| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 | Dec'16 | Sep'16 | Jun'16 | Mar'16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Total revenues | ||||||||||||||||
6,249 | 7,281 | 6,264 | 8,366 | 8,942 | 11,284 | 12,260 | 11,372 | 13,264 | 13,107 | 19,654 | 24,615 | 24,124 | 25,098 | 0 | 0 | 0 |
Operating expenses: | ||||||||||||||||
Research and development expenses | ||||||||||||||||
100,213 | 94,737 | 86,962 | 83,949 | 78,288 | 74,809 | 74,301 | 73,863 | 72,236 | 72,172 | 73,942 | 70,443 | 72,798 | 72,510 | 0 | 0 | 0 |
Selling, general and administrative expenses | ||||||||||||||||
34,549 | 33,544 | 32,076 | 29,045 | 27,071 | 25,305 | 25,378 | 25,064 | 24,578 | 24,635 | 23,106 | 22,635 | 25,059 | 25,999 | 0 | 0 | 0 |
Total operating expenses | ||||||||||||||||
134,762 | 128,281 | 119,038 | 112,994 | 105,359 | 100,114 | 99,679 | 98,927 | 96,814 | 96,807 | 97,048 | 93,078 | 97,857 | 98,509 | 0 | 0 | 0 |
Other income | ||||||||||||||||
2,432 | 1,888 | 1,741 | 1,845 | 1,844 | 2,146 | 2,172 | 16,028 | 15,729 | 15,430 | 15,204 | 1,127 | 1,336 | 1,465 | 0 | 0 | 0 |
Other expense | ||||||||||||||||
2,018 | 2,028 | 1,334 | 1,482 | 1,564 | 1,548 | 1,513 | 3,663 | 0 | - | 0 | 0 | - | - | - | - | - |
Loss from operations | ||||||||||||||||
-128,099 | -121,140 | -112,367 | -104,265 | -96,137 | -88,232 | -86,671 | -72,722 | -71,227 | -71,343 | -65,091 | -69,976 | -72,397 | -71,946 | 0 | 0 | 0 |
Interest income | ||||||||||||||||
3,927 | 3,547 | 2,982 | 3,063 | 2,918 | 2,729 | 1,869 | 930 | 359 | 117 | 52 | 56 | 59 | 70 | 0 | 0 | 0 |
Interest expense | ||||||||||||||||
3,828 | 3,810 | 3,518 | 3,073 | 2,701 | 2,160 | 2,145 | 2,207 | 2,144 | 2,232 | 2,070 | 2,000 | 2,047 | 2,172 | 0 | 0 | 0 |
Foreign currency (losses) / gains, net | ||||||||||||||||
2,060 | -268 | 8,557 | 2,971 | 6,478 | 4,382 | 1,167 | 31 | -3,295 | -3,566 | 953 | 1,138 | 3,129 | 1,034 | 0 | 0 | 0 |
Other non-operating (losses) / gains, net | ||||||||||||||||
1,512 | -2,530 | -323 | -1,828 | -2,522 | 208 | -2,794 | -3,062 | -1,761 | -2,435 | 113 | 167 | 497 | 785 | 0 | 0 | 0 |
Loss before income tax expense | ||||||||||||||||
- | - | -104,669 | -103,132 | - | -83,073 | -88,574 | -77,030 | -78,068 | -79,459 | -66,043 | -70,615 | -70,759 | -72,229 | 0 | 0 | 0 |
Income tax (expense) / benefit | ||||||||||||||||
- | - | - | - | - | 231 | -41 | 0 | 0 | - | 0 | - | - | 1,145 | 0 | 0 | 0 |
Net loss | ||||||||||||||||
-124,428 | -124,201 | -104,663 | -103,094 | -92,287 | -83,304 | -88,890 | -77,100 | -77,777 | -79,260 | -66,509 | -71,536 | -71,347 | -73,374 | 0 | 0 | 0 |
Other comprehensive (loss) / income: | ||||||||||||||||
Foreign currency translation adjustments net of tax impact of nil for the year ended December 31, 2019 (2018: $(0.2) million and 2017: $0.2 million) | ||||||||||||||||
-7,175 | 570 | -3,394 | 1,971 | -2,614 | -5,261 | -2,345 | -1,524 | 2,256 | 2,757 | -2,361 | 418 | -4,087 | 271 | 0 | 0 | 0 |
Total comprehensive loss | ||||||||||||||||
-131,603 | -123,631 | -108,057 | -101,123 | -94,901 | -88,565 | -91,235 | -78,624 | -75,521 | -76,503 | -68,870 | -71,118 | -75,434 | -73,103 | 0 | 0 | 0 |
Basic and diluted net loss per ordinary share | ||||||||||||||||
-0.63 | -2,278.68 | -0.58 | -830.00 | -0.74 | -1,179.41 | -0.59 | -570.00 | -590.00 | -2,937.97 | -0.40 | -0.83 | -0.80 | -0.58 | -0.61 | -0.84 | -0.90 |
Weighted average shares used in computing basic and diluted net loss per ordinary share | ||||||||||||||||
44,279 | 43,757 | 40,738 | 37,824 | 37,676 | 37,396 | 37,247 | 36,205 | 31,710 | 31,300 | 25,632 | 25,560 | 25,443 | 25,229 | 25,142 | 25,077 | 24,696 |
License revenues | ||||||||||||||||
Total revenues | ||||||||||||||||
- | - | - | - | - | - | - | - | - | 8 | 246 | 492 | 968 | 975 | 0 | 0 | 0 |
License revenues from related party | ||||||||||||||||
Total revenues | ||||||||||||||||
4,400 | 5,000 | 3,934 | 5,634 | 5,649 | 7,500 | 8,114 | 6,738 | 5,602 | 4,100 | 4,023 | 3,892 | 3,911 | 3,940 | 0 | 0 | 0 |
Collaboration revenues | ||||||||||||||||
Total revenues | ||||||||||||||||
- | - | - | - | - | - | - | - | - | 4,638 | 6,968 | 8,818 | 7,318 | 7,164 | 0 | 0 | 0 |
Collaboration revenues from related party | ||||||||||||||||
Total revenues | ||||||||||||||||
1,778 | 2,300 | 2,365 | 2,791 | 3,352 | 3,800 | 4,067 | 4,573 | 4,769 | 4,300 | 8,417 | 11,413 | 11,927 | 13,019 | 0 | 0 | 0 |