| Dec'19 | Dec'18 | Dec'17 | Dec'16 | |||
|---|---|---|---|---|---|---|
Cash flow from operating activities | ||||||
Net loss | ||||||
-84,710 | -49,594 | -53,082 | -17,970 | |||
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||
Stock-based compensation expense | ||||||
8,981 | 3,874 | 495 | 90 | |||
Depreciation and amortization | ||||||
3,578 | 3,664 | 2,612 | 1,314 | |||
Share of loss from equity method investee | ||||||
-1,202 | -886 | -416 | 0 | |||
Gain on deemed sale from equity method investee | ||||||
0 | 1,229 | 0 | 0 | |||
Amortization of premiums on investments | ||||||
2,638 | 1,752 | 0 | 0 | |||
Other non-operating income | ||||||
0 | 177 | 98 | 0 | |||
Changes in operating assets and liabilities: | ||||||
Receivable from collaboration partners | ||||||
132 | 0 | - | - | |||
Amounts owed by a related party | ||||||
-83 | 58 | -380 | 0 | |||
Prepaid expenses and other current assets | ||||||
1,982 | 1,180 | 751 | 602 | |||
Other long-term assets | ||||||
588 | 80 | 6 | 200 | |||
Accounts payable | ||||||
1,726 | -69 | -267 | 3,569 | |||
Accrued liabilities | ||||||
3,499 | 3,497 | 1,582 | 808 | |||
Other current liabilities | ||||||
57 | 43 | -136 | 647 | |||
Deferred revenue | ||||||
-2,000 | -353 | 23,587 | 0 | |||
Deferred rent | ||||||
-538 | -468 | 209 | -600 | |||
Net cash used in operating activities | ||||||
-73,462 | -42,996 | -25,059 | -12,944 | |||
Cash flow from investing activities | ||||||
Purchases of short-term and long-term investments | ||||||
247,755 | 261,552 | 96,830 | 33,762 | |||
Proceeds from maturities of short-term and long-term investments | ||||||
308,892 | 151,855 | 53,273 | 0 | |||
Purchases of property and equipment | ||||||
1,925 | 3,743 | 5,514 | 4,099 | |||
Investment in related party | ||||||
- | - | 0 | 1,000 | |||
Net cash provided by investing activities | ||||||
59,212 | -113,440 | -49,071 | -38,861 | |||
Cash flow from financing activities | ||||||
Proceeds from initial public offering, net of issuance costs | ||||||
0 | 125,111 | 0 | 0 | |||
Proceeds from issuance of common stock | ||||||
1,217 | 4,098 | - | - | |||
Repurchase of common stock issued under early exercised options | ||||||
94 | 0 | - | - | |||
Proceeds from issuance of preferred stock, net of issuance costs | ||||||
- | - | 106,877 | 69,817 | |||
Proceeds from issuance of common stock upon exercise of stock options, net of repurchases | ||||||
- | - | 892 | 283 | |||
Deferred initial public offering costs | ||||||
- | - | 373 | 0 | |||
Payment of preferred stock issuance costs | ||||||
0 | 135 | 0 | 0 | |||
Net cash provided by (used in) financing activities | ||||||
1,123 | 129,074 | 107,396 | 70,100 | |||
Net increase (decrease) in cash and cash equivalents | ||||||
-13,127 | -27,362 | 33,266 | 18,295 | |||
Non-cash investing and financing activities: | ||||||
Unpaid financing cost included in accounts payable and accrued liabilities | ||||||
- | - | 1,058 | 0 | |||
Unpaid portion of property and equipment purchases included in accounts payable and accrued liabilities | ||||||
12 | 136 | 338 | 618 | |||
Vesting of early exercised stock options and restricted stock | ||||||
1,029 | 1,276 | 235 | 63 | |||