| Mar'20 | Dec'19 | Sep'19 | Jun'19 | Mar'19 | Dec'18 | Sep'18 | Jun'18 | Mar'18 | Dec'17 | Sep'17 | Jun'17 | Mar'17 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flow from operating activities | ||||||||||||
Net loss | ||||||||||||
-94,793 | -84,710 | -80,407 | -68,866 | -54,310 | -49,594 | -50,509 | -62,820 | -58,836 | -53,082 | 0 | 0 | 0 |
Adjustments to reconcile net loss to net cash used in operating activities: | ||||||||||||
Stock-based compensation expense | ||||||||||||
10,769 | 8,981 | 7,598 | 5,906 | 4,892 | 3,874 | 2,975 | 2,064 | 1,079 | 495 | 0 | 0 | 0 |
Depreciation and amortization | ||||||||||||
3,467 | 3,578 | 3,669 | 3,757 | 3,789 | 3,664 | 3,483 | 3,241 | 2,954 | 2,612 | 0 | 0 | 0 |
Share of loss from equity method investee | ||||||||||||
-1,253 | -1,202 | -1,525 | -1,353 | -1,091 | -886 | -719 | -652 | -572 | -416 | 0 | 0 | 0 |
Gain on deemed sale from equity method investee | ||||||||||||
482 | 0 | 0 | 0 | 0 | - | - | - | - | - | - | - | - |
Amortization of premiums on investments | ||||||||||||
2,139 | 2,638 | 2,948 | 3,332 | 2,499 | 1,752 | 0 | 0 | 0 | - | - | - | - |
Other non-operating income | ||||||||||||
- | - | - | - | - | 177 | 199 | 222 | 127 | 98 | 0 | 0 | 0 |
Changes in operating assets and liabilities: | ||||||||||||
Receivable from collaboration partners | ||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Amounts owed by a related party | ||||||||||||
0 | -83 | -114 | -131 | -54 | 58 | 79 | 172 | 54 | -380 | 0 | 0 | 0 |
Prepaid expenses and other current assets | ||||||||||||
4,927 | 1,982 | 1,894 | 1,723 | 1,246 | 1,180 | 651 | 794 | 1,348 | 751 | 0 | 0 | 0 |
Other long-term assets | ||||||||||||
649 | 588 | 59 | 115 | 110 | 80 | 0 | 0 | 0 | - | - | - | - |
Accounts payable | ||||||||||||
-99 | 1,726 | 866 | -1,982 | -280 | -69 | 1,010 | 2,690 | 2,119 | -267 | 0 | 0 | 0 |
Accrued liabilities | ||||||||||||
2,541 | 3,499 | 2,995 | 11,214 | 4,693 | 3,497 | 5,112 | 2,573 | 2,461 | 1,582 | 0 | 0 | 0 |
Other current liabilities | ||||||||||||
43 | 57 | 52 | 52 | 48 | 43 | -131 | -136 | -137 | -136 | 0 | 0 | 0 |
Deferred revenue | ||||||||||||
-2,000 | -2,000 | -1,812 | -1,353 | -853 | -353 | 0 | 0 | 0 | - | - | - | - |
Deferred rent | ||||||||||||
-540 | -538 | -521 | -506 | -510 | -468 | 343 | 301 | 277 | 209 | 0 | 0 | 0 |
Net cash used in operating activities | ||||||||||||
-87,900 | -73,462 | -71,098 | -55,464 | -46,588 | -42,996 | -20,302 | -32,771 | -28,709 | -25,059 | 0 | 0 | 0 |
Cash flow from investing activities | ||||||||||||
Purchases of short-term and long-term investments | ||||||||||||
184,233 | 247,755 | 219,730 | 294,718 | 292,875 | 261,552 | 281,179 | 156,061 | 116,560 | 96,830 | 0 | 0 | 0 |
Proceeds from maturities of short-term and long-term investments | ||||||||||||
270,728 | 308,892 | 295,544 | 257,408 | 213,522 | 151,855 | 126,941 | 97,603 | 71,920 | 53,273 | 0 | 0 | 0 |
Purchases of property and equipment | ||||||||||||
1,506 | 1,925 | 1,987 | 2,564 | 3,317 | 3,743 | 3,779 | 3,491 | 4,429 | 5,514 | 0 | 0 | 0 |
Net cash provided by investing activities | ||||||||||||
84,989 | 59,212 | 73,827 | -39,874 | -82,670 | -113,440 | -158,017 | -61,949 | -49,069 | -49,071 | 0 | 0 | 0 |
Cash flow from financing activities | ||||||||||||
Proceeds from initial public offering, net of issuance costs | ||||||||||||
- | - | - | - | - | 125,111 | 0 | 0 | 0 | - | - | - | - |
Proceeds from issuance of common stock | ||||||||||||
0 | - | - | - | 0 | - | - | - | - | - | - | - | - |
Repurchase of unvested shares of stock | ||||||||||||
0 | - | 0 | 0 | 0 | - | 0 | 0 | 0 | - | - | - | - |
Proceeds from issuance of common stock upon exercise of stock options, net of repurchases | ||||||||||||
- | - | - | - | - | - | 3,422 | 3,615 | 4,167 | 892 | 0 | 0 | 0 |
Payment of preferred stock issuance costs | ||||||||||||
- | - | - | - | - | 135 | 0 | 0 | 0 | - | - | - | - |
Net cash provided by (used in) financing activities | ||||||||||||
1,738 | 1,123 | 1,374 | 1,408 | -359 | 129,074 | 234,902 | 235,098 | 236,795 | 107,396 | 0 | 0 | 0 |
Net increase (decrease) in cash and cash equivalents | ||||||||||||
-1,173 | -13,127 | 4,103 | -93,930 | -129,617 | -27,362 | 56,583 | 140,378 | 159,017 | 33,266 | 0 | 0 | 0 |
Non-cash investing and financing activities: | ||||||||||||
Unpaid financing cost included in accounts payable and accrued liabilities | ||||||||||||
- | - | - | - | - | - | - | - | 0 | - | - | - | - |
Unpaid portion of property and equipment purchases included in accounts payable and accrued liabilities | ||||||||||||
-292 | 12 | 66 | -823 | -179 | 136 | 418 | 850 | -67 | 338 | 0 | 0 | 0 |
Vesting of early exercised stock options and restricted stock | ||||||||||||
976 | 1,029 | 1,078 | 1,162 | 1,271 | 1,276 | 1,077 | 796 | 491 | 235 | 0 | 0 | 0 |