| Dec'19 | Dec'18 | Dec'17 | Dec'16 | Dec'15 | Dec'14 | Dec'13 | Dec'12 | Dec'11 | Dec'10 | Dec'09 | Dec'08 |
|---|---|---|---|---|---|---|---|---|---|---|---|
Cash flows from operating activities: | |||||||||||
Net Income (Loss) Attributable to Parent | |||||||||||
2,115,800 | 2,444,400 | 1,198,500 | 895,500 | 636,056 | 338,126 | 413,738 | 750,269 | -221,760 | -104,468 | -67,830 | -79,129 |
Adjustments to reconcile net income to net cash provided by operating activities: | |||||||||||
Depreciation and amortization | |||||||||||
210,300 | 148,200 | 145,500 | 104,700 | 74,909 | 52,686 | 41,204 | 36,940 | 31,082 | 19,687 | 14,247 | 11,287 |
Non-cash compensation expense | |||||||||||
464,300 | 427,400 | 507,300 | 559,900 | 459,049 | 321,750 | 215,377 | 94,157 | 56,094 | 39,897 | 31,259 | 32,523 |
Other non-cash items, net | |||||||||||
29,300 | -12,100 | -63,500 | -45,100 | -52,562 | -77,571 | -46,751 | -34,049 | -6,714 | -4,037 | -2,238 | - |
Non-cash interest expense | |||||||||||
- | - | - | - | - | - | - | 22,925 | 5,101 | 43 | - | - |
Loss on Extinguishment of Debt | |||||||||||
- | - | - | - | - | - | 0 | 0 | - | - | - | -938 |
Net realized loss (gain) on marketable securities | |||||||||||
- | - | - | - | - | - | - | - | - | - | - | -1,310 |
Deferred taxes | |||||||||||
130,600 | 140,000 | -318,800 | 360,100 | 121,623 | 53,276 | -62,195 | 340,156 | 0 | 0 | - | - |
Changes in assets and liabilities: | |||||||||||
Increase in Sanofi, trade, and other accounts receivable | |||||||||||
473,100 | 268,900 | 362,700 | 143,800 | 491,421 | 34,927 | 245,472 | 588,398 | 21,118 | 17,518 | 30,494 | 16,892 |
Increase in inventories | |||||||||||
335,500 | 387,900 | 314,200 | 149,800 | 111,825 | 56,947 | 47,956 | 28,932 | 14,094 | - | - | - |
Decrease in prepaid expenses and other assets | |||||||||||
130,400 | 55,700 | 113,300 | -36,100 | 79,476 | 45,327 | -7,571 | 25,371 | -6,612 | 8,212 | 4,436 | 6,560 |
Increase in deferred revenue | |||||||||||
294,000 | -194,500 | -113,100 | 244,300 | 608,892 | -8,403 | -41,496 | -41,077 | -40,329 | 158,151 | -27,497 | -26,834 |
(Decrease) increase in accounts payable, accrued expenses, and other liabilities | |||||||||||
444,500 | 210,000 | -23,200 | 254,000 | 303,657 | 161,182 | 136,684 | 10,979 | 50,016 | 7,605 | 12,577 | -5,729 |
Total adjustments | |||||||||||
314,200 | -249,300 | 108,600 | 590,400 | 694,724 | 414,309 | 174,858 | -824,884 | 80,078 | 203,690 | -2,106 | -9,957 |
Net cash provided by operating activities | |||||||||||
2,430,000 | 2,195,100 | 1,307,100 | 1,485,900 | 1,330,780 | 752,435 | 588,596 | -74,615 | -141,682 | 99,222 | -69,936 | -89,086 |
Cash flows from investing activities: | |||||||||||
Purchases of marketable and other securities | |||||||||||
3,202,400 | 1,845,500 | 1,277,200 | 809,400 | 557,105 | 564,188 | 577,278 | 470,945 | 240,391 | 605,124 | 199,997 | 581,139 |
Sales or maturities of marketable securities | |||||||||||
1,604,200 | 775,600 | 544,600 | 274,500 | 327,437 | 476,417 | 378,146 | 439,209 | 426,356 | 273,723 | 295,117 | 646,861 |
Purchase of restricted cash and marketable securities | |||||||||||
- | - | - | - | - | - | - | - | 277 | 5,941 | -50 | 0 |
