| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 |
|---|---|---|---|---|---|---|---|---|---|
CASH FLOWS USED IN OPERATING ACTIVITIES: | |||||||||
Net loss | |||||||||
-132,993 | -221,337 | -254,237 | -182,804 | -101,526 | -62,479 | -60,690 | -69,128 | -42,476 | -14,630 |
Adjustments to reconcile net loss to net cash used in operating activities: | |||||||||
Depreciation and amortization | |||||||||
2,308 | 2,867 | 1,951 | 586 | 176 | 77 | 27 | 44 | 40 | 70 |
Gain on fixed asset disposal | |||||||||
- | - | - | - | - | - | - | - | - | 100 |
Amortization of discount on marketable securities, net | |||||||||
394 | 390 | 264 | -791 | -1,714 | -429 | -27 | -101 | -21 | -303 |
Research and development expense settled in stock | |||||||||
- | - | - | - | - | 2,717 | 13,118 | 15,067 | 10,296 | - |
Change in fair value of other current assets, warrant liability and other liability | |||||||||
- | - | - | - | - | 505 | -9,087 | 2,069 | 264 | - |
Amortization of debt discount and debt issuance costs | |||||||||
15,785 | 13,800 | 4,816 | 0 | 183 | 295 | 387 | 449 | 165 | - |
Impairment loss on operating lease right of use assets | |||||||||
339 | - | - | - | - | - | - | - | - | - |
Stock-based compensation | |||||||||
23,615 | 28,701 | 35,003 | 26,058 | 14,734 | 7,070 | 1,508 | 1,795 | 304 | 134 |
Loss on disposals of property and equipment | |||||||||
-201 | 0 | 0 | - | - | - | - | - | - | - |
Loss on retirement of note payable | |||||||||
- | - | - | - | 1,572 | 57 | - | - | - | - |
Milestone payment settled with stock | |||||||||
- | - | - | - | - | - | - | - | 1,410 | - |
Changes in operating assets and liabilities: | |||||||||
Inventory | |||||||||
-887 | 1,844 | 4,366 | 0 | 0 | - | - | - | - | - |
Accounts receivable, net | |||||||||
6,531 | 12,317 | 4,441 | 0 | 0 | - | - | - | - | - |
Prepaid expenses | |||||||||
- | - | - | - | - | 1,639 | -1,721 | -4,623 | 6,463 | 133 |
Prepaid expenses | |||||||||
-1,711 | 8,667 | 3,689 | 342 | 1,157 | - | - | - | - | - |
Other current assets | |||||||||
-356 | -989 | 1,362 | -4,996 | 3,757 | - | - | - | - | - |
Operating lease right of use assets | |||||||||
2,034 | - | - | - | - | - | - | - | - | - |
Other long-term assets | |||||||||
-30 | -255 | 248 | 291 | 108 | 105 | - | -35 | -25 | 27 |
Accounts payable | |||||||||
1,804 | 311 | -2,213 | -100 | 3,936 | 1,991 | -250 | 237 | -301 | -94 |
Accrued expenses and other current liabilities | |||||||||
10,827 | -7,000 | 22,563 | 11,349 | -2,870 | 2,737 | 8,222 | 1,550 | 819 | 1,491 |
Lease liability, operating leases | |||||||||
2,298 | - | - | - | - | - | - | - | - | - |
Other non-current liabilities | |||||||||
-95 | -94 | -190 | 0 | 0 | - | - | - | - | - |
Net cash used in operating activities | |||||||||
-82,414 | -204,726 | -206,677 | -139,757 | -87,103 | -48,345 | -45,017 | -43,158 | -35,896 | -12,986 |
CASH FLOWS PROVIDED BY INVESTING ACTIVITIES: | |||||||||
Purchases of property and equipment | |||||||||
0 | 185 | 2,341 | 2,936 | 1,231 | 857 | 2 | 40 | 176 | 14 |
Collaborative Arrangement, Milestone Payments | |||||||||
0 | 0 | 8,712 | 0 | 0 | - | - | - | - | - |
