| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | |
|---|---|---|---|---|---|---|
Cash flows from operating activities | ||||||
Net loss | ||||||
-124,201 | -83,304 | -79,260 | -73,374 | -82,083 | -49,777 | |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Depreciation and amortization | ||||||
6,669 | 12,415 | 7,543 | 6,089 | 6,324 | 2,580 | |
Share-based compensation expense | ||||||
17,533 | 10,708 | 10,280 | 6,214 | 11,617 | 8,396 | |
Change in fair value of derivative financial instruments | ||||||
2,530 | -4,054 | 5,194 | -1,865 | 8,508 | 23 | |
Unrealized foreign exchange gains | ||||||
-891 | 5,502 | -4,222 | 755 | 526 | 4,797 | |
Change in deferred tax expense | ||||||
- | 231 | 209 | 1,145 | -1,179 | -535 | |
Change in lease incentives | ||||||
- | -330 | 2,215 | 649 | -577 | 6,518 | |
Changes in operating assets and liabilities: | ||||||
Accounts receivable and accrued income, prepaid expenses and other current assets | ||||||
4,769 | -1,578 | -9,715 | 5,917 | 1,680 | 1,195 | |
Inventories | ||||||
- | - | - | -480 | 260 | -882 | |
Accounts payable | ||||||
1,652 | 1,065 | -1,670 | 344 | -774 | -321 | |
Accrued expenses, other liabilities and operating leases | ||||||
6,010 | -382 | -1,640 | 499 | 4,929 | 1,796 | |
Deferred revenue | ||||||
-4,999 | -8,462 | -21,078 | -5,698 | 63,169 | -421 | |
Net cash used in operating activities | ||||||
-98,684 | -76,037 | -64,270 | -72,189 | 7,468 | -36,851 | |
Cash flows from investing activities | ||||||
Purchases of intangible assets | ||||||
996 | 1,861 | 1,122 | 1,884 | 415 | 299 | |
Purchases of property, plant and equipment | ||||||
5,651 | 2,384 | 4,461 | 15,288 | 7,607 | 22,195 | |
Acquisition of business, net of cash acquired | ||||||
- | - | - | - | - | 1,448 | |
Net cash used in investing activities | ||||||
-6,647 | -4,245 | -5,583 | -17,172 | -8,022 | -23,942 | |
Cash flows from financing activities | ||||||
Proceeds from issuance of shares related to employee stock option and purchase plans | ||||||
5,603 | 4,825 | 4,044 | 2,593 | 2,865 | 596 | |
Proceeds from exercises of convertible loan warrants | ||||||
- | - | 1,322 | - | - | - | |
Proceeds from public offering of shares, net of issuance costs | ||||||
242,718 | 138,400 | 85,290 | - | 82,519 | 84,462 | |
Proceeds from loan increment | ||||||
- | 14,775 | - | - | - | 9,542 | |
Contingent consideration payment | ||||||
- | - | 582 | - | - | - | |
Proceeds from exercise of warrants | ||||||
500 | - | - | - | - | - | |
Proceeds from issuance of shares to collaboration partner | ||||||
- | - | - | - | 75,493 | - | |
Repayment of capital lease obligations | ||||||
- | - | - | 148 | 186 | 207 | |
Net cash generated from financing activities | ||||||
248,821 | 157,961 | 90,074 | 2,445 | 160,691 | 94,393 | |
Currency effect on cash, cash equivalents and restricted cash | ||||||
-106 | -2,187 | 7,306 | -1,629 | -3,198 | -1,689 | |
Net increase in cash, cash equivalents and restricted cash | ||||||
143,384 | 75,491 | 27,527 | -88,545 | 156,939 | 31,911 | |
Supplemental cash flow disclosures: | ||||||
Cash paid for interest | ||||||
-3,117 | 2,141 | 1,624 | 2,345 | 2,082 | 1,626 | |
Non-cash increases (decreases) in accounts payables related to purchases of intangible assets and property, plant and equipment | ||||||
313 | -48 | -1,557 | 1,174 | -792 | 411 | |