Capital expenditures | |||||||||||
429,600 | 383,100 | 272,600 | 511,900 | 677,933 | 333,006 | 156,323 | 49,337 | 57,217 | 99,689 | 97,318 | 34,857 |
Other | |||||||||||
0 | 10,000 | 0 | 0 | - | - | - | - | - | - | - | - |
Increase in restricted cash | |||||||||||
- | - | - | - | - | - | - | - | - | - | - | 50 |
Net cash used in investing activities | |||||||||||
-2,027,800 | -1,463,000 | -1,005,200 | -1,046,800 | -907,601 | -420,777 | -355,455 | -81,073 | 128,471 | -437,031 | -2,148 | 30,815 |
Cash flows from financing activities: | |||||||||||
Proceeds in connection with capital and facility lease obligations | |||||||||||
- | - | - | 5,100 | 27,373 | -1,095 | -2,024 | - | - | - | - | 0 |
Payments in connection with capital and facility lease obligations | |||||||||||
- | 0 | 19,900 | 32,800 | 1,353 | - | - | 2,203 | 1,667 | 1,028 | 0 | 0 |
Proceeds in connection with finance lease liabilities | |||||||||||
- | 0 | 57,000 | - | - | - | - | - | - | 47,544 | 23,640 | - |
Payments in connection with facility lease obligation | |||||||||||
- | - | - | - | - | - | - | - | - | - | 875 | 0 |
Repayments of Convertible Debt | |||||||||||
- | - | - | 12,900 | 166,467 | 220,639 | 0 | 0 | - | - | - | - |
Payments for Repurchase of Warrants | |||||||||||
- | - | - | 643,400 | 573,487 | 294,552 | 0 | 0 | - | - | - | - |
Repurchases or repayment of notes payable | |||||||||||
- | - | - | - | - | - | - | - | - | - | - | -200,807 |
Proceeds from issuance of Common Stock | |||||||||||
211,800 | 114,500 | 240,200 | 126,700 | 206,358 | 126,045 | 57,393 | 63,549 | 43,587 | 200,588 | 8,598 | 7,949 |
Payments in connection with Common Stock tendered for employee tax obligations | |||||||||||
188,000 | 187,200 | 301,700 | 143,200 | 160,537 | 267,584 | 195,087 | 163,300 | 25,078 | 3,798 | - | - |
Repurchases of Common Stock | |||||||||||
275,900 | 4,400 | 0 | 0 | - | - | - | - | - | - | - | - |
Excess Tax Benefit from Share-based compensation | |||||||||||
- | - | - | - | 405,317 | 439,278 | 211,909 | 4,308 | 0 | 0 | - | - |
Proceeds in connection with issuance of convertible notes, net of debt issuance costs | |||||||||||
- | - | - | - | - | - | - | - | 391,107 | 0 | 0 | - |
Proceeds in connection with issuance of warrants | |||||||||||
- | - | - | - | - | - | - | - | 93,800 | 0 | 0 | - |
Payment in connection with purchase of convertible note hedges | |||||||||||
- | - | - | - | - | - | - | - | 117,500 | 0 | 0 | - |
Net cash provided by financing activities | |||||||||||
-252,100 | -77,100 | -24,400 | -700,500 | -262,796 | -218,547 | 72,191 | -97,646 | 384,249 | 243,306 | 31,363 | -192,858 |
Net increase in cash, cash equivalents, and restricted cash | |||||||||||
150,100 | 655,000 | 277,500 | -261,400 | 160,383 | 113,111 | 305,332 | -253,334 | 371,038 | -94,503 | -40,721 | -251,129 |
Supplemental Cash Flow Information [Abstract] | |||||||||||
Cash paid for interest (net of amounts capitalized) | |||||||||||
25,000 | 22,300 | 18,700 | 5,500 | 10,582 | 20,348 | 23,197 | 21,946 | 14,725 | 12,737 | 2,525 | 9,348 |
Cash paid for income taxes | |||||||||||
342,300 | 205,600 | 754,800 | 481,400 | 276,092 | 59,847 | 1,057 | 0 | - | - | - | 3,079 |