Purchases of marketable securities | |||||||||
119,502 | 499 | 429,296 | 260,547 | 579,088 | 97,678 | 17,070 | 18,989 | 32,479 | 24,120 |
Proceeds from sale of equipment | |||||||||
- | - | - | - | - | - | - | - | - | 149 |
Sales and maturities of marketable securities | |||||||||
206,779 | 135,000 | 191,363 | 499,603 | 340,497 | 20,470 | 21,043 | 46,464 | 8,855 | 39,655 |
Net cash provided by (used in) investing activities | |||||||||
87,277 | 134,316 | -248,986 | 236,120 | -239,822 | -78,065 | 3,971 | 27,435 | -23,800 | 15,670 |
CASH FLOWS PROVIDED BY FINANCING ACTIVITIES: | |||||||||
Proceeds from exercise of stock options and warrant exercises | |||||||||
3,869 | 9,106 | 17,478 | 2,573 | 2,337 | 170 | 13 | 279 | 204 | - |
Net proceeds from the issuance of preferred stock, net | |||||||||
- | - | - | - | - | 27,368 | 42,870 | - | 62,116 | - |
Proceeds from issuance of convertible notes | |||||||||
0 | 0 | 305,000 | 0 | 0 | 24,555 | - | 12,500 | 12,500 | - |
Proceeds from issuance of common stock, net | |||||||||
- | - | - | - | 482,250 | 103,804 | - | - | - | 2 |
Discount on note payable | |||||||||
- | - | - | - | - | - | - | - | 366 | - |
Deferred financing costs | |||||||||
0 | 0 | 9,360 | 0 | 0 | 116 | - | 31 | 56 | - |
Payments on note payable | |||||||||
- | - | - | - | 25,000 | 13,156 | 8,187 | 3,500 | 156 | - |
Fee for early prepayment of note payable | |||||||||
- | - | - | - | 1,502 | 0 | - | - | - | - |
Proceeds from issuance of shares under employee stock purchase plan | |||||||||
1,840 | 2,566 | 2,550 | 0 | 0 | - | - | - | - | - |
Net cash provided by financing activities | |||||||||
5,709 | 11,672 | 315,668 | 2,573 | 458,085 | 142,625 | 34,696 | 9,248 | 74,242 | 2 |
NET INCREASE (DECREASE) IN CASH, CASH EQUIVALENTS, AND RESTRICTED CASH | |||||||||
10,572 | -58,738 | -139,995 | 98,936 | 131,160 | 16,215 | -6,350 | -6,475 | 14,546 | 2,686 |
SUPPLEMENTAL DISCLOSURES: | |||||||||
Cash paid for interest | |||||||||
9,150 | 9,582 | 0 | 0 | 1,490 | 1,971 | 1,796 | 1,801 | 358 | - |
Accretion of preferred stock issuance costs | |||||||||
- | - | - | - | - | - | - | - | - | 173 |
NON-CASH FINANCING ACTIVITIES: | |||||||||
Accretion of dividends on preferred stock | |||||||||
- | - | - | - | - | 9,000 | 17,471 | -13,992 | -10,933 | 10,651 |
Reclassification of preferred stock to common stock | |||||||||
- | - | - | - | - | 298,063 | - | - | - | - |
Accretion of preferred stock investor rights/obligations | |||||||||
- | - | - | - | - | - | - | - | - | 1,318 |
Property and equipment purchases in accrued expense | |||||||||
0 | 309 | 352 | 675 | 0 | 0 | - | - | - | - |
Right of use assets obtained in exchange for operating lease liability | |||||||||
9,077 | - | - | - | - | - | - | - | - | - |
Fair value of preferred stock issued in the recapitalization | |||||||||
- | - | - | - | - | - | - | - | 85,879 | - |
Fair value of series A-6 convertible preferred stock issued as settlement of liability | |||||||||
- | - | - | - | - | 10,109 | 23,168 | - | - | - |
Fair value of warrants issued | |||||||||
- | - | - | - | - | 1,552 | 1,356 | 379 | 463 | - |