 | 56,035 | 14,188 | - | ||
Purchases of property and equipment | ||||||
967 | 486 | 666 | 347 | 399 | ||
Net cash provided by investing activities | ||||||
-53,710 | 2,213 | 15,823 | -59,328 | -8,264 | ||
CASH FLOWS FROM FINANCING ACTIVITIES | ||||||
Proceeds from at-the-market offering, net of issuance costs | ||||||
34,492 | 1,508 | - | - | - | ||
Proceeds from issuance of long-term debt, net of issuance costs | ||||||
9,765 | - | - | - | - | ||
Proceeds from issuance of common stock upon exercise of stock options and purchases under employee stock purchase plan | ||||||
1,779 | 934 | 1,007 | 151 | 57 | ||
Proceeds from issuance of common stock and warrants in private placement, net of issuance costs | ||||||
- | 21,673 | 64,547 | 83,648 | - | ||
Proceeds from issuance of redeemable convertible preferred stock, net of issuance costs | ||||||
- | - | - | 22,508 | 17,362 | ||
Net cash provided by financing activities | ||||||
46,036 | 24,115 | 65,554 | 106,307 | 17,419 | ||
Effect of exchange rate changes on cash, cash equivalents and restricted cash | ||||||
-26 | -177 | 146 | 22 | -39 | ||
Net increase (decrease) in cash, cash equivalents and restricted cash | ||||||
-49,227 | -23,796 | 85,395 | 17,029 | -5,269 | ||
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION: | ||||||
Cash paid for interest | ||||||
70 | - | - | - | - | ||
Effect of exchange rate changes on cash and cash equivalents | ||||||
-26 | -177 | 146 | 22 | -39 | ||
Net (decrease) increase in cash and cash equivalents | ||||||
-49,227 | -23,796 | 85,395 | 17,029 | -5,269 | ||
SUPPLEMENTAL DISCLOSURES OF NON-CASH FINANCING AND INVESTING INFORMATION: | ||||||
Purchases of property and equipment in accounts payable and accrued liabilities | ||||||
100 | 24 | - | 21 | - | ||
Deferred offering costs in accounts payable and accrued liabilities | ||||||
80 | - | 66 | - | - | ||
Fair value of common stock retired in exchange for issuance of common stock warrant | ||||||
- | 6,670 | - | - | - | ||
Acquisition of new equipment upon trade-in for existing equipment | ||||||
- | - | 185 | - | - | ||
Conversion of redeemable convertible preferred stock to common stock at closing of initial public offering | ||||||
- | - | - | 66,904 | - | ||
Settlement of fair value of redeemable convertible preferred stock liability | ||||||
- | - | - | 5,837 | - | ||
Reclassification of preferred stock warrant liability to equity | ||||||
- | - | - | 1,005 | - | ||
Accretion of redeemable convertible preferred stock | ||||||
- | - | - | 558 | 75 | ||
Tranche liability in connection with the Series C redeemable convertible preferred stock financing | ||||||
- | - | - | - | 1,017 | ||