| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | ||
|---|---|---|---|---|---|---|
Cash flows from operating activities: | ||||||
Net loss | ||||||
-59,125 | -61,832 | -59,432 | - | - | ||
Net loss | ||||||
- | - | - | -37,232 | -25,040 | ||
Adjustments to reconcile net loss to cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
1,414 | 1,778 | 1,402 | 306 | 272 | ||
Premium on short-term investments | ||||||
- | - | - | 184 | - | ||
Accretion of short-term investments | ||||||
958 | 438 | -178 | -77 | - | ||
Non-cash rent expense | ||||||
- | - | - | -181 | -63 | ||
Non-cash interest expense | ||||||
- | - | - | - | 599 | ||
Stock-based compensation expense | ||||||
3,352 | 3,526 | 2,965 | 1,805 | 472 | ||
Stock issued for consulting services | ||||||
242 | 889 | 767 | 359 | - | ||
Change in fair value of derivative liability | ||||||
- | -22 | -66 | 89 | -63 | ||
Loss on disposal of property and equipment | ||||||
-24 | -41 | - | - | - | ||
Change in fair value of preferred stock warrant liability | ||||||
- | - | - | -82 | -10 | ||
Gain on disposal of property and equipment | ||||||
- | - | - | 13 | - | ||
Changes in operating assets and liabilities: | ||||||
Accounts receivable | ||||||
- | - | -668 | -250 | -506 | ||
Prepaids and other current assets | ||||||
-1,077 | 1,104 | -2,682 | 3,871 | -190 | ||
Other assets | ||||||
- | -33 | -35 | -76 | -182 | ||
Accounts payable | ||||||
406 | -204 | 67 | -289 | 361 | ||
Accrued expenses | ||||||
1,402 | -242 | 1,481 | 2,350 | 498 | ||
Deferred revenue | ||||||
- | - | -1,848 | - | - | ||
Deferred revenue | ||||||
- | - | - | -5,385 | 2,681 | ||
Operating lease liabilities | ||||||
-1,056 | -1,269 | -1,294 | - | - | ||
Net cash used in operating activities | ||||||
-53,222 | -58,844 | -52,395 | - | - | ||
Cash flows from investing activities: | ||||||
Net cash used in operating activities | ||||||
- | - | - | -41,925 | -19,415 | ||
Purchases of short-term investments | ||||||
88,508 | 111,240 | 61,220 | 69,812 | - | ||
Proceeds received from maturities of short-term investments | ||||||
134,582 | 66,850 | 83,221 | 3,000 | - | ||
Purchases of property and equipment | ||||||
9 | 415 | 118 | 229 | 263 | ||
Net cash provided by investing activities | ||||||
46,065 | -44,805 | 21,883 | - | - | ||
Cash flows from financing activities: | ||||||
Proceeds from issuance of common stock | ||||||
- | - | - | 46,500 | - | ||
Proceeds from issuance of common stock | ||||||
3,504 | 21,703 | - | 70,265 | - | ||
Proceeds received from sale of property and equipment | ||||||
- | - | - | 13 | - | ||
Net cash provided by investing activities | ||||||
- | - | - | -67,028 | -263 | ||
Proceeds from issuance of convertible preferred stock, net of issuance costs | ||||||
- | - | - | - | 21,090 | ||
Proceeds from exercise of stock options | ||||||
3 | 21 | 31 | 268 | 95 | ||
Proceeds from issuance of common stock pursuant to employee stock purchase plan | ||||||
78 | 55 | - | - | - | ||
Proceeds from issuance of convertible promissory notes | ||||||
- | - | - | - | 5,000 | ||
Deferred offering costs | ||||||
230 | 431 | 35 | 3,311 | 1,456 | ||
Net cash provided by financing activities | ||||||
3,355 | 101,613 | 43,279 | - | - | ||
Net increase in cash, cash equivalents and restricted cash | ||||||
-3,802 | -2,036 | 12,767 | - | - | ||
Net cash provided by financing activities | ||||||
- | - | - | 113,722 | 24,729 | ||
Net increase in cash and cash equivalents | ||||||
- | - | - | 4,769 | 5,051 | ||
Supplemental disclosure of non-cash investing and financing activities: | ||||||
Conversion of convertible promissory notes and accrued interest into Series B convertible preferred stock | ||||||
- | - | - | - | 15,798 | ||
Conversion of convertible preferred stock into common stock | ||||||
- | - | - | 112,292 | - | ||
Issuance of common stock to settle accrued Series A preferred stock dividends | ||||||
- | - | - | 3 | - | ||
Issuance of common stock for partial payment of accrued bonus | ||||||
- | - | - | 62 | - | ||
Conversion of preferred stock warrants to common stock warrants | ||||||
- | - | - | 28 | - | ||
Deferred offering costs included in accounts payable and accrued expenses | ||||||
- | - | - | - | 1,288 | ||
At-the-market Common Stock Offering Program Sales Agreement [Member] | ||||||
Proceeds from issuance of common stock | ||||||
- | 80,265 | 43,240 | - | - | ||
Employee Stock Purchase Plan [Member] | ||||||
Proceeds from issuance of common stock | ||||||
- | - | 43 | - | - | ||
Accounts Payable [Member] | ||||||
Capital expenditures incurred but not yet paid | ||||||
24 | 230 | 321 | - | - | ||
Addition of Operating Lease Right-Of-Use Asset [Member] | ||||||
Capital expenditures incurred but not yet paid | ||||||
- | 14,962 | - | - | - | ||